Top
20
Doctor insights on: Scleroderma Diagnosis

Share
Dr. Pierre Moeser
185 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


3

3
Is scleroderma curable?

Is scleroderma curable?

No: Many of the manifestations of scleroderma are treatable including the circulatory disorder called raynaud's phenomenon. Even the skin problem has improved in some patients. Ultimately, the disease is not curable but can be treatable. ...Read more

See 1 more doctor answer
4

4
Is a diagnosis of Crohn's disease accurate without biopsy?

Crohn's: it is not completely possible to diagnose Crohn's without biopsy. ...Read more

5

5
Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy  give more definitive diagnosis?

Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read more

See 1 more doctor answer
6

6
Is scleroderma genetic?

Is scleroderma genetic?

Yes: In certain groups such as the choctaw population in oklahoma there is a strong genetic component. There is also a difference in populations between the different continents. ...Read more

See 1 more doctor answer
7

7
Positive diagnosis (scleroderma, polymyositis) with negative blood tests? Is that common?

Positive diagnosis (scleroderma, polymyositis) with negative blood tests?  Is that common?

PM/Scl: The paradox of rheumatologic diseases is that there are more lab tests in this area than any other, and they of relatively less value compared to the history and physical findings than in other fields. If your rheumatologist is comfortable with the diagnosis of "scleromyositis", which usually features anti-pm/scl, i'd accept it even with a single negative result, and proceed. ...Read more

8

8
What test diagnoses Crohn's disease?

What test diagnoses Crohn's disease?

Biopsy: Confirmatory test is biopsy via upper GI endoscopy and/or colonoscopy. Crohn's usually presents with inflammatory changes and granulomas (areas of immune system consolidation) at the end of the small intestine (terminal ileum) but it can involve any part of the GI tract. ...Read more

See 1 more doctor answer
11

11
What makes systemic scleroderma flare?

What makes systemic scleroderma flare?

Stress: There are no specific triggers to avoid if you have the condition. However, internal or external stress often precede a flare of scleroderma. ...Read more

See 1 more doctor answer
12

12
What is treatment for systemic lupus erythematosus?

What is treatment for systemic lupus erythematosus?

S L E : Systemic lupus erythematosus is an auto immune disease, that can affect skin, joints, kodneys, brain, and other organs.Auto immune means bodys immune system mistakenly attacks healthy tissues it is treated with steroids and non steroidal anti inflammatory meds, avoid sun and wear protective clothing. Cytotoxic drugs if you do not respond to cortico steroids cytotoxics have side effects need to be monit. ...Read more

See 1 more doctor answer
13

13
Whats standard infectious workup post POTS diagnosis? Does typical workup include Lyme disease testing? ,

Whats standard infectious workup post POTS diagnosis? Does typical workup include Lyme disease testing?
,

Yes: Lyme can cause autonomic dysfunction including POTS- good idea to get tested for lyme and its coinfections such as bartonella, mycoplasma, erhlichia, anaplasma, babesia and rocky mountain spotted fever which are all tick borne infections ...Read more

14

14
Can preimplantation genetic diagnosis testing work on diagnosising ataxia telangiectasia?

Can preimplantation genetic diagnosis testing work on diagnosising ataxia telangiectasia?

Perhaps: It is a genetic disorder with the parents acting as carriers. Atcp.Org might be a good starting place to investigate genetic counseling prior to conception and try to evaluate your risk. ...Read more

15

15
Systemic lupus erythematosus--what is sle?

Systemic lupus erythematosus--what is sle?

Autoimmune disease: A disease in which your body makes antibodies against your own cells. These antibodies cause destruction and inflammation which produce a wide variety of symptoms depending on what cells are being injured. There are some common symptoms and signs with the disease, but just about any symptom could be produced by lupus. ...Read more

See 1 more doctor answer
16

16
What specialists can diagnose mixed connective tissue disease besides rheumatologists?

What specialists can diagnose mixed connective tissue disease besides rheumatologists?

Any physician: It depends on the expertise. As a rheumatologist we may not necessarily have a corner on the market, but depending on what signs and symptoms the patient has they may be diagnosed by other physicians. It is important to be clear what the true diagnosis is since mctd people can have skin, joint, muscle, lung, heart, kidney involvement to name some. It depends on the stage of the mctd. ...Read more

17

17
Differential diagnosis for fetus with hydrops?

Differential diagnosis for fetus with hydrops?

Hydrops fetalis (HF): Hf is divided into two major categories: immune hf and nonimmune hf. Immune hydrops fetalis is caused by rh incompatibility, and used to be the most common cause. All other causes of hf are termed non-immune and may be caused by chromosomal aberrations, other genetic disorders, infections, anemias, structural birth defects such as congenital heart disease, and many other causes. ...Read more

18

18
What gene causes lupus erythematosus?

What gene causes lupus erythematosus?

Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read more

See 1 more doctor answer
19

19
Is lupus erythematosus infectious?

No: Is a immune based disease does not recognize self and attacks multiple organs. ...Read more

Dr. Sanjiv Kaul
144 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more