Doctor insights on:
Rosiglitazone And Glimepiride Medication
Rosiglitazone is a thiazolidinedione, a class of diabetic medication that acts as a Insulin sensitizer by binding to the ppar receptors of the fat cells. The trade name is avandia (rosiglitazone). As a class effect of the medication, it can cause fluid retention and leads to worsening ...Read more
Combination drug: Of Avandia (rosiglitazone) and a sulfonylurea 2 drugs for diabetes avandia now severly restricted by fda- should be removed from market- had increased adverse cardiovascular outcomes sulfonylureas , as a separate pill, are still on market, but have high risk of low blood sugar and weight gain, so we avopid using them much better meds available. ...Read more
What to do if I have no idea what avandaryl (rosiglitazone and glimepiride) does, but I need something to make me go to sleep so I popped three, what does it do?
Who gave it to you?: "Popping" three pills whose effect you do not know is generally a bad idea. Avandaryl (rosiglitazone and glimepiride) is a medicine for DIABETES. It has nothing to do with sleep. It causes a drop in your blood sugar. If this happens when you are asleep, you could be in real trouble (i.e., permanent brain damage). In this case, what you would get is not sleep, but a coma. ...Read more
I am a type 2 diabetic and am taking avandia (rosiglitazone) and amaryl can they make you gain weight as a side effect?
Avandia (rosiglitazone) and Amaryl: Avandia (rosiglitazone) can cause fluid retention, however, Insulin levels in type 2 diabetics is usally high. The sulfonoureas like ameryl, increase the level of insulin. This causes weight gain. All drugs of this class carry an fda black box warning on increased mortality and morbidity. Metformin is the first drug that should be tried. Period. ...Read more
Thiazolindinedione: Rosiglitazone is a thiazolidinedione, a class of diabetic medication that acts as a Insulin sensitizer by binding to the ppar receptors of the fat cells. The trade name is avandia (rosiglitazone). As a class effect of the medication, it can cause fluid retention and leads to worsening of congestive heart failure. ...Read moreSee 1 more doctor answer
Same family: Hi. Glyburide is a second generation sulfonylurea and glimepiride is a 3rd generation. They work at the same receptors on the beta cell (the pancreatic cells that make insulin) and stimulate insulin release. Glimepiride is preferable because of less metabolite build up in kidney disease, but they're VERY similar. I never use them. In my opinion, based on good science, we have much better drugs. ...Read more
Diabetes: Either glyburide or glimepiride can be prescribed for management of diabetes. There may be a cost difference in your favor or you doctor may have a good reason to prescribe one or the other. More important - you need to take control of your eating habits, your weight (if overweight), and your exercise. Also please remember to measure your blood sugar regularly. Your doctor will advise you on dose ...Read more
Similar mechanisms: Hi. Glyburide & glimepiride (& glipizide & others in the sulfonylurea class, for that matter) all work by the same mechanism to stimulate endogenous insulin release. They differ in duration of action, metabolites, accumulation in kidney disease, etc. They're archaic drugs that I never use anymore. There are much better type 2 drugs out there. Their one benefit - they're cheap. ...Read more
Rosilitazone: I have to have a special license to continue to give it from a central pharmacy. I have only 1 patient still taking it. ...Read more
Causes heart problem: Avandia (rosiglitazone) is a type of oral medication used to lower blood sugar in type 2 diabetes, however in large studies patients taking Avandia (rosiglitazone) had an increased risk of heart attack and heart failure compared to other diabetes drugs, therefore it is only to be used by patients who can't take other anti diabetes medications. Excercise and keeping weight normal is extremely important to decrease need for drugs. ...Read more
I use 4 mg amaryl (glimepiride) morn and night, added 100 mg invokana, sugar 150-165 at night, can I increase either drug, 61 yr male, 189 lbs, a runner.
Yes: Invokana can be increased up to 300mg/day in patients that tolerate the drug. It appears that you are already at the max daily dose of amaryl, (glimepiride) and likely wouldn't add an additional benefit to increase the dose. You should talk with your doctor before increasing any drug. ...Read moreSee 1 more doctor answer
No, but same class: Both are 2nd generation sulfonylurea drugs for treatment of Type 2 Diabetes. According to a review by the Utah gov't, they conclude: "Overall ranges of HbA1c reduction seen w/glimepiride, glipizide & glyburide treatment in current literature are similar & choice of antidiabetes therapy should be based on individual patient characteristics, including: efficacy, cost, (see below) ...Read moreSee 1 more doctor answer
Not known for sure.: Some evidence from medical studies suggests that patients who take this medication have higher rates of heart disease and heart failure. This evidence is by no means complete, but it has led to the fda to limit strictly how this medication is prescribed. If your doctor is willing to prescribe the medication and you are doing well with it, it can be continued after careful consideration. ...Read moreSee 1 more doctor answer