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Doctor insights on: Rnp Smith Antibody

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Got my test results online.Says ANA speckled is at 1250. And other antibodies are found like ssa, ssb, rnp, smith, but are low levels. This mean SLE?

Got my test results online.Says ANA speckled is at 1250. And other antibodies are found like ssa, ssb, rnp, smith, but are low levels. This mean SLE?

Not necesarily: While these tests point to a probability of a collagen vascular disease, this could be lupus, mixed connective tissue disease, etc. The doctor ordering these tests knows your history and physical examination findings and should be the one interpreting these tests. Should be a Rheumatologist. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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What is the definition or description of: rnp antibody?

What is the definition or description of: rnp antibody?

Anti-RNP: http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357.

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Does it matter what the titre of rnp antibodies are when it is the only single one identified in diagnosing mixed connective tisseue disease?

Does it matter what the titre of rnp antibodies are when it is the only single one identified in diagnosing  mixed connective tisseue disease?

No: The diagnosis of mctd must first be made if the history and physical examination are indicative of a possible connective tissue disease. If those elements are present and the disease seems to overlap between conditions such as lupus and polymyositis and others, it is reasonable to do laboratory testing. Only then, if the rnp is above the reference lab normal, it will confirm mctd. Rnp alone: no dx. ...Read more

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What does a weakly positive ANA with only rnp antibodies indicate?

Specific to patient: The test by itself is not diagnostic.. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more

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Had lab test done. Sm/rnp antibody 2.5 pos. What does this mean?

Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place? ...Read more

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Can there be false positive rnp antibody tests even with a high titre of an ana?

FALSE POSITIVE RNP: It is possible we need to know what your symptoms and signs are, and why the tests have been ordered.The lab test apways have to be interpreted along with complete clinacal findings if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive.That in all probabilities is positive and not false positive. ...Read more

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I had a ANA test done everything came back good beside rnp antibodies. Value 1.8 reference range 0.0-0.9. Everything else was good is this bad.

It is barely positiv: So results must be interpreted very carefully with all clinical symptoms taken into account. A test by itself is just a test. You might need a good rheumatologist ...Read more

Dr. Suzanne Galli
76 doctors shared insights

Rnp Antibody (Definition)

http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357. ...Read more