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Doctor insights on: Scleroderma Antibodies

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15

Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15

Doubt scleroderma: We'd rather that a 24 hour urine sample contain 150 mg or less of protein; you haven't given us the sample type. Several percent of people have protein in their urine just from standing up, and this needs to be ruled out before anybody gets all worried about her kidneys. Unlike lupus, scleroderma isn't a famous cause of proteinuria, but rather of renovascular hypertension. Stay proactive. ...Read more

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I try to avoid toxic drugs and treatments. What can I try before I go for traditional medical care for circumscribed scleroderma?

NOT AS SEVERE: Scleroderma is a fascinating disease and has 3 main types, diffuse, limited and localized also known as morphea. Diffuse scleroderma is the most severe. Circumscribed scleroderma or morphea tends to mean a localized area of thickened skin. This tends to be less severe with few compications of other organs which is typical of diffuse scleroderma. Treament is limited. ...Read more

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Does any one out there know about morphea scleroderma?

Does any one out there know about morphea scleroderma?

YES SEE BELOW: Morphea is a medical term for localized scleroderma. The disease involves isolated patches of hardened skin - there generally is no internal organ involvement. ...Read more

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Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15

Doubt scleroderma: We'd rather that a 24 hour urine sample contain 150 mg or less of protein; you haven't given us the sample type. Several percent of people have protein in their urine just from standing up, and this needs to be ruled out before anybody gets all worried about her kidneys. Unlike lupus, scleroderma isn't a famous cause of proteinuria, but rather of renovascular hypertension. Stay proactive. ...Read more

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I have had scl70 antibodies for scleroderma sine scleroderma. Now I have severe shortness of breath, tightness in my chest, body aches and dizziness. ?

Would also be: I would be concerned about interstitial lung disease secondary to scleroderma as well pulmonary hypertension as the blood clots mentioned by colleague. You need to see your rheumatologist to have a workup performed in order to confrim or rule out what you may have. ...Read more

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I have lupus- diagnosed w/labs and symptoms.But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

I have lupus- diagnosed w/labs and symptoms.But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

Rheumatologist. ...: You need to see a rheumatologist to sort out the lupus question. Lots of symptoms but zero lab evidence may not necessarily be lupus. Make sure diagnosis is right! ...Read more

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Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies?no raynauds,but bad GERD w/ PPI's not workin, I have lupus

History / physical: Scleroderma is diagnosed on history and physical exam. Without Raynaud's, it's unlikely. The labs aren't altogether sensitive. I'd address the GERD as a separate issue, and continue as you're probably already doing keeping a close eye on your lupus as a proactive patient. Best wishes. ...Read more

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How many people die from scleroderma?

How many people die from scleroderma?

Rare disease: Scleroderma is a very rare autoimmune disease which often results in a progressive decline in health resulting in death, due to the fact that little or no treatment options exist for scleroderma. It is quite rare, among the rarest of all immune complex diseases. ...Read more

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What makes systemic scleroderma flare?

What makes systemic scleroderma flare?

Stress: There are no specific triggers to avoid if you have the condition. However, internal or external stress often precede a flare of scleroderma. ...Read more

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What are the 1st symptoms of scleroderma?

Tight skin: Early in the disease: fatigue, joint pain, tightening of the skin, and raynaud's phenomenon. ...Read more

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What are the possible symptoms of scleroderma?

Tight skin: Tight skin is characteristic but there can be a variety of other symptoms such as raynaud's, shortness of breath, chest pain, trouble swallowing, other GI symptoms, etc. Each person with scleroderma has a different set of symptoms and different type of scleroderma involvement. ...Read more

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What are the symptoms of scleroderma in a man?

The same like women: Scleroderma is a rare disease. Fewer than 500, 000 people in the United States have scleroderma. No one knows for sure why or how it develops. Some experts report that six out of seven patients are women. ...Read more

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If you get scleroderma, what are your symptoms?

If you get scleroderma, what are your symptoms?

Scleroderma symptoms: There are different types of sclerodema; one type may only be confined to the skin. Another type, called limited scleroderma, is frequently associated with food sticking or heart burn. Systemic sclerosis, the most severe, may be aassociated with shortness of breath with exertion, severe headache from very high blood pressure, weight loss from poor absorption of food, among others. ...Read more

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What is the definition or description of: Scleroderma?

Scleroderma: Scleroderma is an autoimmune disease and which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect kidneys and other organs. This is one disease in which a specialist such as a rheumatologist should be involved in your care. I am happy to do a consult if needed. ...Read more

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What are the first symptoms of someone with scleroderma has?

Scleroderma: Localised scleroderma (also known as morphoea). This only affects the skin. It causes some areas of the skin to become harder than usual.Systemic sclerosis. This causes some areas of the skin to become harder than usual, and it may involve one or more of the body's internal organs.Systemic sclerosis is an autoimmune disease.http://patient.info/health/scleroderma-systemic-sclerosis ...Read more

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What is morphea also scleroderma?

What is morphea also scleroderma?

Sort of: Morphea is a localized patch of scleroderma (hard skin) that is generally not associated with the systemic manifestations of scleroderma or systemic sclerosis. ...Read more

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What is scleroderma crest variant?

Limited : The limited cutaneous form of systemic sclerosis is also referred to as crest syndrome. "crest" is an acronym for calcinosis, raynaud's syndrome, esophageal dysmotility, sclerodactyly, and telangiectasia. ...Read more

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What are the early signs of scleroderma?

What are the early signs of scleroderma?

Raynaud's Syndrome!: Raynaud's syndrome is most common, blanching of the last 2/3rds of the digits of the hand with cold, stress, or fear most common. Thickening of the skin of hands (sclerodactaly) is the second most common. Food sticking in the throat is another early sx. However some people can get early pulmonary or renal problems at the same time, or even before these other occur. If you have these, see a rheum. ...Read more

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Is my polymyositis related to scleroderma?

Is my polymyositis related to scleroderma?

Polymyositis: Polymyositis & scleroderma are both significant connective tissue disorders that both have autoimmune/ rheumatologic component. You need management by rheumatologist, at least to optimize the conditions. ...Read more

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What is thw best diet for scleroderma patients?

What is thw best diet for scleroderma patients?

Can be hard problem: No simple answer. Scleroderma patients can have problems with chewing (soft diet helps), esophageal issues (poor contractions, lots of reflux-avoid fried, greasy, fatty, spicy foods, large meals, lying down after eating, chocolate, minimize coffee); can have diverticula and bacterial overgrowth in small bowel-causes diarrhea-may need episodic antibiotics; probiotics may help.
C doc and dietician. ...Read more

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Which treatment works the best and fastest for scleroderma?

Which treatment works the best and fastest for scleroderma?

Scleroderma: Scleroderma is a connective tissue disease (ctd). The best treatment is based on treating the affected system or organ cause. For instance: ctd may be manifested as pulmonary hypertesnion, lupus, esophageal narrowing, kidney disease. Is so hard to explain on the internet, but better to understand and explain if i;m able to examine you and do the proper work up and referrals. ...Read more

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Can i drink wine if I have scleroderma?

Yes: Drinking a glass of wine per day is actually good for you unless you have underlying liver disease. Wine does not hurt or help in scleroderma. ...Read more

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Are canker sores common with scleroderma?

Indirectly: Some of the meds used to treat scleroderma can possibly lead to mouth sores. ...Read more

Dr. Pierre Moeser
185 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


Dr. James Krick
144 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis = scleroderma = autoimmune disease affecting connective tissue & blood vessels. It causes skin to thicken asymmetrically due to deposits of fibrous connective ...Read more