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Doctor insights on: Sensory Receptor

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Does triavil block dopamine receptors in the central nervous system?

Does triavil block dopamine receptors in the central nervous system?

Yes: Triavil is an old medicine that is not often used anymore. It's a combination of Amitriptyline and perphenazine. The latter is a neuroleptic (antipsychotic) medication that mainly acts by blocking Dopamine receptors in the brain. ...Read more

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Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


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What are GABA antagonists that lead to gaba-a receptor up-regulation?

What are GABA antagonists that lead to gaba-a receptor up-regulation?

Not safe: GABA antagonists are not routinely prescribed for GABA A receptor upregulation. The main one flumazenil (clonazepam) is used for overdoses from benzodiazepines in an ER setting. It may cause withdrawal seizures. Your best bet is to detox and enter a drug tx program for alcohol or sedative-hypnotic dependence issues. ...Read more

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Is there a test to detect autoantibodies against peripheral glutamate receptors (glutamate receptors in peripheral tissues)...?

Is there a test to detect autoantibodies against peripheral glutamate receptors (glutamate receptors in peripheral tissues)...?

Possibly, not likely: There may be a possible tests to detect antibodies to the peripheral tissues, but it would likely require a biopsy. It would be very difficult to differentiate antibodies also because they would be in present in your entire body rather than just in one location. ...Read more

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Each peripheral nerve provides what innervation to peripheral structures.?

Each peripheral nerve provides what innervation to peripheral structures.?

Good question: I wish I could remember. When I have a question about that, I get out my old anatomy book from med school and look it up. The book is 1100 pages long. I refer to it frequently when I want to relearn what peripheral nerve innervates what structure. For laypeople I recommend Frank Netter's Atlas of Human Anatomy. It's available from Amazon. ...Read more

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Are NMDA receptors or ampa receptors found outside of the brain and spinal cord?

Are NMDA receptors or ampa receptors found outside of the brain and spinal cord?

Glutamate receptors: Glutamate is the major excitatory neurotransmitter in the cns, and could be expressed elsewhere in body, but the receptor description used above is designed to study brain pathways pre-dominantly, and has not be studied extensively othewise. Nmda antagonism is mechanism of several drugs, but to date, no successful ampa agonist. ...Read more

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Can working with NMDA receptor antagonists cause psychosis?

Can working with NMDA receptor antagonists cause psychosis?

Working with?: The nmda receptor agents are a new and exciting arae in the treatment of psychotic disorders. When added to current therapies it can help. But these effects must be monitored by your doctor and therapist and family (if available to give feedback). Laboratory and industrial exposure may cause untoward CNS activation in workers. Most labs have saftey standards for safe use of chemical process. ...Read more

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Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Yes. Great Question!: The Amino Acid glutamate plays a central role in nitrogen metabolism & participates in multiple biochemical pathways. Disease examples: autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Anti-nmda receptor encephalitis is a treatment-responsive inflammatory encephalopathic autoimmune disease associated with anti-nmda receptor antibodies. ...Read more

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Which pain-causing diseases/disorders cause malfunction in transient receptor potential cation channels of subclass a type (trpa1)? Autoantibodies?

Which pain-causing diseases/disorders cause malfunction in transient receptor potential cation channels of subclass a type (trpa1)?  Autoantibodies?

TRPA1 Gene Family: The best article i've read on this gene family is ===> http://www.Genecards.Org/cgi-bin/carddisp.Pl?Gene=trpa1. The clinical significance of mutations in this gene has been related to caffeine and nicotine sensitivity disorders, and rare environmentally-triggered pain disorders. The complete function of this gene family is not known. ...Read more

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Would a neurotrophic virus cause pain upon uptake into sensory nerves?

Would a neurotrophic virus cause pain upon uptake into sensory nerves?

Yes: Any virus that affects the nervous system may cause nerve pain due to inflammation that develops as a result of its action. ...Read more

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What could a nicotinic receptor antagonist do to the post-synaptic response to nerve stimulation?

What could a nicotinic receptor antagonist do to the post-synaptic response to nerve stimulation?

Good question: It depends on the agent. Your possibilities include permanent blockade, transitory blocking or nothing. The next neuron in series fires if there is spatial and / or temporal summation of EPSP's relative to inhibitory inputs. The rate of subsequent firing also depends on weather or not you are dealing with a neuron that is acing as a pacemaker (eg lateral geniculate nucleus) ...Read more

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Is nerve stimulation effected by taser?

Is nerve stimulation effected by taser?

You bet: Taser overloads the nerve-muscle connections causing total weakness and collapse if used properly, but occasionally can cause cardiovascular collapse in addition. ...Read more

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Does activation of Histamine 1 receptors cause peripheral dilation or constriction?

Does activation of Histamine 1 receptors cause peripheral dilation or constriction?

Vasodilation: Histamine causes increased blood flow and swelling by dilating the blood vessels. This results in redness and swelling noted during an allergic response. ...Read more

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Are the NMDA receptors and nr1 subunit in the cerebellum?

Are the NMDA receptors and nr1 subunit in the cerebellum?

You're confused: Neuronal receptors are proteins that float around in neurons' cell membranes. The nr1 subunit is a part of the nmda receptor. Nmda receptors make up only about 1% of cerebral neuronal receptors but they are widely distributed throughout the entire brain. They play a part in long-term potentiation, which is believed to be one of the mechanisms of learning and memory. ...Read more

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Since there's deep brain stimulation that stimulate neurons, is there deep brain "inhibition" that inhibits neurons?

Since there's deep brain stimulation that stimulate neurons, is there deep brain "inhibition" that inhibits neurons?

Yes: It is interesting that it is called " stimulation", in fact it inhibits the neuron depending upon the degree of stimulation applied. For example the involuntary movement of Parkinson's disease are controlled by "inhibition". Similarly " interstim" is the technique to stimulate to cause inhibition of bladder contractions to cure loss of urinaty control. The entire process is well understood. ...Read more

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What are NMDA receptors?

What are NMDA receptors?

See below: Please consult this site for information : http://www.ncbi.nlm.nih.gov/books/NBK5284/ ...Read more