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Doctor insights on: Serotonin Reuptake Syndrome

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more


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What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

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How do "serotonin antagonist and reuptake inhibitors" ssris work?

How do "serotonin antagonist and reuptake inhibitors" ssris work?

Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more

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What about cymbalta (duloxetine) discontinuation syndrome?

What about cymbalta (duloxetine) discontinuation syndrome?

It can: Discontinuation syndrome is seen with Cymbalta (duloxetine) and needs to monitored. It can avoided by decreasing slowly before discontinuing. The usual symptoms include but not limited to are dizziness, confusion, yawning, anxiety and irritability. ...Read more

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Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et.Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

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What are alternatives to serotonin reuptake inhibitors (ssris)?

What are alternatives to serotonin reuptake inhibitors (ssris)?

Several: Although ssris have been by far the most popular class of antidepressants for many years, there are several other options that focus on different systems. Wellbutrin is thought to work through dopamine; remeron, cymbalta, effexor, (venlafaxine) & others, also affect norepinephrin; and deprenyl and others are MAO inhibitors. Each has pluses and minues and may work when ssris don't. ...Read more

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Can serotonin syndrome cause brain damage/dementia/heart damage? Took high dose ADHD meds and effexor (venlafaxine).

Can serotonin syndrome cause brain damage/dementia/heart damage? Took high dose ADHD meds and effexor (venlafaxine).

Unlikely: Serotonin Syndrome may cause fevers and seizures but unlikely dementia or heart failure. Speak with your doctor if you are concern of the dosage and quantity of your medications More info on serotonin syndrome: http://www.mayoclinic.org/diseases-conditions/serotonin-syndrome/basics/definition/con-20028946 ...Read more

Dr. Alan Ali Dr. Ali
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How is serotonin syndrome treated?

Dr. Alan Ali Dr. Ali
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How is serotonin syndrome treated?

Serotonin syndrome: Overactivation due to excess serotonin. See diagram. Treatment is emergency intervention if severe, and discontinuing the medication if less severe. Some medications used are Muscle relaxants, serotonin blockers such as Periactin, (cyproheptadine hydrochloride) Oxygen & intravenous fluids. ...Read more

Dr. Alan Ali Dr. Ali
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Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Dr. Alan Ali Dr. Ali
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Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Zoloft (sertraline): Yes it is. Dopamin reuptake inhibition increases as dose increase. ...Read more

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Can cymbalta (duloxetine) increases ADHD symptoms?

Can cymbalta (duloxetine) increases ADHD symptoms?

Can cause agitation: Medications like Cymbalta (duloxetine) can cause activation and agitation causing restlessness and possible poor concentration. This is not adhd per se, but if you are more agitated and activated on the cymbalta, (duloxetine) it may mimic 'hyperactivity'. Please consult your prescribing physician as this may be a side effect of the Cymbalta (duloxetine) requiring an adjustment or change in medication. ...Read more

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Do norepinephrine reuptake inhibitors suppress growth of brain?

Do norepinephrine reuptake inhibitors suppress growth of brain?

No: At this time, there is no evidence to suggest this. As one may imagine, few if any studies have been performed in humans to look for this. ...Read more

Dr. Alan Ali Dr. Ali
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How is serotonin syndrome treated?

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Serotonin syndrome: Overactivation due to excess serotonin. See diagram. Treatment is emergency intervention if severe, and discontinuing the medication if less severe. Some medications used are Muscle relaxants, serotonin blockers such as Periactin, (cyproheptadine hydrochloride) Oxygen & intravenous fluids. ...Read more