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Doctor insights on: Sarcoma Metastasis

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How can metastasis occur?

How can metastasis occur?

3 factors: The tumor must produce matrixmetalloproteinase (MMP) to allow entry into the blood stream. The MMP must breakdown -cadherin to small e cadherin for progression of tumor growth and new cells invading circulation must express a surface antigen that determins site of implantation. Ovary spread to omentum where TGF beta present, Colon to liver because matrix contains liver ferritin. ...Read more

Dr. Lawrence Kessler
2 doctors shared insights

Sarcoma (Definition)

By definition, it is malignant (i.e., being locally invasive and at least theoreticlally capable of metastasizing), and arises from / mimics muscle or connective tissue elements that are not marrow or immune / white cells. The sarcomas are a tremendously varied and troublesome family of tumors, though thankfully less common than carcinomas and the leukemia / ...Read more


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How can cancer metastasis work?

How can  cancer metastasis work?

Different results: Metastasis arises from primary, the former being clonal and the primary, polyclonal. What spreads to a site such as liver or lung can only grow within that parenchyma and never spread elsewhere. The primary has multiple clones each only capable of spreading to a local site and growing there. Thus primary should always be removed and met focal disease treated later for best survival. ...Read more

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How is colorectal metastasis detected?

How is colorectal metastasis detected?

CT/surgery.: These are often detected on ct scan, but the most definitive way to detect this is by surgery, often done during resection of primary tumor. This is one reason why the dukes classification is used, as the invasiveness is determined at surgery. Stage a - to submucosa, b - to muscularis, c - to lymph nodes, d - distant metastasis. Organs of metastasis also show signs - liver, bone lung. ...Read more

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What problems are caused by bone metastasis?

What problems are caused by bone metastasis?

Pain: Pain is by far the most common symptom. Less commonly, a fracture may be the cause for discovery and rarer still paralysis from spinal cord compression with vertebral involvement. ...Read more

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How are a cancerous tumor and metastasis different?

How are a cancerous tumor and metastasis different?

Cancer & metastasis: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems. When these cancer cells spread beyond the primary organ- we call this metastasis. ...Read more

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How would angiogenesis influence tumor growth and metastasis?

How would angiogenesis influence tumor growth and metastasis?

Fundamental!: All living things need a blood supply to deliver food, water, and get rid of waste. A circulating cancer cell needs to evade detection, get out of the blood vessel, and establish that blood supply: angiogenesis!. All these actors under molecular control, and likely normal during in utero development. Cut off the blood supply, choke the tumor. ...Read more

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How long would someone have to live if their cancer is metastasis?

How long would someone have to live if their cancer is metastasis?

It varies : This is often a very difficult, if not impossible, question to answer for patients. Knowing someone's cancer type and stage and overall health, we can look at statistics of comparable patients and provide estimates of response to therapy, but this is, at best, an educated guess. Statistics are for populations, not for individuals--what does someone look like who has "70% survived" a cancer? ...Read more

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What is metastasis and at what stage of cancer would it start to occur?

What is metastasis and at what stage of cancer would it start to occur?

Cancer spread. : Metastasis is the spread of cancer from the place that it formed to other organs in the body. This usually is a bad sign prognostically, indicating more aggressive behavior. Some cancers can metastasize early, and others rarely do. The "stage" of cancer is determined by multiple factors, depending on the type of cancer. The presence of metastases often means a higher stage, worse prognosis. ...Read more

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Metastasis (Definition)

A cancer begins in an organ (say the breast). If it gets into the blood stream or the lymphatic stream the cells can travel to other parts of the body where, in the right environment, they may settle and grow. This development of tumor growth far away from the original site ...Read more