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Doctor insights on: Selegiline Interactions

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Dr. Dariush Saghafi
31 doctors shared insights

Selegiline (Definition)

Selegiline is a dopamine affecting agent which is a kind of anti-Parkinson's drug ...Read more


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Does selegiline make me feel sleepy?

Does selegiline make me feel sleepy?

Possible but ...: Selegiline more often causes insomnia than sleepiness. But both are possible side effects. Talk with your doc! ...Read more

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Does pomegranate contain tyramine in it, since I take selegiline and must avoid tyramine?

Does pomegranate contain tyramine in it, since I take selegiline and must avoid tyramine?

? Migraine: If tyramine problem=migraine, here is a list of foods that are rich in tyramine to avoid triggering headaches: chocolate, yoghurt, all cheese except cottage cheese, smoked/pickled fish/meats (inc herring, caviar, bologna, salami, pepperoni), liver, avocados, bananas, figs, raisins+ red wine. Check out my plate recommendations for food ideas, alternatives. From a fellow migraineur since childhood:). ...Read more

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Is selegiline effective as azilect (rasagiline) for parkinsons?

Is selegiline effective as azilect (rasagiline) for parkinsons?

MAO-B inhibitors: Both selegiline (eldepryl) and Rasagiline (azilect) are mao-b inhibitors, with a couple important differences. Azilect (rasagiline) is much more specific for mao-b, meaning no risk of serotonergic crisis when used alongside ssri antidepressants (celexa, lexapro, etc). Azilect (rasagiline) is also the only neuroprotective drug for parkinson's. Take care! ...Read more

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How effective is Eldepryl (selegiline) for treating depression?

How effective is Eldepryl (selegiline) for treating depression?

Eldepryl (selegiline): Used as Transdermal Patch called EMSAM, it can be very effective for resistant depression, as long as strict diet restrictions are applied, similar to other MAO inhibitors. ...Read more

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Have any docs had positive results using selegiline for depression? I am currently taking 15-20mg qd and my depression is essentially resolved. Thanks

Outstanding!: Selegiline does work in selected patients. It is not the first choice or even the second or third. Thanks for the feedback. ...Read more

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If used concurrently could selegiline + clonidine have additive effect for ADHD?

If used concurrently could selegiline + clonidine have additive effect for ADHD?

Selegiline and: Clonidine have no known interactions so they are okay together. Clonidine may lower blood pressure while selegiline may interact with meds and foods with possible increase in blood pressure. Review interactions. Both have an effect in treatment of ADHD for some individuals and if they work for you then effects would be additive. Best regards for good health. ...Read more

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How does eldepryl (selegiline) manage symptoms of Parkinson's disease?

How does eldepryl (selegiline) manage symptoms of Parkinson's disease?

It boosts dopamine!!: Eldepryl is o/w called selegine or zelapar (oral-disintegrating form). It's a mao-i (mono amine oxidase inhibitor) which slows the breakdown of dopamine, the central chemical deficient in parkinson's. Thereby it boosts the natural Dopamine made by the brain or the synthetic Dopamine in sinemet. Thus, symptoms are more fully & consistently treated. Azilect (rasagiline) is a much better modern choice, however. ...Read more

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How can eldepryl (selegiline) work to manage symptoms of Parkinson's disease?

How can  eldepryl (selegiline) work to manage symptoms of Parkinson's disease?

Parkinson's Disease: Eldepryl (selegiline) is a selective monoamine oxidase inhibitor type b mao-i. It increases the Dopamine available in the barin by inhibiting the monoamine oxidase (a naturally occurring enzyme in the brain involved in removing the neurotransmitters Dopamine and serotonin from the extracellular space). ...Read more

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Is it safe to taking both Fluoxetine and selegiline?

Is it safe to taking both Fluoxetine and selegiline?

Interactions: There is concern that these medications together would cause a serotonin syndrome that could lead to cardiovascular collapse. However, in one 1994 study, patients on both these medications were found to have no serious side effects and no side effects that were found that were not in one of the medications alone. Still, many would advise not taking the medications together. ...Read more

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Any safety issues taking oral selegiline at 10mg daily for depression? I'm 21 and find this med more effective than ssris, any precautions 4 it ?

Any safety issues taking oral selegiline at 10mg daily for depression? I'm 21 and find this med more effective than ssris, any precautions 4 it ?

Just side effects: At 10 mg a day you should not encounter tyramine exposure related side effects. The common side effects include nausea, dizziness, dryness of the mouth, sleep disturbances, confusion, anxiety, hallucinations, and orthostatic hypotension. In your profile you mention drinking alcohol and as with any psychiatric medication you may want to refrain from alcohol to minimize behavioral disturbances. ...Read more

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Can selegiline become non selective inhibitor at 5mg dose.My blood pressure is abnormal now with high pulse rate at 5mg dose.It is 130-140/80-90 now.?

Can selegiline become non selective inhibitor at 5mg dose.My blood pressure is abnormal now with high pulse rate at 5mg dose.It is 130-140/80-90 now.?

At doses 20-40mg/day: Selegiline is non selective at higher doses 20-40mg/day with increase risk of hypertensive crisis. Changes in blood pressure can be seen at any dose depending on patient xteristics. Also watch for severe headache, stiff or sore neck, rapid heart , fainting, sweating, breathing problems. Please see your doctor as soon as possible to address these problems. Reduce/avoid alcohol while on selegiline. ...Read more

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What type if doctor prescribes selegiline.I foolishly tried to treat my depression with it(5mg) and good high pulse/bp even after quittng 3days ago.?

What type if doctor  prescribes selegiline.I foolishly tried to treat my depression with it(5mg) and good high pulse/bp even after quittng 3days ago.?

Local MD: You could start by seeing your local medical doctor. If you don't have one, try an urgent care center. I'm not sure you need to see a doctor who prescribes selegiline, rather, someone who can check you out and manage any reactions you are having. Like your local medical doctor to start with. Good luck. ...Read more

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Is selegiline a stimulant? Can I take it to improve my stress, wakefulness and fatigue? We do not have adderall, (dextroamphetamine and racemic amphetamine) provigil type drug in our country. I am looking for alternative.

Is selegiline a stimulant? Can I take it to improve my stress, wakefulness and fatigue? We do not have adderall, (dextroamphetamine and racemic amphetamine) provigil type drug in our country. I am looking for alternative.

Don't know : however why you need such medicines? Our goal is to find causes for your symptoms and treat. Please visit us www.ehacstl.com to learn how we propose to treat the cause. If interested you maybwant to make a tel consult or video conference. Hope it helps. Seligiline is for Parkinson's ...Read more

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I decided to use Selegeline 2.5mg daily as a smart drug. Is it safe for long term use?

Selegiline: is a drug used to treat Parkinson's disease and is not indicated for other use. You should using it as a smart drug and not be on it at all. We do not know what effects or long term effects it has on normal people. STOP AND DO NOT TAKE ANY MORE. ...Read more

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How long should it take for side effects to go a away after stopping 9mg Emsam? Also how long after stopping selegine should side effects subside.

How long should it take for side effects to go a away after stopping 9mg Emsam? Also how long after stopping selegine should side effects subside.

Emsam: This question gets a little tricky because Emsam is a patch and elimination can be delayed because of tissue uptake of the drug. Generally, the FDA has advised a wash out period of at least 5-7 days on average. Although the effects of the drug should diminish gradually before this amount of time. Hope that helps! ...Read more

Dr. James Dukelow
18 doctors shared insights

Eldepryl (Definition)

Eldepryl is a dopamine affecting agent which is a kind of anti-Parkinson's drug ...Read more