Doctor insights on:
Rnp Antibody Positive
If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)
? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus. All this needs to be correlated by your doc/specialist ...Read more
Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!
Lab numbers: These numbers don't show changes at joints and with most auto immune disorders, you may have periods of pain and increased lab numbers, usually related to stress in your life, and once treated medically or with stress reduction, pain/lab should improve. May want xray of one of involved joints just inflamed which can return to baseline. ...Read more
I'm having negative DNA, Sm and Rnp antibodies, but positive sm/rnp antibody, and high ANA titre speckled, so what is the diagnosis?
Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more
Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?
Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more
FALSE POSITIVE RNP:
It is possible
we need to know what your symptoms and signs are, and why the tests have been ordered. The lab test apways have to be interpreted along with complete clinacal findings
if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive. That in all probabilities is positive and not false positive. ...Read more
I had the following test results- what do they mean? Rfactor -7, ANA choice screen - positive, rnp antibody- 2.0, DNA da antibody 5
Depends: In absence of clinical symptoms, probably nothing. Clinical evaluation should provide clarity. ...Read more
I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9 and anachoice screen-positive...What lies ahead for me?
Diagnosis?: Connective tissue diseases can only be diagnosed if a person has symptoms and physical signs of a disease. Mctd cannot be diagnosed by blood test alone as a percent of the normal population has a positive rnp without any disease. It is not like checking your blood type (a positive, o negative, etc.). Ask your doctor how the diagnosis of mctd was made. ...Read more
What could a negative ANA and positive RNP antibodies mean? I have a history of chronic rheumatological symptoms, but my dr is not convinced its MCTD.
Lab problem: The ANA screening test is fraught with pitfalls, and if you have a way-high titer of U1-RNP on the tube test and symptoms / signs of mixed connective tissue disease (which is a rough thing) but ANA is negative, perhaps there's a problem with the substrate. Your physician will want to call the lab's pathologist -- he / she would be interested in knowing. Best wishes. ...Read more
My lab tests came back with a positive ANA and a positive rnp antibodies...Is this considered abnormal readings?
Yes: You need to see a rheumatogist.Get a more detailed answer ›
Rheumatology evaluat: It could be an overlap syndrome but you need a full of evaluation ...Read more
I was just diagnosd with mctd rnp antibody of 1.9 and anachoice screen-positive the only symptom is joint pain in my hand/wrist (i do have carpal tnl?
Positive Labs: Positive labs are meaningless unless you have symptoms. At this point, your doctor is aware of the positive results and will likely follow your symptoms. The positive simply means you are at a greater chance of developing symptoms though not everybody does. ...Read more
Anti-RNP: Http://www. Mayomedicallaboratories. Com/test-catalog/clinical+and+interpretive/81357.Get a more detailed answer ›
Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place? ...Read more
After sore throat, blood panel revealed infection and possible mono. Only other off number was rnp antibody of 5.8. Ana of 5. Could mono cause uprnp?
No.: Your serologies suggest mctd, or mixed connective tissue disease. This is much milder than systemic lupus erythematosis, and in 28 years, I have never had a dire situation with any patient with this DX alone. There is no relationship with mononucleosus. Most patients are treated with hydroxycholorquine or low dose prednisone. Aches and pains: aleve! Don't worry about it! ...Read more
Specific to patient: The test by itself is not diagnostic. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more
I have been reading online and have read that when the rnp is the only antibody that is positive that this indicated mixed connective tissue disease?
Labs can confuse.:
The labs are just a fraction of what needed to get you better. Your history and physical exam will determine your treatment. Looking for which labs will delay and confuse. You need to develop a few paragraphs of all your issues and sit down with your doctor to put the pieces together.
Began a wellness program and add in magnesium and acupuncture. ...Read more
In my labs it shows a positive ANA and then the lab automatically checks for antibodies...The only one was a low positive rnp. What does that mean?
Not a great deal.: Positive anas can be "false" positive. On the other hand an rnp antibody is not false. This combination would indicate mixed connective tissue disease. That having been said, I have many patients with a low titer rnp positivity and no signs of disease. Mctd is rarely a disease with major serious issues as other dx. ...Read more
I recently tested positive for rnp antibodies. I have in the past tested positive for ana. My symptoms: rashes, weakness, pain. Your interpretatio?
