Doctor insights on:
S There Difference Between Indirect And Direct Coombs Test
Yes: The direct Coombs test is typically used to test for autoimmune hemolytic anemia, a disorder involving destruction of red blood cells. It determines whether or not antibodies are present on the surface of the patient's rbcs. The indirect Coombs test is typically used to test for blood type compatibility prior to a transfusion, and detects the presence of antibodies in the serum of the patient. ...Read more
Coombs serum is an antibody directed against other antibodies that makes antibody-coated red cells stick together. The direct Coombs test seeks antibodies on a patient's own red cells that may be causing red cell damage and perhaps anemia. The indirect Coombs test is used in blood banking to determine what antigens are present on unknown red cells by seeing ...Read more
Bound vs unbound ABs:
Direct coombs' test is used to detect antibodies that are already bound to the surface of red blood cells. Many diseases and drugs (quinidine, methyldopa, and procainamide) can lead to production of these antibodies
indirect coombs' test looks for unbound circulating antibodies against a series of standardized red blood cells. The indirect coombs' test is only rarely used to diagnose a condition. ...Read more
Both test Ag-Ab rxns:
Direct Coombs will test for the reaction using the patient’s RBCs, if there is a reaction, then the direct test is positive, used to test for autoimmune hemolytic anemia.
Indirect Coombs test uses the patient’s serum (not rbcs) which is added to rbcs that are known to have a certain antigenicity, positive in cases of hemolytic diseases of the newborn, mother's serum against baby's RBCs, ...Read more
RBC antibodies: These tests are used to detect antibodies against red blood cells (rbcs). The direct Coombs test is used in autoimmune hemolytic anemia. That's when your antibodies attack & destroy you own rbcs. The indirect test is used to detect potential transfusion reactions & in pregnancy especially for rh incompatibility when mom is rh- & fetus is rh+. For a more complete explanation see wikipedia. ...Read more
Is the direct Coombs test done at birth testing the baby or the mother? Whose Coombs is being tested?
If mother is o positive and baby is a or b postive, how many will test postive for direct Coombs at birth? My Son did but didn't have jaundice.
Not automatic: If there are minor blood type incompatibilities, like ABO, not every doctor will test every baby with a direct Coombs. Some only test if the baby shows signs of early jaundice. So it's very difficult to say the exact percentage who are positive because not every baby who fits the question is even tested, let alone keeping track of how many are positive. Being + doesn't equal jaundice as you've seen ...Read more
Got slightly high porphyrin and Dr wants direct coombs, what is he trying to find? He hasn't explained what may be wrong
Baby is also Rh-: Your baby will also be rh-. Because rh- is recessive to rh+ you and your boyfriend both have two rh- genes. Your haplotype is rh-/rh- and your phenotype rh- and so is his. You and he can only give rh- genes to your babies. All of your babies with this father will be rh-/rh-. Don't sweat it. ...Read more
Red cell antibodies: Coombs serum is an antibody directed against other antibodies that makes antibody-coated red cells stick together. The direct Coombs test seeks antibodies on a patient's own red cells that may be causing red cell damage and perhaps anemia. The indirect Coombs test is used in blood banking to determine what antigens are present on unknown red cells by seeing what antibodies they bind. ...Read more
Let me explain: The direct Coombs test is used to test for autoimmune hemolytic anemia; ie, a condition of a low count of red blood cells (aka rbcs) caused by immune system lysis or breaking of rbc membranes causing rbc destruction. Follow hematologist direction for the treatment and precautions. ...Read more
Crohn's disease, I think I've found the cause. Would a Coombs test tell if a too strong immune system is the problem. There's obviously more to it.?
I am b - hubby is o +. I am not pregnant but before pregnancy can I get the indirect Coombs test done to check if my blood is sensitized?
Ask OB/Gyn: Easier and safer to get Rhogam shot to provide passive protection to fetus, if are or might become sensitized to (+) due to any peri-placental sharing. ...Read more
I`m pregnant, have rh-positive blood type and Coombs test is positive. It`s my second pregnancy, in first I had negative coombs. Will my baby be ok?
Newborn had positive Coombs test - I'm O positive and he's B positive. He didn't develop jaundice. How common is a positive Coombs test in newborns?
