Doctor insights on:
Rickets Vs Brittle Bone Disease
A condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more
Probably: By c section.Get a more detailed answer ›
Usually: Osteogenesis imperfecta is a disorder of brittle bones. There is an abnormality in collagen 1 function, and so you are not able to make bones or other connective tissue structures correctly. This is why people often have "blue sclera" because the collagen is abnormal. Most cases are genetic, but a new mutation (not inherited) can be seen (about 35%). ...Read more
Should be done: Osteogenesis imperfecta is an abnormality in collagen 1 function, and so you are not able to make bones or other connective tissue structures correctly. This is why people often have "blue sclera" because the collagen is abnormal. Most cases are genetic, but a new mutation (not inherited) can be seen (about 35%). There are 8 major types, and these can be tested for. ...Read more
Severe cases evident: The more severe cases are evident before birth by ultrasound & or neonatal x-rays. Classification of lesser forms are based on age of first symptoms or specialized testing. My last case involved a skin biopsy and analysis of enzyme production in a specialty lab. Have your dr locate a genetics department at a med school or children's hospital if you want to pursue this testing. They can set it up. ...Read more
Osteoporosis: In the elderly (mainly) we refer to loss of bone structure as osteoporosis. Untreated hypothyroidism can lead to bad bone issues. Vitamin d deficiency and calcium defiency can lead to a problem called rickets which is associated with weakened bones, rare in the usa, but common in some developing countries. Other disorders can be listed as well. ...Read more
Typical brittle bone disease is due to loss of mineralization of normal bone and can be diagnosed by regular x-rays. It is uncommon in men, in which case other diseases and conditions may be suspected, such as malabsorption, or other systemic disease.
In women, it is common after menopause. ...Read more
Osteoporosis vs OI: Osteoporosis is when the bone becomes weak due to age and decreased calcium metabolism. The bone canal (central portion) becomes wide and thus the bone becomes weak. We usually see osteoporosis is postmenopausal women and older patients. Brittle bone disease is known as osteogenesis imperfecta and is a genetic disorder. ...Read more
Symptom relief: There is no cure since it is a genetic disease, but regular weight-bearing exercise to prevent bone loss, a diet rich in calcium and vitamin d, and sometimes even vitamin supplements will help. Bisphosphonates are a group of drungs that can increase bone density, but they have side effects. ...Read more
Genetic or not:
Brittle bone disease is an inherited disorder of bone that is called osteogenesis imperfecta.
Osteopenia and osteoporosis are disease of the bone where there is decrease density of the bone. This is associated with age, hormonal change, medications, smoking and other issues. Basically the bone cells are out of balance and take away more bone than they replace. ...Read more
Mesenchymal stem cells which can be isolated from bone marrow and other tissues are being infused into patients with osteogenesis imperfecta (oi) to see if they can cause normal bone growth.
Active clinical trial here:
http://clinicaltrials. Gov/ct2/show/nct01061099? Cond=%22osteogenesis+imperfecta%22;rank=1
more general info here:
http://ghr. Nlm. Nih. Gov/condition/osteogenesis-imperfecta. ...Read more
It is: A chronic disease.Get a more detailed answer ›
Look kind of like eds pictures so should I be getting tested for brittle bone disease or something?
Yes get diagnose: What type of the disease you have and take all the precaution for it. ...Read more
Not necessarily,: If kidney failure means on dialysis it is worse than if not on dialysis. At any rate need to control your phosphate levels and take your meds as prescribed to control you bone disease so no hip fracture will occur which will increase mortality. Control phosphate by no dairy products and control bean/ legume intake. Also, no cola including dr. Pepper, but root beer is okay. ...Read more
I don't recall ever having a patient with this specific condition whereas osteoporosis and osteopenia are far more common. I would need to know about the specific condition and the degree of bone fragility.
Smaller silicone implants may be recommended as a precaution. Alternatively fat transfer may be a good alternative to avoid I plants altogether if seeking a small augmentation. ...Read more
Hypermobile, poor healing, broken bones from cycle accidents. Need tests for brittle bone disease?
Yes: Osteogenesis imperfecta, or oi for short, is caused by genetic mutations of certain collagen genes. There are a number of types, and the severity can range from lethal shortly after birth to quite mild. Bone fractures, sometimes dental problems, and sometimes hearing loss can occur. The oi foundation is a great source of information: http://www. Oif. Org/site/pageserver. ...Read more
Read my answer:
So, oi has been noted in skeletons that date back to antiquity (egypt, specifically).
The disease is also known as lobstein disease. There were actually a few lobsteins, german-french surgeons and anatomists in the late 18th and 19th centuries.
The classification for oi is attributed to david sillence, an australian geneticist and an authority on the disease. ...Read more
Are the bones of individuals having osteogenesis imperfecta will become more brittle as they reach the age of 40 and above?
Deformities due to: Bones remain brittle and as you age there are deformities dure to repeated fractures, there are different kinds from type1 to type8. ...Read more
Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more
Typical brittle bone disease is due to loss of mineralization of normal bone and can be diagnosed by regular x-rays. It is uncommon in men, in which case other diseases and conditions may be suspected, such as malabsorption, or other systemic disease. In women, it ...Read more