DEPENDS: Could be mixed connective tissue disease which combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis). Additional testing for the muscle enzymes, rheumatoid factor, echocardiogram (pulmonary hypertension) and other extractable nuclear antigens may help differentiate. ...Read more
Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus? N
See below: SM antibodies are specific for systemic lupus and are often associated with anti-RNP antibodies. They are commoner in Blacks and Asians. It is not an indicator of severity or predictor of organ involvement, which requires careful history, physical and other tests, preferably in the hands of a certified rheumatologist. ...Read more
ANA w reflex positive A direct 5 ; RNP antibodies 3.2 H. All other labs normal/negative. Rheumatologist says it's nothing, should I worry?
Do you have any symptoms? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your results and your doctor's opinion appear to be in sync and you should not worry.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more
What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more
I have a weakly positive ANA which show rnp antibodies...I have an extremely slow motility. Swollen fingers. Red palms. Could this be mctd?
Positive RNP test: Mixed connective tissue disorder or mctd is an autoimmune disease, cousin to lupus and other diseases. Fatigue, joint swelling, sjogren syndrome, raynaud's phenomenon (spasm of arteries in fingers), are common findings. Blood tests show a positive ANA and often positive rnp antibodies. The diagnosis and treatment are usually carried out by a rheumatologist. ...Read more
I just had my autoimmune panel come back with ANA Direct positive abnormal and RNP antibodies 1.3, I also have hair loss, fatigue is it lupus?
Need more info:
There are eleven criteria that are evaluated for diagnosis of lupus and at least 4 of those need to be met. You may consult this site for more information on this topic:
http://lupusresearchinstitute. Org/lupus-facts/lupus-diagnosis ...Read more
I have positive ANA with positive anti-rnp antibodies 6.8. Extreme fatigue, joint pain, low grade fevers and profound weakness. Saw rheumatologist who said it was fibromyalgia and that positive RNP "means nothing." what are your thoughts?
Can mixed connective tissue disease be diagnosed with a positive ANA and positive rnp anitibodies?
Does it matter what the titre of rnp antibodies are when it is the only single one identified in diagnosing mixed connective tisseue disease?
No: The diagnosis of mctd must first be made if the history and physical examination are indicative of a possible connective tissue disease. If those elements are present and the disease seems to overlap between conditions such as lupus and polymyositis and others, it is reasonable to do laboratory testing. Only then, if the rnp is above the reference lab normal, it will confirm mctd. Rnp alone: no dx. ...Read more
I had a ANA test done everything came back good beside rnp antibodies. Value 1.8 reference range 0.0-0.9. Everything else was good is this bad.
It is barely positiv: So results must be interpreted very carefully with all clinical symptoms taken into account. A test by itself is just a test. You might need a good rheumatologist ...Read more
Ana 1:40 speckled rnp 1.1 all other antibodies negative and all other results normal. Would I have lung involement with these tests?
Very unlikely: I would consider both of those test to be negative. ...Read more
Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B, RNP and SM. Lupus?
Got my test results online. Says ANA speckled is at 1250. And other antibodies are found like ssa, ssb, rnp, smith, but are low levels. This mean SLE?
Not necesarily: While these tests point to a probability of a collagen vascular disease, this could be lupus, mixed connective tissue disease, etc. The doctor ordering these tests knows your history and physical examination findings and should be the one interpreting these tests. Should be a Rheumatologist. ...Read more
Two years ago I had a postive ana. Recently I had a comprehensive ANA panel done and by rnp antibodies were 4.4. Could this be sle or mctd?
It could be: Unfortunately, there are significant numbers of false positives and false negatives with these types of tests. Only with the guidance of a rheumatologist will you be able to get the right diagnosis. Good luck! ...Read more
Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa (ro), ssb (la), scl-70, centromere. Is this likely lupus or a different automimmune?
My rnp anti bodies was 1.8 and range the is 0.0-0.9. The rest of my ANA was neg. Besides anti centromere b was 0.2 range is 0.0-0.9. No mctd hopefuly?
ANAs are complex: ANA panels are complex and difficult to interpret. Clinal correlation with the results and the patterns of positivity and negativity are vital, as no ANA test is 100% sensitive or specific for any one entity. An assessment by a clinician who has experience with collagen vascular diseases in general may be helpful. ...Read more