Doctor insights on:
Does infectious disease specialist treat or study systemic scleroderma. Undifferentied diffuse connective tissue disease,raynauds?
No: these are generally dealt with by rheumatologists. Good luck. ...Read more
Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?
Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read moreSee 1 more doctor answer
PM/Scl: The paradox of rheumatologic diseases is that there are more lab tests in this area than any other, and they of relatively less value compared to the history and physical findings than in other fields. If your rheumatologist is comfortable with the diagnosis of "scleromyositis", which usually features anti-pm/scl, i'd accept it even with a single negative result, and proceed. ...Read more
Biopsy: Confirmatory test is biopsy via upper GI endoscopy and/or colonoscopy. Crohn's usually presents with inflammatory changes and granulomas (areas of immune system consolidation) at the end of the small intestine (terminal ileum) but it can involve any part of the GI tract. ...Read moreSee 1 more doctor answer
How/why can lupus symptoms present & diagnosis of lupus be made by clinical picture &high ANA titer only?Why don't other labs show positive?Two rheum mds dx'd me.
S L E : Systemic lupus erythematosus is an auto immune disease, that can affect skin, joints, kodneys, brain, and other organs.Auto immune means bodys immune system mistakenly attacks healthy tissues it is treated with steroids and non steroidal anti inflammatory meds, avoid sun and wear protective clothing. Cytotoxic drugs if you do not respond to cortico steroids cytotoxics have side effects need to be monit. ...Read moreSee 1 more doctor answer
Whats standard infectious workup post POTS diagnosis? Does typical workup include Lyme disease testing?
Autoimmune disease: A disease in which your body makes antibodies against your own cells. These antibodies cause destruction and inflammation which produce a wide variety of symptoms depending on what cells are being injured. There are some common symptoms and signs with the disease, but just about any symptom could be produced by lupus. ...Read moreSee 1 more doctor answer
Any physician: It depends on the expertise. As a rheumatologist we may not necessarily have a corner on the market, but depending on what signs and symptoms the patient has they may be diagnosed by other physicians. It is important to be clear what the true diagnosis is since mctd people can have skin, joint, muscle, lung, heart, kidney involvement to name some. It depends on the stage of the mctd. ...Read more
Hydrops fetalis (HF): Hf is divided into two major categories: immune hf and nonimmune hf. Immune hydrops fetalis is caused by rh incompatibility, and used to be the most common cause. All other causes of hf are termed non-immune and may be caused by chromosomal aberrations, other genetic disorders, infections, anemias, structural birth defects such as congenital heart disease, and many other causes. ...Read more
Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read moreSee 1 more doctor answer
No real criteria: Typical appearance would suffice for diagnosis.Get a more detailed answer ›