Doctor insights on:
Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read moreSee 1 more doctor answer
Is crest syndrome with high centromere b antibody considered a rare disorder with rheumatologists having only a few such patients? Should i seek out a scleroderma specialty center for regular care?
Seizures mouth ulcers hepatocellular disease low blood count anticardiolipin antibodies 1:80 speckled ANA osteoarthritis spine Si joints LUPUS maybe?
My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?
Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?
Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read moreSee 1 more doctor answer
What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more
downs,systemic rheumatoid arthritis, anemia tsh t4 normal has thyriod antibodies hyperthyroid why
Autoimmune disorders: like Rheumatoid Arthritis, diabetes & thyroiditis have an ^ed incidence in children with Down Syndrome (DS). A normal Free T4 & ^ed Ultrasensitive TSH indicates sub-clinical HYPOthyroidism that can become clinical. Macrocytosis, large RBC's, in infants with DS remains lifelong in 2/3rds. It can be associated with anemia from low Vitamin B12 & Folate (folic acid) or iron levels, hypothyroidism or leukemia. ...Read moreSee 1 more doctor answer
Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?
Many genes: The previous answer is right with several genes associated with lupus, but no one knows how those genes cause disease. I think it's important to remember that there is likely many ways to develop lupus symptoms, and this will vary between people. So some of these known genes will be important for some, and not important for others. As we sequence more patients, we'll have more answers. ...Read moreSee 1 more doctor answer
Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?
Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more
Lily is testing for scleroderma. Her antibodies came back negative, she had 100 mg of protein in her one-time urine sample. Is that very high? Sheis15
Doubt scleroderma: We'd rather that a 24 hour urine sample contain 150 mg or less of protein; you haven't given us the sample type. Several percent of people have protein in their urine just from standing up, and this needs to be ruled out before anybody gets all worried about her kidneys. Unlike lupus, scleroderma isn't a famous cause of proteinuria, but rather of renovascular hypertension. Stay proactive. ...Read more
Ana direct positive ANA , ifa neg , rnp 2.3, CRP 5.4 ss-b2.7.Diag with lupus connective tissue and sjorgen all at once? Why 2 ANA tests different answ
They can change!: Appears you have mctd with sjogren's like features based on the labs and titers. No lupus marker present! ...Read more
RA and lupus antibod: If the arthritis looks like RA and the RA antibodies are negative , the disease usually is less erosive and less distrctive to joints and can acrue more symptoms and signs of lupus. If the rheumatoid factor or ccp are positive, that makes the disease act more like ra. ...Read more