Doctor insights on:
Rising Cea Levels Colon Cancer
Tumor markers: Cea is a tumor marker it does not occur with all colon cancers but the fact that it dropped so abruptly is a positive sign. The marker has the ability to be used to monitor for recurrence. This does by no means indicates you are done. There are a number of treatments for colon cancer and you should recruit the serviceces of a board certified medical oncologist for an opinion on tx options. ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Cea is rising as soon as started irinotecan for colon cancer. Primary already removed in march. Then found a liver met and node. Cea now 10.?
Disease progression: This does not necessarily mean that the chemotherapy is not working. You do need to be aware of the long-term outcome. My hope is that the patient will still get several more good years. If this is you, then you have a right to know the likely effects of whatever treatments you are offered. ...Read more
Since on chemotherapy, each month in a row CEA rising as: August 9.8 Oct 8 Dec 9 Jan 10 Colon cancer pt with a liver meta. Is this progression?
Not significant: It is very minute change. No significance. ...Read more
Colon cancer patient. Cea rising on irinotecan. It was started in oct when CEA was 8. Dec cea-9, jan CEA 10. Is this treatment failure?
Not necessarily: Chemotherapy can cause the CEA to rise when started. In addition, that is not a significant rise to make me concerned. Also, one wants to see a trend. Meaning, 8, 10, 15, 20 before one thinks failure. In addition, don't treat a number, treat what can be seen on the CT scan. Hope this helps. ...Read more
What do you suggest if my CEA test was a 3. should I do something else. I had colon cancer in 1997?
Chill: Three is normal, my friend. Colon cancer would be unlikely to relapse after 15 years plus. Of course, you could develop another colon cancer so you need to keep your follow ups with your oncologist and get your colonoscopies religiously. Live healthy and if you smoke, quit (that will increase the CEA, by the way). ...Read more
My brother is recovering from colon cancer of 2 years ago. His CEA count has gone from 5.2 to 9.7 to 19.8 in the last 6months. Is there a likelihood that cancer is back?
Back most likely: With a rise of the CEA level well above the normal level, the cancer is back or has spread to other organs or a new primary has formed. His physician/surgeon should immediately start a search for the tumor as some recurrences or new tumors can be removed or treated with chemotherapy. He will need studies such as a chest x-ray, ct of chest, abdomen. & pelvis, colonoscopy and possible pet scan. ...Read more
Depending how used: CEA first identified in 1965 by Phil Gold and Samuel O. Freedman in human colon cancer extracts. Thought to be valuable for dx colorectal Ca but the glycoprotein is also expressed in inflamed tissue so that smoking and enema can cause rise. Best used for monitoring so that if present in primary and rises it represents treatment failure and if diminishes during treatment it represents a response. ...Read more
No: The use of tumor markers has been approved for monitoring only. This holds true for the CEA's and Carbohyrate monoclonals such as Ca 19.9 and Ca 125. This is due to the fact that they are also affected by inflammatory changes as well as tumors arising in glandular tissue. If a dx of Ca is well established and the patient is treated with chemo, a drop in tumor marker level means response. ...Read more
Could use your help docs! My CEA test was a 3. Should I do something else? I had colon cancer in 1997?
First I would: Repeat the cea, if higher need to discuss with your oncologist or a colorectal surgeon or GI doctor to begin workup of recurrent colon cancer. Cea of 3 is not abnormal. You should have been getting colonoscopies regularly since your original diagnosis. Pet/ct scans may be necessary. But if CEA is 3 on repeat I would not be concerned. Just stay on 5year colonoscopy schedule. ...Read more
Can 1 drop in cea at round 2 of chemotherapy suggest anything. Drop from 65 to 55.? Metastic colon cancer pt
What can this mean. Before chemotherapy cea was 65, after 1 round 80 and after 2 round 55 for metastic colon cancer?
CEA: In general, rise in CEA in patients with metastatic colon cancer represents the disease progression. However, CEA surge phenomena was also described in patients who responded to the initial intensive chemotherapy. Immediate rise in CEA is usually not related to the disease progression. CEA surge is defined by >20% increase from its baseline. ...Read more
What can this cea pattern mean on chemotherapy for colon cancer mets 65 before chemo, 80 after round 1, 55 after round 2?
