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Doctor insights on: Serotonin Syndrome Long Term Effects

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What are the long term effects of serotonin syndrome (if it was undiagnosed)?

What are the long term effects of serotonin syndrome (if it was undiagnosed)?

Depends: some cases the symptoms are mild and hardly noticed (increased reflexes and mild hyper-vigilance) . Some acute cases require urgent intervention to avoid the consequences of a sustained elevated temperature (acidosis, renal failure due to muscle breakdown) Elevated blood pressure can cause problems. Sleep can be disrupted. Mania can be precipitated. See MD if you think you have this problem. ...Read more

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Dr. Warren Strudwick
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Dr. Joan Gelin
128 doctors shared insights

Serotonin Syndrome (Definition)

Complex as can be grouped with neuroleptic malignant syndrome. Characterized by hyperthermia, muscle rigidity, altered mental status, usually associated with medicines that block or deplete dopamine, such as most anti-psychotics, and ssri antidepressants. May be precipitated by fever, infection, high environmental temperatures. Can be life ...Read more


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I had serotonin syndrome after being given zyvox while on 40 mg of Paxil six years ago. What are long term effects? I still do not feel like myself.

I had serotonin syndrome after being given zyvox while on 40 mg of Paxil six years ago.  What are long term effects?  I still do not feel like myself.

Well: I am not aware of any long term affects from seratonin syndrome. As a result, however, you probably got off all the meds that could help. Not feeling well may be related to undertreated anxiety but not due to brain damage from seratonin syndrome. Sleeping well? Panic attacks, sad? Low energy? It could be the same issues for which u were taking the meds 6 years ago. Good luc but care if not get. ...Read more

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Dr. Warren Strudwick
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Can you get serotonin syndrome from long term Zoloft use?

Combo or high dose: Serotonin syndrome is too much serotonin in the brain. If you have tolerated zoloft for a long time, than your chances of developing the syndrome are low, unless your dose was increased or another med added. Other psychotropics, pain meds (e.g. Ultram), migraine meds (triptans), HIV meds, stimulants & hallucinogens w/ zoloft can raise the risk. Inform your doctor of all the meds you're taking. ...Read more

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Can serotonin syndrome (3 times) cause long term muscle weakness, tachycardia, twitching and cognitive impairment? Would it be permanent?

Can serotonin syndrome (3 times) cause long term muscle weakness, tachycardia, twitching and cognitive impairment? Would it be permanent?

See a doctor: you need to see a doctor serotonin syndrome patient should be under the care of a specialist with medication it will not be permanent should be controlled my medication stay with your physician and follow their instructions ...Read more

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Dr. Warren Strudwick
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Muscle damage from serotonin syndrome. Is it permanent? If not, how do the muscles repair themselves? How long would CK remain elevated?

Serotonin Syndrome: There should be complete recovery without any sequelae, unless it is treated late or there is organ damage. However - this is somewhat rare. Most symptoms resolve after the drug is completely washed out of the body. Hope that helps! ...Read more

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Should discontinuing my medication get rid of serotonin syndrome? Went to ER and they did nothing. How long will it take for me to recover?

Serotonin Syndrome: The major symptoms can sometimes dissipate as quickly as 24 hours. I have only seen a handful of patients with this condition. For most of them it took several days for them to solidly feel better. ...Read more

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How long should I wait to begin Prozac after taking a single non-repetitive dose of Trazodone to avoid elevated risk of serotonin syndrome?

How long should I wait to begin Prozac after taking a single non-repetitive dose of Trazodone to avoid elevated risk of serotonin syndrome?

Ask your doctor: According to your profile, you're pregnant so please check with your OB to make sure both meds are ok to take. Not sure what "non-repetitive" Trazodone dose means. Do you mean "as needed for" ? what you don't say. Good you're cautious about taking these meds especially if pregnant. Don't know doses so best to check also with your prescribing doctor if that person isn't your OB. Hope this helps. ...Read more

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Can prolonged serotonin syndrome (4 1/2 months of savella and tramadol taken together) cause damage to the central nervous system?

Serotonin Syndrome: It's possible, if a hypertensive crisis or spike in BP occurred . Micro vascular CNS infarcts may be a residual. It doesn't seem likely as it went on for months and would have been picked up by your md. Serotonin syndrome is a serious condition which makes people very sick. Symptoms are significantly debilitating. Milder forms would be very unlikely to leave sequelae. ...Read more

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Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more


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Dr. Warren Strudwick
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