Doctor insights on:
If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)
? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more
Explain my ANA?
dsDNA Ab "1"
ENA RNP Ab <0.2
ENA SM Ab Ser-aCnc <0.2
Scleroderma SCL-70 <0.2
all others <0.2 aswell.
dr sending me to rheumatologist.
Ask rheum: Your rheumatologist will be able to tell you much more after examining you. I am glad you are heading to the right specialist. ...Read more
May be: Why were these tests done? You must have had some symptoms for your doctor to order these tests. Negative results on blood tests are not an assurance that there is no disease. Please follow your doctor's advice for follow-up care. ...Read more
2.5yrs ago rnp was 1.0, now 1.7. U1-rnp neg. And all other ENA results. No clinic symptoms. Why is rnp raising?
See below: There is no clinical value in measuring how much a rnp level goes up or down. In the last two years, I have seen a large number of these to be false positives. That maybe the case with your values. Talk to your doctor about his or her interpretation. If you have not seen a rheumatologist, you should see one. ...Read more
I have no clinic symtoms, all ENA panel results 0.2, ana1:80, u1rnp 0.2 but rnp/sm 1.6. Why is rnp gone from 1.0 to 1.6 in past 3yrs? Something onset?
results unimpressive: These autoantibody results are all essentially negative. I doubt they have any clinical significance. ...Read more
I have no clinic symtoms, why is rnp 1.6, u1rnp 0.2 and all other ENA panel results 0.2. Is mctd onset?
not yet: It is impossible to make a clinical diagnosis based only on a lab result. If no symptoms present need only to follow over time and see if anything develops. Wait and watch and treat only if symptoms develop. ...Read more
Rnp raised from 1.0 to 1.6 in 2.5 years. U1rnp>0.2 all the time, all ENA panel results >0.2. No clinic symp. Why is rnp raising? Is mcdt onset?
Not important: I answered this question before. Neither rnp result is significant and this test has no clinical meaning with values this low. You do not have mctd. ...Read more
No clinic symptoms.Ena results all 0.2. Rnp/sm rising from1.0 to 1.6 in 3yrs.I'm afraid of progress. Doctors say no big deal, but why raising than?
Stop worrying: I am going to assume that your rnp/smith are below the ranges that the lab considers significant. All immunoassays turn up some positivity because the of cross-reactivity of other antibodies that you may develop from meeting different micro-organisms or goodness-knows-how. The miniscule rise in activity means nothing, your physicians were right to say thing ; if you had mctd you'd know u r sick. ...Read more
I have raised rnp and u1rnp is 0.2. Other ena's are 0.2 ANA 1:80. What is the difference between rnp and u1rnp? What does each one of them stand for?
essentially equivale: Essentially equivalent. U1 rnp is a component of rnp. Neither by itself is diagnostic. ...Read more