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Doctor insights on: Scleroderma Antibodies

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Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15

Doubt scleroderma: We'd rather that a 24 hour urine sample contain 150 mg or less of protein; you haven't given us the sample type. Several percent of people have protein in their urine just from standing up, and this needs to be ruled out before anybody gets all worried about her kidneys. Unlike lupus, scleroderma isn't a famous cause of proteinuria, but rather of renovascular hypertension. Stay proactive. ...Read more

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I try to avoid toxic drugs and treatments. What can I try before I go for traditional medical care for circumscribed scleroderma?

NOT AS SEVERE: Scleroderma is a fascinating disease and has 3 main types, diffuse, limited and localized also known as morphea. Diffuse scleroderma is the most severe. Circumscribed scleroderma or morphea tends to mean a localized area of thickened skin. This tends to be less severe with few compications of other organs which is typical of diffuse scleroderma. Treament is limited. ...Read more

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Does any one out there know about morphea scleroderma?

Does any one out there know about morphea scleroderma?

YES SEE BELOW: Morphea is a medical term for localized scleroderma. The disease involves isolated patches of hardened skin - there generally is no internal organ involvement. ...Read more

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Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15

Doubt scleroderma: We'd rather that a 24 hour urine sample contain 150 mg or less of protein; you haven't given us the sample type. Several percent of people have protein in their urine just from standing up, and this needs to be ruled out before anybody gets all worried about her kidneys. Unlike lupus, scleroderma isn't a famous cause of proteinuria, but rather of renovascular hypertension. Stay proactive. ...Read more

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I have had scl70 antibodies for scleroderma sine scleroderma. Now I have severe shortness of breath, tightness in my chest, body aches and dizziness. ?

Would also be: I would be concerned about interstitial lung disease secondary to scleroderma as well pulmonary hypertension as the blood clots mentioned by colleague. You need to see your rheumatologist to have a workup performed in order to confrim or rule out what you may have. ...Read more

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I have lupus- diagnosed w/labs and symptoms.But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

I have lupus- diagnosed w/labs and symptoms.But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

Rheumatologist. ...: You need to see a rheumatologist to sort out the lupus question. Lots of symptoms but zero lab evidence may not necessarily be lupus. Make sure diagnosis is right! ...Read more

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Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies?no raynauds,but bad GERD w/ PPI's not workin, I have lupus

History / physical: Scleroderma is diagnosed on history and physical exam. Without Raynaud's, it's unlikely. The labs aren't altogether sensitive. I'd address the GERD as a separate issue, and continue as you're probably already doing keeping a close eye on your lupus as a proactive patient. Best wishes. ...Read more

Dr. Suzanne Galli
136 doctors shared insights

Dermatosclerosis (Definition)

Dermatosclerosis (also known as scleroderma), is a disease of the connective tissue, causing tightening and ...Read more


Dr. Pierre Moeser
177 doctors shared insights

Scleroderma (Definition)

Scleroderma is an autoimmune disease characterized by tightening of the skin on ...Read more