It's improving!: All it really means is the CEA is going in the right direction. .. falling after chemotherapy. You can not reliably speculate on what the number changes might say about the magnitude of improvement. There is too much individual variability and unpredictability for that. I would be pleased that these changes have occurred. Best wishes as you continue your treatment:) ...Read more
If cea has dropped after 2 round of chemotherapy from 80 to 55 is that a good drop? Or should it b more. Metastic colon cancer
Slight response: A tumor marker like CEA should only be employed for monitoring. During treatment if the tumor marker drops it is a suggestion that there is a response to treatment. If it rises then the tumor is probably progressing. This however should be confirmed by scan. A more significant finding however is not just a lowering of the marker level burt a return to normal. Chemo here should be continued. ...Read more
A CEA rise upon starting irinotecan in person with colon cancer suggest treatment not working? Cea was Oct 8, dec 9, jan 10.
Very good question!: The answer's somewhat debated. 1st, CEA levels even in the presence of cancer r somewhat variable, so my 1st question is *how much* did the values rise? An increase of 1 mcg/L may not b significant, though an increase of 100 mcg/L is definitely so. Also, levels increase if u r around cigarette smoke. Lastly, CEA could be released from cancer cells as they die. TTYD (Oncologist) to interpret numbrs ...Read more
Do these CEA readings mean chemotherapy not working in a colon cancer pt August 9.8, October 8, dec 9, jan 10. Met to the liver?
Stable: Ams an oncologist I would say those levels are stable. Follow your oncologist advice and do not stop chemo based on your CEA levels, they look good. ...Read more
In colon cancer patients, y do some hae higher cea"s (like in the 100, s) and some don't? My dad's CEA stands at 10 at present while on irinotecan
Change in level: Changes in the level of CEA are more useful for monitoring the course of disease than one reading. There is wide variation in CEA levels in patients with colon as well as other cancers. ...Read more
My mom had colon cancer nearly 12 years ago. Has been cancer free since surgery and chemo. CEA is now 3.7., highest it's been since then. Is this bad?
Not necessarily: When the colon cancer comes back, it usually comes back within the first 5 years from the diagnosis. It is unlikely that the colon cancer comes back after 12 years. In addition, CEA is not very sensitive nor specific for colon cancer. Other things like cigarette smoking, other liver problems etc can increase CEA. If she smokes, makes sure to encourage her to quit. She need to follow up with her MD ...Read more
My father had colon cancer 3 years ago and we fear it has returned and mets already. Tests are still being run but CEA was over 10. Is this a bad sign?
Likely to be: Cea or carcinoembryonic antigen, is a tumor marker usually associated with colon cancer, but can be seen elevated in other tumors. When associated with colon cancer, it is useful to follow serially after resection or to follow as part of treatment. If the value is normal at one point and becomes elevated, then a careful search for recurrence is indicated. ...Read more
Is a CEA lab result of a 4.4 a good indicator for stage 4 colon cancer that perhaps the cancer has not spread that much? Better survival rate?
No: Cea (carcinoembryonicantigen) is a protein that is released by some tumors into the bloodstream. It is useful for follow-up of cancer after treatment, ie, if the CEA is elevated before treatment and returns to normal after treatment, we are optimistic that the cancer was well-treated. If it then becomes elevated, we must search for recurrence. In your case, it is impt to know the # pre-rx. ...Read more
A friend has been told they have colon cancer, diagnosed via a tumour marker blood test, high cea, CT scan showed contained mass. Is this conclusive?
No, but...: But very suspicious for colon cancer. If your friend is similar in age to yourself a mass in the colon on ct scan is cancer until proven otherwise. And CEA levels can go up for other reasons but, given the mass, they would strongly favor cancer. But to answer your question "no"... They are not definitive. You would need a piece of the mass under a microscope to prove definitively its cancer. ...Read more
What is prognosis like for colon cancer pt with 1 liver met, 1 node and 0.5 lung nodule? Primary was resected last year. Cea 10. Bloodwork normal?
Prognosis: Prognosis is determined at time of diagnosis/treatment. Seems cancer is/was stage 4, which has a shorter prognosis than stage 1. If stage 4 is NEW, newly discovered liver metastasis, then prognosis will be negatively impacted compared to a year ago. Regardless of prognosis, talk with your docs. Take friend/family with you to appointments to help with understanding. Treatments exist. Be well. ...Read more
Not always reliable: I assume that from ALP you meant Alkaline Phosphatase (a type of liver function test). But avoid using abbreviations. This test can sometimes be correct in showing tumor progression but we need more information than this test alone in order to assess tumor response. The additional tests that help are measuring the liver size, checking CEA level (Blood test) and for making final decision, CT scan. ...Read more
Why do doctors recommend colonoscopy at age 50? People under 40 with no family history of colon cancer are getting sick and the number is rising.
My husband doing chemo after diagnosed with iiib colon cancer, tumor removed on #7 treatment, sugar level is really high now, what causes this?
I have low ferritian levels. The Dr told me that that can be a sign od colon cancer. I'm 31 years ago. Have heavy periods as well?
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