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Used for lymphoma: Rituxan was one of the first monoclonals to be used to treat lymphoma having failed chemo. Rituxan which is a mAb targeting CD20, a marker on lymphomas and normal WBC induces ADCC tumor kill on all cells with the markers. Patients manage since the normal WBC's are regenerated in the marrow from precursor cells so count remains normal. Marked improvement in survival of lymphoma now seen. ...Read more
Mostly infusion rxns: Rituxan is given intravenously slowly at first to look for common immediate reactions like chills, fever, shakes, itching, hives, headache all of which could be prevented or lessened by giving premedications like Benadryl and steroids. Reactivation of hepatitis b, lowering resistance to infections, rapid destruction of tumor cells causing i'll effects to organs (tumor lysis) can also occur. ...Read more
Nhl grade 3a stage 1, 6 cycles of rchop-21 and igrt 30 gy taken. Is rituximab maintenace therapy required further?
Maintenance therapy: ...with rituximab is commonly given for follicular lymphoma, but not so much for other types of NHL (non-Hodgkins Lymphoma). Rituximab maintenance forestalls the the recurrence of the disease, but does not necessarily make patients live longer; because they could also wait and get rituximab a 2nd time when there disease relapses. ...Read moreSee 2 more doctor answers
TTP/rituximab: Twelve articles have reported 27 patients treated with Rituximab for ttp, with bene?t described in 25 (93%) of the patients. These observations from small uncontrolled case series is said to provide the background and rationale for a randomized clinical trial to establish the efficacy of Rituximab in this disease. ...Read moreSee 1 more doctor answer
Pemphigus vulgaris: Retuxan is used as first or 2nd line drug for pemphigus vulgaris. Steroid is used first but has side effects. Dapsone, sulfasalazine, pentoxiphylline photo therapy, ;, intravenous immunoglobin are also used for this blistery autoimmune disease. Retuxan+ivig has very good remission. Pls. See your dermatologist who has to look at your total picture with other diseases before prescription. Thanks. ...Read more
Median half life 32d: The median half life of Rituxan is 32 days. It takes approximately 5 half-lives before a drug is considered "gone" from the system. Therefore a median time-period would be 160 days from completion of treatment. Remember measurement of drug in the system is not the same as the side-effect of the drug or the length of time the lymphocyte population is affected. ...Read more
Most likely.: What side effects do you speak of? Most side effects of Rituximab occur during the infusion itself; I have very few folks complain of anything afterwards except maybe fatigue (that is if they receive Rituximab by itself). It does suppress the b lymphocytes for months but usually that translates into nothing. Patients who have had heart pain or irregular heartbeats in the past may experience .Reed. ...Read moreSee 1 more doctor answer
What SE?: What side effects (from rituximab)? About 25% of people will have an "infusion reaction" on initial dose with possible hives, shortness of breath, shaking, etc. That is usually not a condition that persists after the infusion is completed. Other side effects can come from killing cancer cells quickly such as tumor lysis syndrome, or some more rare long term Rituximab side effects? ...Read more
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