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Doctor insights on: Rnp Antibodies Positive

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!

Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3.  All others neg.  Very scared!

Lab numbers: These numbers don't show changes at joints and with most auto immune disorders, you may have periods of pain and increased lab numbers, usually related to stress in your life, and once treated medically or with stress reduction, pain/lab should improve. May want xray of one of involved joints just inflamed which can return to baseline. ...Read more

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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

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Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

MCTD: Usually considered diagnostic if high RNP titer, and two or more of the following: Raynauds, myositis, synovitis and swollen fingers/hands. ...Read more

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Can there be false positive rnp antibody tests even with a high titre of an ana?

Can there be false positive rnp antibody tests even with a high titre of an ana?

FALSE POSITIVE RNP: It is possible we need to know what your symptoms and signs are, and why the tests have been ordered.The lab test apways have to be interpreted along with complete clinacal findings if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive.That in all probabilities is positive and not false positive. ...Read more

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What could a negative ANA and positive RNP antibodies mean? I have a history of chronic rheumatological symptoms, but my dr is not convinced its MCTD.

Lab problem: The ANA screening test is fraught with pitfalls, and if you have a way-high titer of U1-RNP on the tube test and symptoms / signs of mixed connective tissue disease (which is a rough thing) but ANA is negative, perhaps there's a problem with the substrate. Your physician will want to call the lab's pathologist -- he / she would be interested in knowing. Best wishes. ...Read more

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My lab tests came back with a positive ANA and positive rnp antibodies...Are these normal ?

No.: Positive anas can be "false" positive. On the other hand an rnp antibody is not false. This combination would indicate mixed connective tissue disease. That having been said, I have many patients with a low titer rnp positivity and no signs of disease. ...Read more

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What does a weakly positive ANA with only rnp antibodies indicate?

Specific to patient: The test by itself is not diagnostic.. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more

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I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9 and anachoice screen-positive...What lies ahead for me?

I was just diagnosd with mctd...No symptoms just rnp antibody of 1.9  and anachoice screen-positive...What lies ahead for me?

Diagnosis?: Connective tissue diseases can only be diagnosed if a person has symptoms and physical signs of a disease. Mctd cannot be diagnosed by blood test alone as a percent of the normal population has a positive rnp without any disease. It is not like checking your blood type (a positive, o negative, etc.). Ask your doctor how the diagnosis of mctd was made. ...Read more

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I have been reading online and have read that when the rnp is the only antibody that is positive that this indicated mixed connective tissue disease?

I have been reading online and have read that when the rnp is the only antibody that is positive that this indicated mixed connective tissue disease?

Labs can confuse.: The labs are just a fraction of what needed to get you better. Your history and physical exam will determine your treatment. Looking for which labs will delay and confuse. You need to develop a few paragraphs of all your issues and sit down with your doctor to put the pieces together. Began a wellness program and add in magnesium and acupuncture. ...Read more

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In my labs it shows a positive ANA and then the lab automatically checks for antibodies...The only one was a low positive rnp..What does that mean?

Not a great deal.: Positive anas can be "false" positive. On the other hand an rnp antibody is not false. This combination would indicate mixed connective tissue disease. That having been said, I have many patients with a low titer rnp positivity and no signs of disease. Mctd is rarely a disease with major serious issues as other dx. ...Read more

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I recently tested positive for rnp antibodies. I have in the past tested positive for ana. My symptoms: rashes, weakness, pain. Your interpretatio?

I recently tested positive for rnp antibodies.  I have in the past tested positive for ana. My symptoms: rashes, weakness,  pain. Your interpretatio?

DEPENDS: Could be mixed connective tissue disease which combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis). Additional testing for the muscle enzymes, rheumatoid factor, echocardiogram (pulmonary hypertension) and other extractable nuclear antigens may help differentiate. ...Read more

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Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus?n

Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus?n

See below: SM antibodies are specific for systemic lupus and are often associated with anti-RNP antibodies. They are commoner in Blacks and Asians. It is not an indicator of severity or predictor of organ involvement, which requires careful history, physical and other tests, preferably in the hands of a certified rheumatologist. ...Read more

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ANA w reflex positive A direct 5 ; RNP antibodies 3.2 H. All other labs normal/negative. Rheumatologist says it's nothing, should I worry?

What for?: Do you have any symptoms? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your results and your doctor's opinion appear to be in sync and you should not worry. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex, if you have sex. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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I was just diagnosd with mctd rnp antibody of 1.9 and anachoice screen-positive the only symptom is joint pain in my hand/wrist (i do have carpal tnl?

I was just diagnosd with mctd rnp antibody of 1.9 and anachoice screen-positive the only symptom is joint pain in my hand/wrist (i do have carpal tnl?

Positive Labs: Positive labs are meaningless unless you have symptoms. At this point, your doctor is aware of the positive results and will likely follow your symptoms. The positive simply means you are at a greater chance of developing symptoms though not everybody does. ...Read more

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I have a weakly positive ANA which show rnp antibodies...I have an extremely slow motility..Swollen fingers..Red palms..Could this be mctd?

Could be: Depends upon your symptoms. Rheumatologic diagnoses are founded on a clinical syndrome supported by testing, not testing then hunting for symptoms. I suspect the doc who ordered these tests can explain them and how they relate to your condition. ...Read more

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Dr. Shari Jackson
80 doctors shared insights

Rnp Antibody (Definition)

http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357. ...Read more