Top
20
Doctor insights on: Serotonin Norepinephrine Reuptake Inhibitor Antidepressant

Share
1

1
Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more


2

2
Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et.Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

See 1 more doctor answer
3

3
How do "serotonin antagonist and reuptake inhibitors" ssris work?

How do "serotonin antagonist and reuptake inhibitors" ssris work?

Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more

4

4
What are alternatives to serotonin reuptake inhibitors (ssris)?

What are alternatives to serotonin reuptake inhibitors (ssris)?

Several: Although ssris have been by far the most popular class of antidepressants for many years, there are several other options that focus on different systems. Wellbutrin is thought to work through dopamine; remeron, cymbalta, effexor, (venlafaxine) & others, also affect norepinephrin; and deprenyl and others are MAO inhibitors. Each has pluses and minues and may work when ssris don't. ...Read more

See 1 more doctor answer
6

6
Which ssri/ anxiety/depression med lowers libido?

Which ssri/ anxiety/depression med lowers libido?

All: Most all antidepressants can affect a person's normal sexual functioning at various different levels and in different ways. The antidepressants which affect serotonin can cause problems with the ability to have an orgasm. The one antidepressant which has the lowest risk for sexual side-effects is called buproprion or wellbutrin (bupropion). ...Read more

7

7
What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

8

8
What antidepressant medications selectively block neurotransmitters?

Most newer ones: Most of the newer antidepressant medications affect specific neurotransmitters. Each does it slightly differently, accounting for the different response rates amongst them. The SSRI's primarily increase serotonin, the SNRI's both serotonin and norepinephrine, and buproprion mostly norepinephrine alone, and Brintellix affects many of them in different ways and in different places in the brain. ...Read more

10

10
Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Zoloft (sertraline): Yes it is. Dopamin reuptake inhibition increases as dose increase. ...Read more

11

11
Do norepinephrine reuptake inhibitors suppress growth of brain?

Do norepinephrine reuptake inhibitors suppress growth of brain?

No: At this time, there is no evidence to suggest this. As one may imagine, few if any studies have been performed in humans to look for this. ...Read more

12

12
Is risperdal dopamine agonist?

Is risperdal dopamine agonist?

No: How Risperdal (also called risperidone) works isn't entirely clear. It does act on Dopamine receptors, but it's an antagonist. It's also a serotonin receptor antagonist. ...Read more

See 1 more doctor answer
13

13
Is wellbutrin (bupropion) a dopamine agonist drug?

Is wellbutrin (bupropion) a dopamine agonist drug?

Mostly: Wellbutrin (bupropion) interferes with reuptake of dopamine&norepinephrine(noradrenaline)in the central nervous system, thereby leaving these neurotransmitters to sit longer&stronger in the synapse between communicating brain cells, which enhances dopamine&adrenaline activity at the cellular level. That can treat depression, feed pleasure to help sex&bypass tobacco, improve adhd&cognition, lower weight, etc. ...Read more

See 2 more doctor answers
14

14
Is the antidepressant tofranil (imipramine) effective?

Is the antidepressant tofranil (imipramine) effective?

Yes: It is effective and sometimes works better than the new ones on the minus side it has anticholinergic side effects: dry mouth blurred vision constipation hot flashes etc. ...Read more

15

15
When should someone take selective serotonin re-uptake inhibitors?

Depression: These medications are usually a first line medication for depression although they have other uses. ...Read more

16

16
Is Wellbutrin (bupropion) an ssri?

Is Wellbutrin (bupropion) an ssri?

No.: Wellbutrin is an aminoketone class antidepressant. It works in the brain by increasing dopamine and norepinephrine. SSRIs increase the levels of serotonin in the brain and include drugs like citalopram, escitalopram, fluoxetine, paroxetine, and sertraline. ...Read more

See 1 more doctor answer
17

17
Can wellbutrin (bupropion) affect serotonin levels?

No: Preclinical and clinical data demonstrate that bupropion acts via dual inhibition of norepinephrine and Dopamine reuptake, which constitutes a novel mechanism of antidepressant action. As such, bupropion is associated with a unique clinical profile with efficacy comparable to that of other antidepressants. Devoid of clinically significant serotonergic effects... www.ncbi.nlm.nih.gov/pmc/articles/pm. ...Read more

18

18
Is buproprion a monoamine oxidase inhibitor (maoi) type of drug?

No: Bupropion (wellbutrin) inhibits re-uptake of norepinephrine and Dopamine into neurons (nerve and brain cells). It does not inhibit mao, so there are no dietary restrictions or common medication interactions, unlike the the maois. ...Read more

See 1 more doctor answer
Dr. Ravi Chand
756 doctors shared insights

Norepinephrine (Definition)

Norepinephrine is an inotrope which is a kind of heart ...Read more


Dr. Ravi Chand
76 doctors shared insights

Levophed (Definition)

Levophed is an inotrope which is a kind of heart ...Read more