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Doctor insights on: Serotonin Syndrome Long Term Effects

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What are the long term effects of serotonin syndrome (if it was undiagnosed)?

What are the long term effects of serotonin syndrome (if it was undiagnosed)?

Depends: some cases the symptoms are mild and hardly noticed (increased reflexes and mild hyper-vigilance) . Some acute cases require urgent intervention to avoid the consequences of a sustained elevated temperature (acidosis, renal failure due to muscle breakdown) Elevated blood pressure can cause problems. Sleep can be disrupted. Mania can be precipitated. See MD if you think you have this problem. ...Read more

Dr. Andrew Berry
176 doctors shared insights

Serotonin Syndrome (Definition)

Complex as can be grouped with neuroleptic malignant syndrome. Characterized by hyperthermia, muscle rigidity, altered mental status, usually associated with medicines that block or deplete dopamine, such as most anti-psychotics, and ssri antidepressants. May be precipitated by fever, infection, high environmental temperatures. Can be life ...Read more


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I had serotonin syndrome after being given zyvox while on 40 mg of Paxil (paroxetine) six years ago. What are long term effects? I still do not feel like myself.

I had serotonin syndrome after being given zyvox while on 40 mg of Paxil (paroxetine) six years ago.  What are long term effects?  I still do not feel like myself.

Well: I am not aware of any long term affects from seratonin syndrome. As a result, however, you probably got off all the meds that could help. Not feeling well may be related to undertreated anxiety but not due to brain damage from seratonin syndrome. Sleeping well? Panic attacks, sad? Low energy? It could be the same issues for which u were taking the meds 6 years ago. Good luc but care if not get. ...Read more

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Can you get serotonin syndrome from long term Zoloft (sertraline) use?

Can you get serotonin syndrome from long term Zoloft (sertraline) use?

Combo or high dose: Serotonin syndrome is too much serotonin in the brain. If you have tolerated zoloft (sertraline) for a long time, than your chances of developing the syndrome are low, unless your dose was increased or another med added. Other psychotropics, pain meds (e.g. Ultram), migraine meds (triptans), HIV meds, stimulants & hallucinogens w/ zoloft (sertraline) can raise the risk. Inform your doctor of all the meds you're taking. ...Read more

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Can serotonin syndrome (3 times) cause long term muscle weakness, tachycardia, twitching and cognitive impairment? Would it be permanent?

Can serotonin syndrome (3 times) cause long term muscle weakness, tachycardia, twitching and cognitive impairment? Would it be permanent?

See a doctor: you need to see a doctor serotonin syndrome patient should be under the care of a specialist with medication it will not be permanent should be controlled my medication stay with your physician and follow their instructions ...Read more

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How high would CK be with serotonin syndrome? How long would it stay elevated?

How high would CK be with serotonin syndrome? How long would it stay elevated?

NMS?: You might be thing of NMS which can occur with antipsychotic meds ...Read more

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Muscle damage from serotonin syndrome. Is it permanent? If not, how do the muscles repair themselves? How long would CK remain elevated?

Serotonin Syndrome: There should be complete recovery without any sequelae, unless it is treated late or there is organ damage. However - this is somewhat rare. Most symptoms resolve after the drug is completely washed out of the body. Hope that helps! ...Read more

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Should discontinuing my medication get rid of serotonin syndrome? Went to ER and they did nothing. How long will it take for me to recover?

Serotonin Syndrome: The major symptoms can sometimes dissipate as quickly as 24 hours. I have only seen a handful of patients with this condition. For most of them it took several days for them to solidly feel better. ...Read more

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How long should I wait to begin Prozac (fluoxetine) after taking a single non-repetitive dose of Trazodone to avoid elevated risk of serotonin syndrome?

How long should I wait to begin Prozac (fluoxetine) after taking a single non-repetitive dose of Trazodone to avoid elevated risk of serotonin syndrome?

Ask your doctor: According to your profile, you're pregnant so please check with your OB to make sure both meds are ok to take. Not sure what "non-repetitive" Trazodone dose means. Do you mean "as needed for" ? what you don't say. Good you're cautious about taking these meds especially if pregnant. Don't know doses so best to check also with your prescribing doctor if that person isn't your OB. Hope this helps. ...Read more

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Started 20mg Lexapro, (escitalopram) was on 40mg Prozac for about 8 months. I switched straight over. Since Prozac has long HL, is serotonin syndrome possible?

