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Doctor insights on: Selective Estrogen Receptor Modulators

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Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


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Pregnenolone and aromatase blocker uses?

Pregnenolone and aromatase blocker uses?

Specific & limited: Pregnenolone is an adrenal hormone made from cholesterol, and is the pre-cursor for sex-steroid hormones. It is said to 'improve mood, ' but no strong data support. To my knowledge there is no role for it's use as a supplement. Aromatase inhibitors are for treatment of some breast cancers; they're also used off-label for ovulation induction in women. No other appropriate uses to my knowledge. ...Read more

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Are there any selective growth hormone receptor blockers?

Are there any selective growth hormone receptor blockers?

Yes: There is a drug called Pegvisomant (somavert) that works by directly blocks the effects of growth hormone, and has been shown to improve symptoms of acromegaly. There are two other drugs that are less specific in binding but can also be used to treat acromegaly: bromocriptine and octreotide. These are highly specialized drugs that should be prescribed by a physician. ...Read more

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Is stanozolol a beta receptor antagonist?

Is stanozolol a beta receptor antagonist?

Stanozolol: Stanozolol is a synthetic anabolic steroid derived from testosterone. It is banned from use in athletes but has a role in some medical conditions. Please look up stanozolol in Wikipedia on the internet. ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et.Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

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Do norepinephrine reuptake inhibitors suppress growth of brain?

Do norepinephrine reuptake inhibitors suppress growth of brain?

No: At this time, there is no evidence to suggest this. As one may imagine, few if any studies have been performed in humans to look for this. ...Read more

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What antidepressant medications selectively block neurotransmitters?

What antidepressant medications selectively block neurotransmitters?

Most newer ones: Most of the newer antidepressant medications affect specific neurotransmitters. Each does it slightly differently, accounting for the different response rates amongst them. The SSRI's primarily increase serotonin, the SNRI's both serotonin and norepinephrine, and buproprion mostly norepinephrine alone, and Brintellix affects many of them in different ways and in different places in the brain. ...Read more

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Evista (raloxifene) estrogen receptor for uterine cancer?

Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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Are brca hormone receptors?

Are brca hormone receptors?

No: Brca genes are important in repairing damaged dna. Mutations in these genes allow defective dna to replicate and turn the cells with defective dna into turmors. ...Read more

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Can working with NMDA receptor antagonists cause psychosis?

Can working with NMDA receptor antagonists cause psychosis?

Working with?: The nmda receptor agents are a new and exciting arae in the treatment of psychotic disorders. When added to current therapies it can help. But these effects must be monitored by your doctor and therapist and family (if available to give feedback). Laboratory and industrial exposure may cause untoward CNS activation in workers. Most labs have saftey standards for safe use of chemical process. ...Read more

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Is tamoxifen the same as aromatase inhibitor?

Is tamoxifen the same as aromatase inhibitor?

No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read more

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What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

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Side effects of angiotensin receptor blockers?

Generally : Well tolerated. Common side effects potentially include: dizziness, low blood pressure, headache, diarrhea, fatigue and elevated potassium to name a few. A serious side effect angioedema (swelling of throat/tongue etc) is relatively uncommon. ...Read more

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What are GABA antagonists that lead to gaba-a receptor up-regulation?

What are GABA antagonists that lead to gaba-a receptor up-regulation?

Not safe: GABA antagonists are not routinely prescribed for GABA A receptor upregulation. The main one flumazenil (clonazepam) is used for overdoses from benzodiazepines in an ER setting. It may cause withdrawal seizures. Your best bet is to detox and enter a drug tx program for alcohol or sedative-hypnotic dependence issues. ...Read more

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How do "serotonin antagonist and reuptake inhibitors" ssris work?

How do "serotonin antagonist and reuptake inhibitors" ssris work?

Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more

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What is the definition or description of: estrogen receptor?

What is the definition or description of: estrogen receptor?

See answer details.: An estrogen receptor is a protein found on some cells in the human body that is activated by the hormone estrogen. Once activated, the receptor sends a signal to the cell nucleus to activate certain genes. In breast cancer, the tumor is tested to determine if estrogen receptors are present on the malignant cells; if they are present, then anti-estrogen therapy is given as a part of the treatment. ...Read more

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What is estrogen receptor positive breast cancer?

What is estrogen receptor positive breast cancer?

One with receptors.: These are tumors with estrogen receptors on them. This makes them susceptable to some chemotherapeutic agents, like tamoxifen. ...Read more

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Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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What is meant by having estrogen receptor positive breast cancer?

What is meant by having estrogen receptor positive breast cancer?

Feeds the cancer: Most breast cancers are estrogen receptor positive. The cancer cells have receptors that fit the estrogen molecule that a body produces. Think: a lock and key - when estrogen binds to the receptor the tumor cell is stimulated to grow and divide. Er+ tumors can be blocked by tamoxifen and Arimidex (anastrozole) (and others) that interfere with this pathway. ...Read more

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Natural breast cancer remedies? I learned that estrogen-receptor blockers treat cancer, but what are some ER blockers?

