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Doctor insights on: Selective Estrogen Receptor Modulator Serm

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Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more


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Evista (raloxifene) estrogen receptor for uterine cancer?

Evista (raloxifene) estrogen receptor for uterine cancer?

Unclear Question?: These are somewhat unrelated questions which makes it difficult for me to address your question. Evista (raloxifene) is not used for treating cancer...It is sued for treatment/prevention of osteoporosis. Estrogen receptors are specialised protein receptors found in breast cancer.Uterine cancer has little bearing on either of the two references you have listed. ...Read more

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Pregnenolone and aromatase blocker uses?

Pregnenolone and aromatase blocker uses?

Specific & limited: Pregnenolone is an adrenal hormone made from cholesterol, and is the pre-cursor for sex-steroid hormones. It is said to 'improve mood, ' but no strong data support. To my knowledge there is no role for it's use as a supplement. Aromatase inhibitors are for treatment of some breast cancers; they're also used off-label for ovulation induction in women. No other appropriate uses to my knowledge. ...Read more

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Is stanozolol a beta receptor antagonist?

Is stanozolol a beta receptor antagonist?

Stanozolol: Stanozolol is a synthetic anabolic steroid derived from testosterone. It is banned from use in athletes but has a role in some medical conditions. Please look up stanozolol in Wikipedia on the internet. ...Read more

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Is tamoxifen the same as aromatase inhibitor?

Is tamoxifen the same as aromatase inhibitor?

No: Tamoxifen belongs to a class of drugs called selective estrogen receptor modulators (serms). It works by blocking the binding of estrogen to estrogen receptors, thus disabling hormone-sensitive breast cancer cells. Aromatase inhibitors block the conversion of androgens to estrogens, effectively removing estrogen from the body (in postmenopausal women). ...Read more

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Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et.Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

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What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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Are there any selective growth hormone receptor blockers?

Are there any selective growth hormone receptor blockers?

Yes: There is a drug called Pegvisomant (somavert) that works by directly blocks the effects of growth hormone, and has been shown to improve symptoms of acromegaly. There are two other drugs that are less specific in binding but can also be used to treat acromegaly: bromocriptine and octreotide. These are highly specialized drugs that should be prescribed by a physician. ...Read more

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Do norepinephrine reuptake inhibitors suppress growth of brain?

Do norepinephrine reuptake inhibitors suppress growth of brain?

No: At this time, there is no evidence to suggest this. As one may imagine, few if any studies have been performed in humans to look for this. ...Read more

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Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Estrogen receptor ER positive breast cancer adjuvant Taxol (paclitaxel) benefits?

Get Oncotype: In order to answer this question, more details are needed (size of tumor, lymph node involvement, etc). A test that will help to decide if you need chemotherapy or not is the oncotype dx. I highly recommend you speak with your oncologist and even consider a 2nd opinion. ...Read more

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Are brca hormone receptors?

Are brca hormone receptors?

No: Brca genes are important in repairing damaged dna. Mutations in these genes allow defective dna to replicate and turn the cells with defective dna into turmors. ...Read more

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Does nolvadex (tamoxifen) decrease testosterone production in males?

Does nolvadex (tamoxifen) decrease testosterone production in males?

No: Nolvadex, a brand of tamoxifen, is a selective estrogen receptor modulator. As such, there are some small studies that suggest that it can actually increase testosterone production in med. Similarly, so can aromatase inhibitors which decrease conversion of t into e. Check out http://en.Wikipedia.Org/wiki/list_of_drugs_banned_from_the_olympics for a list of banned substances in competition & why. ...Read more

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Side effects of angiotensin receptor blockers?

Generally : Well tolerated. Common side effects potentially include: dizziness, low blood pressure, headache, diarrhea, fatigue and elevated potassium to name a few. A serious side effect angioedema (swelling of throat/tongue etc) is relatively uncommon. ...Read more

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Is there a androgen receptor blocker that only bind to pituitary?

Is there a androgen receptor blocker that only bind to pituitary?

No: There are ARs found all over the body. It's a type of nuclear receptor, that is, it binds to T or DHT in the cytoplasm and then translocates into the nucleus. ARB's like casodex will block AR's wherever they are. Enzalutamide has a greater affinity, prevents translocation & binding to DNA. You may be talking about LHRH agonists or antagonist for prostate cancer. Firmagon (degarelix) blocks in the pituitary. ...Read more

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Side effect of hormone replacement like estratest (esterified estrogens and methylestosterone)?

Side effect of hormone replacement like estratest (esterified estrogens and methylestosterone)?

Several.: If you have metabolic syndrome (bad cholesterol/hdl, high bp, weight on the middle, not for you. If you are more pear shaped, no effects ecept improving libido. The principle adverse effects relate to the estrogen. ...Read more

Estrogen Receptor (Definition)

An estrogen receptor is a protein found on some cells in the human body that is activated by the hormone estrogen. Once activated, the receptor sends a signal to the cell nucleus to activate certain genes. In breast cancer, the tumor is tested to determine if estrogen receptors are present on the malignant cells; if they are present, then anti-estrogen therapy is given as a ...Read more


Estrogen (Definition)

Estrogen is a hormone that is secreted by the ovaries and affects ovulation, ...Read more