Started 20mg Lexapro, (escitalopram) was on 40mg Prozac for about 8 months. I switched straight over. Since Prozac has long HL, is serotonin syndrome possible?

Practically NO: Seratonin syndrome is real but extremely rare. Only about 2 per million will,experience it. Those that I have seen are on many agents that elevate serotonin, or interfere with its metabolism, allowing it to accumulate. St Joh's Wart is a particularly bad agent, causing this when taken along with SSRIs like you mentioned. So, while it is possible for you to get it, the odds are against this. ...Read more

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Can prolonged serotonin syndrome (4 1/2 months of savella (milnacipran) and tramadol taken together) cause damage to the central nervous system?

Serotonin Syndrome: It's possible, if a hypertensive crisis or spike in BP occurred . Micro vascular CNS infarcts may be a residual. It doesn't seem likely as it went on for months and would have been picked up by your md. Serotonin syndrome is a serious condition which makes people very sick. Symptoms are significantly debilitating. Milder forms would be very unlikely to leave sequelae. ...Read more

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Tapering effexor (venlafaxine) xr- dropped to 150mg from 225mg on saturday, and added 30mg duloxetine. Anxious, shaky hands, and nauseous. Is this withdrawal or serotonin syndrome? How long will this last?

Tapering effexor (venlafaxine) xr- dropped to 150mg from 225mg on saturday, and added 30mg duloxetine. Anxious, shaky hands, and nauseous. Is this withdrawal or serotonin syndrome? How long will this last?

Med interaction: Effexor (venlafaxine) + duloxetine interact to increase risk for serotonin syndrome. Call prescribing doctor for advice or go to urgent care for help if symptoms don't improve or get worse. See: http://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/basics/definition/CON-20028946 I hope this helps. ...Read more

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Given Lexapro (escitalopram) 5mg (only med), afraid of serotonin syndrome. Many symptoms of ss are the same as the listed side effects for lexapro (escitalopram). How do u tell?

Given Lexapro (escitalopram) 5mg (only med), afraid of serotonin syndrome. Many symptoms of ss are the same as the listed side effects for lexapro (escitalopram). How do u tell?

Temperature: You are conceptualizing it right although there is the issue of magnitude. Also, the incidence of serotonin syndrome being quite low. An important issue that occurs in serotonin syndrome is the disruption in thermoregulation resulting in very elevated body temperatures. This is not commonly seen as a side effect to lexapro (escitalopram). I would talk with your prescribing doctor about your concerns! ...Read more

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What are the most common symptoms of serotonin syndrome?

See link: Agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, sweating, diarrhea, muscle twitching, shivering, goose bumps. See link for more info: http://www.Mayoclinic.Com/health/serotonin-syndrome/ds00860/dsection=symptoms. ...Read more

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What doctors treat serotonin syndrome?

What doctors treat serotonin syndrome?

Serotonin syndrome: Overactivation due to excess serotonin. See diagram. Treatment is emergency intervention if severe, and discontinuing the medication if less severe. Some medications used are Muscle relaxants, serotonin blockers such as Periactin, (cyproheptadine hydrochloride) Oxygen & intravenous fluids. ...Read more

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Can you got serotonin syndrome from a ssri?

Yes, but uncommon: You can get serotonin syndrome. With flushing, fever, rapid heart rate, blood pressure elevation, etc from ssris, but it is very uncommon with these drugs in the normal doses that are given. It can occur however, if you are taking another drug that boosts serotonin along with the ssri, which is why its important to keep you doctor posted on all meds changed or added including over the counter. ...Read more

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Can i experience a stroke or serotonin syndrome?

Can i experience a stroke or serotonin syndrome?

RVCS: If the question is can stroke happen as a result of serotonin syndrome, then the answer is: rarely. Serotonin syndrome at times can cause stroke-like symptoms because of blood vessels in the brain temporarily narrowing. It is called reversible cerebral vasoconstriction syndrome. It can be a serious condition, though it often reverses itself. ...Read more

Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more