Natural breast cancer remedies? I learned that estrogen-receptor blockers treat cancer, but what are some ER blockers?

I am not sure what u: Mean by "natural" but if u mean something other than what ur oncologist recommends u are putting urself at great risk of failed treatment. There have been great strides made in the treatment of breast cancer and the current therapies are well documented and successfully employed with thousands of patients every year. Feel free to obtain a second opinion but seek a proven treatmnt, not snakeoil. ...Read more

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Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

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My mom had estrogen receptor-positive breast cancer, should I be taking birth control or getting pregnant?

It is your choice.: Even a family history of breast cancer should not stop you from having kids, especially if you are healthy and cancer free. There are also several treatment options for estrogen receptor-positive breast cancer, like tamoxifen. Birth control is, of course, an option if you do not feel ready to have children yet, regardless of your family history. Get counseling from your doctor to be sure. ...Read more

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What are estrogen receptors? For someone with uterine fibroids?

What are estrogen receptors? For someone with uterine fibroids?

Receptors: Receptors are part of the cell that interact via messages or stimuli (in this case estrogen) and initiate a response due to a stimuli. Estrogen can cause fibroids to grow while in menopause, when there is lack of estrogen, the fibroids shrink Best wishes Dr M ...Read more

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What causes growth plates not to close by 25? Read for boys can be lack of estrogen receptors but what causes this in females who completed puberty?

What causes growth plates not to close by 25? Read for boys can be lack of estrogen receptors but what causes this in females who completed puberty?

Never seen it: Are you sure? Many growth plates leave a scar that can mimic an open plate, but rarely to the point that it fools a specialist. Can you post the xray? ...Read more

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How do you treat estrogen-, progesterone-, and her2/neu receptors. "triple negative" dcis? Is a mastectomy all you need? Do you need chemo?

How do you treat estrogen-, progesterone-, and her2/neu receptors. "triple negative" dcis?  Is a mastectomy all you need?  Do you need chemo?

Depends: On the pathology and the clinical presentations. You need to discuss this with the oncologist who will be managing your condition. These questions cannot be answered intelligently without seeing and evaluating you. Good luck. ...Read more

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Can you have estrogen-, progesterone-, and her2/neu receptors. "triple negative" with dcis? My mom had dcis with no chemo. Can you be triple negative

Yes: Receptor identification may be helpful in selection of therpeutic options. This may actually be a precancerous lesion which bears close watching. Hope she does well. ...Read more

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Clomid (clomiphene) is an estro receptor.Brain needs estrogen surge to release lh.Which means ppl on Clomid (clomiphene) don't have LH surge?How egg burst out?

Clomid (clomiphene) is an estro receptor.Brain needs estrogen surge to release lh.Which means ppl on Clomid (clomiphene) don't have LH surge?How egg burst out?

Got confused?: You are getting yourself confused. Clomid (clomiphene) is not an 'estro receptor' at all; it is mainly an estrogen receptor antagonist, but it has pro-estrogenic actions in some tissues and anti-estrogenic actions in others. Women on Clomiphene do mostly have an lh surge; not surging means the Clomiphene dose was likely too low. ...Read more

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Clomid (clomiphene) acts by blocking estrogen receptors,thus endometrium will thin out,how this can affect pregnancy rate and implantation of fertilized egg?

Clomid (clomiphene) acts by blocking estrogen receptors,thus endometrium will thin out,how this can affect pregnancy rate and implantation of fertilized egg?

Can effect: Thinning of the endometrial lining is one of the items monitored when fertility doctors give Clomid (clomiphene). This is also why it is only used for a few months in a row before stopping. Leutrozole is another option that can be used. ...Read more

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When the time comes, is it safe to take estrogen replacement therapy for menopause? I had estrogen/progesterone receptor positive endometrial cancer at 43, stage 1A. I tested negative for Lynch and am not overweight. My ovaries were not removed.

When the time comes, is it safe to take estrogen replacement therapy for menopause?  I had estrogen/progesterone receptor positive endometrial cancer at 43, stage 1A.  I tested negative for Lynch and am not overweight.  My ovaries were not removed.

Menopause and E2: If you have not gone through menopause at this point, your ovaries are producing much higher levels of estrogen than previous years. Stage 1A endometrial cancer is a result of hyper-stimulation of the endometrium. Low dose estrogen replacement after periods and all ovarian estrogen ceases, can be monitored by regular ultrasound exams, which will direct the treatment and safety. ...Read more

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Is it possible to have light periods even while u r estrogen dominant?

Clarify: what is estrogen dominant?- please clarify your question. Your cycles can be controlled with oral contraceptives and hormone levels. ...Read more

Estrogen Receptor (Definition)

An estrogen receptor is a protein found on some cells in the human body that is activated by the hormone estrogen. Once activated, the receptor sends a signal to the cell nucleus to activate certain genes. In breast cancer, the tumor is tested to determine if estrogen receptors are present on the malignant cells; if they are present, then anti-estrogen therapy is given as a ...Read more


Estrogen (Definition)

Estrogen is a hormone that is secreted by the ovaries and affects ovulation, ...Read more