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Doctor insights on: Savage Cd Key

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Nhl grade 3a stage 1, 6 cycles of rchop-21 and igrt 30 gy taken. Is rituximab maintenace therapy required further?

Nhl grade 3a stage 1, 6 cycles of rchop-21 and igrt 30 gy taken. Is rituximab maintenace therapy required further?

Maintenance therapy: ...with rituximab is commonly given for follicular lymphoma, but not so much for other types of NHL (non-Hodgkins Lymphoma). Rituximab maintenance forestalls the the recurrence of the disease, but does not necessarily make patients live longer; because they could also wait and get rituximab a 2nd time when there disease relapses. ...Read more

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Marrow aspirate flow cytometry. Whats importance of the dominant markers in lymphocyte vs. blast gates? Eg. Lymph CD2~5~7~38 Blast 22~34~45~117~hladr

Marrow aspirate flow cytometry. Whats importance of the dominant markers in lymphocyte vs. blast gates? Eg. Lymph CD2~5~7~38 Blast 22~34~45~117~hladr

Exactly400Characters: I'm not here to answer.This is beyond my expertise. But I would like to remind you,& others,that we are restricted to 400 characters(not words,but individual letters,etc).I would suspect that a question like this would require some more information before someone would want to commit to an answer and,anyways,the person who ordered and/or did the aspirate should be consulted for definitive answers. ...Read more

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Can hodgkin lymphoma transform to NHL? After 4 cycle of ABVD, PET showed an area with SUV 14. Initial diagnosis was HL IIb, bulky.

Can hodgkin lymphoma transform to NHL? After 4 cycle of ABVD, PET showed an area with SUV 14. Initial diagnosis was HL IIb, bulky.

Yes it can: This change has been reported, so it is entirely possible. But only a biopsy of the new area or the growing lymph node can determine what is going on. Your oncologist should be able to help address this matter for you. Or you can seek a second opinion from another medical oncologist, if you are not totally satisfied with your current oncologist. ...Read more

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What is the treatment of chondromalacia patellae grade 3 to early 4? I read about arthroscopy and platelet-rich plasma and Stem cell transplantaion.

What is the treatment of chondromalacia patellae grade 3  to early 4?  I read about arthroscopy and platelet-rich plasma and Stem cell transplantaion.

Tough problem: First try all of the conservative options: bracing, therapy, steroid injections, viscosupplemention injections (synvisc, Supartz, (hyaluronic acid) etc). If this fails then sometimes an arthroscopy may help. The science is still out on PRP. ...Read more

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Hi, What chances of cancer by doing Autologous Adipose derived stem cell treatment.Pls help.thanks?

Hi, What chances of cancer by doing Autologous Adipose  derived stem cell treatment.Pls help.thanks?

Not much: There isnt much but this depends on the context of why there is the transplant. It is used either in cancer http://www.wjgnet.com/1948-9366/full/v8/i2/161.htm or reconstructive surgery. In someone without cancer, they dont even do studies to evaluate risk since the risk is assumed zero. ...Read more

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Best first-line treatment for mantle cell lymphoma now: high doses of ara-c+rituximab and autologous sc transplant, or rituximab+bendamustine?

Best first-line treatment for mantle cell lymphoma now: high doses of ara-c+rituximab and autologous sc transplant, or  rituximab+bendamustine?

There is no: Definitive answer to your question. Studies have compared the strategies you mention. The high dose ara-c arm was closed because it was difficult to mobilize stem cells for transplant after these regimens. Bendamustine-r is a good program, and many centers would consolidate a good response with an autograft. ...Read more

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What is the goal/ predicted outcome of autologous stem cell transplantation studies for ms?

What is the goal/ predicted outcome of autologous stem cell transplantation studies for ms?

Multiple sclerosis : Researchers are optimistic. Yet, no proven efficacy as of yet. Mortality is down to 1-2%. Check following site: http://www.Ncbi.Nlm.Nih.Gov/m/pubmed/18565456/. ...Read more

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What the different between salvage therapy hiv and salvage therapy h.pylori ? I'm confusing now.

What the different between salvage therapy hiv and salvage therapy h.pylori ? I'm confusing now.

No relationship: The term is not commonly used in medicine. "Salvage therapy" just means a treatment that can be tried if a patient failed to resolve his illness after getting the standard, commonly-used treatment(s). Looking at it this way, every disease has a salvage therapy, unless there is no other hopeful treatment to try. ...Read more

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May i know the simple explanation for this diagnosis: (post auricular area), excision biopsy: cellular spindle cell lesion favor nodular fascitis?

