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Doctor insights on: Selegiline Interactions

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Dr. Lawrence Kessler
31 doctors shared insights

Selegiline (Definition)

Selegiline is a dopamine affecting agent which is a kind of anti-Parkinson's drug ...Read more


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Does selegiline make me feel sleepy?

Does selegiline make me feel sleepy?

Possible but ...: Selegiline more often causes insomnia than sleepiness. But both are possible side effects. Talk with your doc! ...Read more

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Does pomegranate contain tyramine in it, since I take selegiline and must avoid tyramine?

Does pomegranate contain tyramine in it, since I take selegiline and must avoid tyramine?

? Migraine: If tyramine problem=migraine, here is a list of foods that are rich in tyramine to avoid triggering headaches: chocolate, yoghurt, all cheese except cottage cheese, smoked/pickled fish/meats (inc herring, caviar, bologna, salami, pepperoni), liver, avocados, bananas, figs, raisins+ red wine. Check out my plate recommendations for food ideas, alternatives. From a fellow migraineur since childhood:). ...Read more

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Is selegiline effective as azilect (rasagiline) for parkinsons?

Is selegiline effective as azilect (rasagiline) for parkinsons?

MAO-B inhibitors: Both selegiline (eldepryl) and Rasagiline (azilect) are mao-b inhibitors, with a couple important differences. Azilect (rasagiline) is much more specific for mao-b, meaning no risk of serotonergic crisis when used alongside ssri antidepressants (celexa, lexapro, etc). Azilect (rasagiline) is also the only neuroprotective drug for parkinson's. Take care! ...Read more

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How effective is Eldepryl (selegiline) for treating depression?

How effective is Eldepryl (selegiline) for treating depression?

Eldepryl (selegiline): Used as Transdermal Patch called EMSAM, it can be very effective for resistant depression, as long as strict diet restrictions are applied, similar to other MAO inhibitors. ...Read more

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Have any docs had positive results using selegiline for depression? I am currently taking 15-20mg qd and my depression is essentially resolved. Thanks

Outstanding!: Selegiline does work in selected patients. It is not the first choice or even the second or third. Thanks for the feedback. ...Read more

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If used concurrently could selegiline + clonidine have additive effect for ADHD?

If used concurrently could selegiline + clonidine have additive effect for ADHD?

Selegiline and: Clonidine have no known interactions so they are okay together. Clonidine may lower blood pressure while selegiline may interact with meds and foods with possible increase in blood pressure. Review interactions. Both have an effect in treatment of ADHD for some individuals and if they work for you then effects would be additive. Best regards for good health. ...Read more

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How does eldepryl (selegiline) manage symptoms of Parkinson's disease?

How does eldepryl (selegiline) manage symptoms of Parkinson's disease?

It boosts dopamine!!: Eldepryl is o/w called selegine or zelapar (oral-disintegrating form). It's a mao-i (mono amine oxidase inhibitor) which slows the breakdown of dopamine, the central chemical deficient in parkinson's. Thereby it boosts the natural Dopamine made by the brain or the synthetic Dopamine in sinemet. Thus, symptoms are more fully & consistently treated. Azilect (rasagiline) is a much better modern choice, however. ...Read more

Dr. Linda Callaghan
18 doctors shared insights

Eldepryl (Definition)

Eldepryl is a dopamine affecting agent which is a kind of anti-Parkinson's drug ...Read more