Common.: About 1 out of 3 pregnancies where the mother and child are ABO incompatible will be Coombs positive, but actual hemolytic disease of the newborn is rare. Only IgG type anti-A or anti-B cross the placenta, which most people don't express. Second the A and or B antigen is not heavily expressed on fetal cells. Also other cells besides RBCs express A and or B and "soak up" the antibodies. ...Read more
Would it be possible for a body to have adjusted to autoimmune hemolytic anemia over time. I have had fatigue, low grade fevers, positive coombs test, and an alarming drop in blood levels after surgery not losing much. Labs come back low normal.
Worth knowing: Let's finish your workup. Plenty of folks are Coombs-positive but not hemolyzing. If your reticulocyte count is up and you're well-nourished and aren't iron-deficient and it's been a while since surgery, maybe you're hemolyzing -- a reticulocyte count will tell you. With Coombs-pos, fatigue, low-grade fever, get tested for lupus. Your physician needs these missing pieces. ...Read more
Son was Coombs postive at birth from tested blood in umbilical cord. I'm O postive and he's b postive. Is this why he was Coombs postive?
Am 16weeks pregnant and I tested coombs Indirect positive. Can it affect the baby or makes the baby abnormal?
It refers to blood: You have red blood in you as does your husband. On the outside of the cells there are sugar molecules- either A or B or neither. Each of you will contribute the genes so the infant will get one from you and one from him and have either type A or type B or type AB or type O (neither). There is another Rh system. The Coombs refers to antibodies that you have against blood cells. Disc with your OB ...Read more
Multifactoral: Coombs (-) hemolytic anemia means that you have evidence of hemolysis (RBC fragmentation) that is not immune mediated. Potential causes include medications, artificial valves, microangiopathic causes, and disorders involving the RBC membrane, etc. Large granular lymphocytosis may be reactive or represent a leukemia if absolute levels are 2-20, 000 and sustained for >6 mo in your peripheral blood. ...Read more
Sure: The Coombs test (named for a Professor Robin Coombs, a British immunologist) looks for certain types of antibodies floating in the serum or attached to one's red blood cells. The antibodies can be related to "minor blood types" instead of the major ABO/Rh blood groups. If so, all three people can be A+ blood type, and still have a positive Coombs test in the baby. ...Read more
Am 16weeks pregnant and this is my second pregnancy. I tested coombs Indirect positive. Can it affect the baby or makes the baby abnormal?
Which antibody?: It sounds like you are referring to an antibody screening test which is done on all pregnant women. Some antibodies are significant during pregnancy, some only matter if you are receiving blood during a transfusion and others do not matter at all. Ask your doctor to go over your specific test result and explain the clinical significance ...Read more
Could slow onset autoimmune hemolytic anemia potentially go undisguised for a long time? Over a year of FUO, fatigue, pale, low normal labs, coombs +, warm antibodies. Transfusion needed after 400 ml loss in surgery. (hgb was 6, Hct 19%) no answers.
No answers: Is sometimes the case with FUO, the longer it stays the less likely an answer is found. It is mainly due to infections, auto-immune disorders or malignancy, but for one year any of those would have been discovered. You don't seem to have auto-immune hemolytic anemia though, at any rate I trust that your treating doctors explored all the possibilities to reach a diagnosis, trust them, the Dx is FUO ...Read more
Drug tests: Govt ones are much more sensitive and specific. ...Read more
The pt and PTT labs measure components of the blood clotting cascade. Abnormalities of one or the other or both lead towards the type of clotting abnormality (extrinsic or intrinsic pathway abnormality).
Inr is the international normalized ratio, a derived number based on pt to normalize a variation done in different labs or with different testing systems. It is used in patients on coumadin (warfarin). ...Read more
Penta and Panorama: They are both good tests. The panorama provides personalized risk scores for aneuploidy at 13, 18, 21, x, y and triploidy with the highest combined accuracy in published clinical trials among non-invasive prenatal tests currently available. The penta is a prenatal risk assessment for neural tube defects (ntd), down syndrome, and trisomy 18. ...Read more
Stress or angiogram:
Thallium test is another term for a nuclear stress test, which is a NONINVASIVE test to evaluate for any areas of heart muscle which look to be having reduced blood flow.
Angiography (Coronary angiogram, left heart catheterization, LHC, "cath") is an INVASIVE method to directly evaluate coronary arteries for blockages/narrowing. If narrowing is found, then angioplasty/stent placement may be needed ...Read more
Stress test: They are two different medications and have different cardiac effects for the purpose of stress test. While Dobutamine increases the heart rate and simulates exercise like state of the heart, lexis can works differently, primarily causing heart vessels to dilate and gives assessment of perfusion in heart. Both provide similar end information. ...Read more
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