May i know the simple explanation for this diagnosis: (post auricular area), excision biopsy: cellular spindle cell lesion favor nodular fascitis?

Get 2nd opinion: A pathologist who trained at one of my institutions self-diagnosed a sarcoma and had his arm amputated, only to discover later it was nodular fasciitis, which is very benign. I was trained by some of the great pathologists and even they said they'd never call nodular fasciitis without a second pathologist agreeing. I'd suggest showing 3-4 of us pathologists. Good luck. ...Read more

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Can a 20mm follicle ovulate on cd 25 with the help of injections?

Can a 20mm follicle ovulate on cd 25 with the help of  injections?

Maybe: But it's possible that a reproductive endocrinologist would avoid triggering a follicle that late in your cycle. Slow-growing or late follicles are not felt to be as healthy. Also the endometrial lining may not be as receptive. It also depends on what was happening leading up to that cycle day. ...Read more

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Diagnosis. B.Cell non hodgkin, s lymphoma favor burkitt, s lymphoma. This us the result of biopsy taken during appendicectomy. D20 positive and tdt neg?

Diagnosis. B.Cell non hodgkin, s lymphoma favor burkitt, s lymphoma. This us the result of biopsy taken during appendicectomy. D20 positive and tdt neg?

CD20 is a B-Cell: Marker hence the assignment of a b-cell nhl. Tdt is an immunohistochemical stain used to classify blood cells. Burkitt's is a very aggressive process -- get started on a plan with a hematologist straight away. ...Read more

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Took Clomid (clomiphene) 100mg cd3-7,trigger shot cd 11. 7 mature follicles. IUI cd12 30hrs post trigger & cd 13 49hrs post trigger. What would adding FSH cd9 do?

Took Clomid (clomiphene) 100mg cd3-7,trigger shot cd 11. 7 mature follicles. IUI cd12 30hrs post trigger & cd 13 49hrs post trigger. What would adding FSH cd9 do?

CC/IUI: Some stimulation protocols combine CC with small doses of hMG/FSH added later. These protocols are a little bit arbitrary, meaning they reflect "recipes" that an individual doctor has found helpful, not a general practice. You'd need to ask your own doctor why he/she wants the FSH on CD9. ...Read more

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7 yrs. Post tx bro w/ ptld b cell cd 20. Ritux w/ poor result, 4 rchop infusions produced clean scan, bad effects. How many more needed?

7 yrs. Post tx bro w/ ptld b cell cd 20.   Ritux w/ poor result,  4 rchop infusions produced clean scan, bad effects. How many more needed?

Need more info: Can't advise from question. Need more details on disease, stage, treatment, and side effects experienced. ...Read more

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10% lymphocytes positive cd20, cd3 cd79a negative for cd10. Results indicate a mixed b and t cell phenotype and thus consistent with reactive nature?

10% lymphocytes positive  cd20, cd3 cd79a negative for cd10. Results indicate a mixed b and t cell phenotype and thus consistent with reactive nature?

See below: If the pathology report didn't indicate monoclonality or lymphoproliferative disorder, it means that probably it is not lymphoma. ...Read more

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How much helpful is stem cell therapy for the treatment of talus avn? ?

How much helpful is stem cell therapy for the treatment of talus avn? ?

None: Unfortunately at this time there isn't enough studies with stem cells working on bone though research is ongoing. Suggest to check if the rest of the limb has normal blood flow. If it does more time may be your answer. ...Read more

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Success rate for mastectomy retaining flap and nipple no sentinel node invasion stage 1b measures 8mm, margins good except anterior 1.5mm? Must chemo?

Success rate for mastectomy retaining flap and nipple no sentinel node invasion stage 1b measures 8mm, margins good except anterior 1.5mm? Must chemo?

Tumor genetics: You could request a recurrence score which is a genomic evaluation of tumor cell gene s. 2 common tests in U.S. Are oncotype DX and mammaprint. ...Read more

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Does monoclonal b-cell lymphocytosis make the patient more vulnerable to infections, e.G., hypostatic pneumonia? Is monoclonal b-cell lymphocytosis capable of transforming into acute leukemia?

Does monoclonal b-cell lymphocytosis make the patient more vulnerable to infections, e.G., hypostatic pneumonia?  Is monoclonal b-cell lymphocytosis capable of transforming into acute leukemia?

No infections in MBL: The definition of mbl is an elevated lymphocyte count with a lack of symptoms or complications. It can transform into cll (chronic lymphocytic leukemia), in which low immunoglobulins and the abnormal b lymphocytes can indeed cause increased infections. Neither of these has been associated with transformation to acute leukemia, although cll can become an aggressive lymphoma. ...Read more

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