Doctor insights on:
Rituxan Rheumatisms Medication
Many patients: Rheumatoid arthritis can often be controlled with some of the newer medications including enbrel (etanercept). Many patients are saved from irreversible crippling of the joints. The key is to get early diagnosis and effective treatment to prevent worsening. Enbrel (etanercept) is a biologic response modifier meaning that the drug is made by a biological system. The drug can be very effective. Untreated RA has huge risks. ...Read moreSee 2 more doctor answers
Yes: Cellcept (mycophenolate mofetil) is an immunosuppressant drug used to treat a variety if conditions. In rheumatology it is most commonly used to treat certain types of lupus. Cellcept (mycophenolate mofetil) has been used successfully to treat dermatomyositis. It can help lower and or eliminate the steroid dose. ...Read more
MTX vs Humira (adalimumab): These drugs fight RA in completely different fashions. Mtx is the consensus first round choice of drugs to treat ra, both by the acr and eular (european version). Most, if not all, insurances require treatment failure with mtx before you start humira, (adalimumab) a much more expensive drug. In most cases, even if Humira (adalimumab) is started, patients will remain on mtx. ...Read more
Second line.: While Enbrel (etanercept) can be used alone, it works better in tandem with methotrexate. It is given by subcutaneous injection once per week, the dose being dependent on body size. It is also indicated for psoriatic arthritis and spondylitis. Most insurers want the patient to have been on lesser drugs. These would include incomplete response to mtx, sfz, and ho-q. It binds to tnf-alpha, which caues inflamm. ...Read moreSee 1 more doctor answer
Mainly Biologic DMAR: The biologic DMARDs are bioloigical disease modifying anti-rheumatic drugs. These type of DMARDS are effective in ankylosing spondykiitis (AS). The non biologic DMARDs in scientific studies have not shown much efficacy. You can discuss this with your physician. ...Read more
RA + psoriasis. MTX allergy. Enbrel (etanercept) non effective. Humira semi-effective but Vectra score 30 with extreme fatigue. MD wants to try Xeljanz?
RA + psoriasis: There are a number of newer medications that could help you. Xeljanz works by disrupting cytokine and growth factor signaling pathways. A trial of the medication is useful to see whether it helps you. Other medications that might help include Remicade (infliximab) and Apremilast ...Read more
Many patients!: Results are very good, particulary when used alone and better with methotrexate. The dirrence with Remicade (infliximab) is that it binds to tnf-a rendering ineffecftive. It is completely human in origin. A good choice for those who do prefer home sc injection, every two weeks. It is my favorite tnf-a class drug. ...Read more
Many patients!: Results are very good, particulary when used alone and better with methotrexate. The dirrence with Remicade (infliximab) is that it blocks the tnf-a receptor, rather than binding tnf-a itself, but it accomplishes the same thing. It's infusion intervals are longer, because the turnover of recptors is slower than the production of tnf-a itself. A good choice for those who do not want to inject themselves sc. ...Read more
See details: Both are often very effective.Get a more detailed answer ›
Early Ra. AntiCCP + 17. Other blood negative.
Doc1: MTX 7.5mg, Plaquenil 400mg, Celebrex (celecoxib).
Doc2: Plaquenil 200mg, Pred 5mg, Celebrex (celecoxib) .
Reasonable: You have the opportunity to do very well. Early RA responds better to any of the treatments compared to late RA (disease > 2 years). If you still have pain, stiffness, fatigue on this regimen, talk to your Rheumatologist about adding a biologic medication such as Enbrel, Humira or Remicade (infliximab). There are several others, but I usually start with one of these. Would help get rid of the prednisone. ...Read moreSee 1 more doctor answer
Mostly infusion rxns: Rituxan is given intravenously slowly at first to look for common immediate reactions like chills, fever, shakes, itching, hives, headache all of which could be prevented or lessened by giving premedications like Benadryl (diphenhydramine) and steroids. Reactivation of hepatitis b, lowering resistance to infections, rapid destruction of tumor cells causing i'll effects to organs (tumor lysis) can also occur. ...Read more
Ongoing polymyositis treatment @5mg prednisone&500mg sulfasalazine/day&17.5mg methotrexate/wk...What are appropriate jo1, wbc, abs mono, etc results?
Speak to your MD: With all due respect, your best place for this source of information is the physician providing your care, who knows you as a patient, your medical condition, and any other factors that may influence your treatment and results. This type of forum is best suited for general information on a topic, but not advice on specific care of a complicated problem. ...Read moreSee 1 more doctor answer
It's u as much as Rx: Again, this is a question for the treating specialist, most likely a rheumatologist. When treating a disorder like ra, there are a variety of medications that have been effective; as with everything else in medicine, no one size fits all, and the right drug or combo for each must be assessed over time by a specialist. ...Read moreSee 1 more doctor answer
Rheumatoid arthritis for 7 yrs. On methotrexate & prednisone. Tried so many drugs (orencia, enbrel, (etanercept) humira...). Feeling defeated. What else can I try?
Other choices: Some older drugs such as Plaquenil may help, especially with fatigue. There are also newer drugs that act via different mechanisms such as actemra (tocilizumab). I assume the diagnosis of RA is definite. If not, retest other possibilities. An exercise program may be very beneficial, especially if you start slowly and build up with hurting yourself. Don't give up hope. You can get better. ...Read moreSee 1 more doctor answer
Is plaquenil (hydroxychloroquine) with methotrexate without prednisone an effective treatment for moderate to severe rheumatoid arthritis ?
Yes: The combination is often a very effective treatment. ...Read more
It is magic?: 1the use of anti-malarials in autoimmune diseases was accidentally discovered in treating wwii vets for malaria. Those with RA improved. Chloroquine and ho-q were tested in sle, with very positive results. In the early 80's canadian researchers definitively showed fewer sle flares with ho-q. It is considered the rx of first choice for :sle. We now understand more of the mechanisms, but not all. ...Read more