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Doctor insights on: Rickets Vs Brittle Bone Disease

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Dr. Barbara Lavi
99 Doctors shared insights

Osteogenesis Imperfecta (Definition)

A condition causing extremely fragile bones. Osteogenesis imperfecta (OI) is a congenital disease, meaning it is present at birth. It is frequently caused by defect in the gene that produces type 1 collagen, an important building block of bone. There are many different defects that can affect this gene. The severity of OI depends on ...Read more


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Can brittle bone disease be fatal?

Can brittle bone disease be fatal?

Yes it could be: Some new born die during delivery because they have so many fractures during delivery. (osteogenesis imperfecta). ...Read more

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What is brittle bone disease called?

OI: Osteogenesis imperfecta. There are several types of the disease. Type 1 is mild disease. Type iii is the one in which people are most affected. Hope this helps. ...Read more

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Is brittle bone disease genetic?

Usually: Osteogenesis imperfecta is a disorder of brittle bones. There is an abnormality in collagen 1 function, and so you are not able to make bones or other connective tissue structures correctly. This is why people often have "blue sclera" because the collagen is abnormal. Most cases are genetic, but a new mutation (not inherited) can be seen (about 35%). ...Read more

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What is the treatment for brittle bone disease?

Symtomtic treatment: We have to treat people according the fractures they have. ...Read more

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Getting tested for brittle bone disease?

Getting tested for brittle bone disease?

Should be done: Osteogenesis imperfecta is an abnormality in collagen 1 function, and so you are not able to make bones or other connective tissue structures correctly. This is why people often have "blue sclera" because the collagen is abnormal. Most cases are genetic, but a new mutation (not inherited) can be seen (about 35%). There are 8 major types, and these can be tested for. ...Read more

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Will you grow out of brittle bone disease?

??: Not really sure what you mean
if it is osteogenesis imperfecta the answer is no
if it osteoporosis or it's lesser cousin osteopenia the answer is no
so looks like the answer is no. ...Read more

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Can I get my baby tested for brittle bone disease?

Can I get my baby tested for brittle bone disease?

Severe cases evident: The more severe cases are evident before birth by ultrasound & or neonatal x-rays. Classification of lesser forms are based on age of first symptoms or specialized testing. My last case involved a skin biopsy and analysis of enzyme production in a specialty lab. Have your dr locate a genetics department at a med school or children's hospital if you want to pursue this testing. They can set it up. ...Read more

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What is the medical name for brittle bone disease?

What is the medical name for brittle bone disease?

Osteoporosis: In the elderly (mainly) we refer to loss of bone structure as osteoporosis. Untreated hypothyroidism can lead to bad bone issues. Vitamin d deficiency and calcium defiency can lead to a problem called rickets which is associated with weakened bones, rare in the usa, but common in some developing countries. Other disorders can be listed as well. ...Read more

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How is one tested for brittle bone disease and what is it?

Osteogenesis OI: There are at least eight recognized forms of osteogenesis imperfecta,
check with your medical doctor he will guide though that for that. ...Read more

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Can it be possible for you to grow out of brittle bone disease?

Can it be possible for you to grow out of brittle bone disease?

Need specifics: The term brittle bones covers several disorders so you have to be specific. If you mean osteoporosis, it is treatable but you do not outgrow it. ...Read more

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What is the definition or description of: Brittle bone disease?

Osteoporosis: Typical brittle bone disease is due to loss of mineralization of normal bone and can be diagnosed by regular x-rays. It is uncommon in men, in which case other diseases and conditions may be suspected, such as malabsorption, or other systemic disease.
In women, it is common after menopause. ...Read more

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What's the difference between osteoperosis and brittle bone disease?

Osteoporosis vs OI: Osteoporosis is when the bone becomes weak due to age and decreased calcium metabolism. The bone canal (central portion) becomes wide and thus the bone becomes weak. We usually see osteoporosis is postmenopausal women and older patients. Brittle bone disease is known as osteogenesis imperfecta and is a genetic disorder. ...Read more

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Brittle bone disease. Advice any treatment?

Brittle bone disease. Advice any treatment?

Symptom relief: There is no cure since it is a genetic disease, but regular weight-bearing exercise to prevent bone loss, a diet rich in calcium and vitamin d, and sometimes even vitamin supplements will help. Bisphosphonates are a group of drungs that can increase bone density, but they have side effects. ...Read more

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How is one tested for brittle bone disease if pregnant?

Generally avoided: Testing for bone problems such as osteoporosis is generally not done in pregnancy because testing bone density involves radiation. Instead, we would recommend getting adequate calcium in your diet and exercise. ...Read more

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Osteopenia, osteoporosis or brittle bone disease--differences?

Genetic or not: Brittle bone disease is an inherited disorder of bone that is called osteogenesis imperfecta.

Osteopenia and osteoporosis are disease of the bone where there is decrease density of the bone. This is associated with age, hormonal change, medications, smoking and other issues. Basically the bone cells are out of balance and take away more bone than they replace. ...Read more

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Can you tell me how is brittle bone disease being treated with stem cells?

Can you tell me how is brittle bone disease being treated with stem cells?

Clinical trials: Mesenchymal stem cells which can be isolated from bone marrow and other tissues are being infused into patients with osteogenesis imperfecta (oi) to see if they can cause normal bone growth.
Active clinical trial here:
http://clinicaltrials. Gov/ct2/show/nct01061099? Cond=%22osteogenesis+imperfecta%22;rank=1
more general info here:
http://ghr. Nlm. Nih. Gov/condition/osteogenesis-imperfecta. ...Read more

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With brittle bone disease and kidney failure, is this fatal?

With brittle bone disease and kidney failure, is this fatal?

Not necessarily,: If kidney failure means on dialysis it is worse than if not on dialysis. At any rate need to control your phosphate levels and take your meds as prescribed to control you bone disease so no hip fracture will occur which will increase mortality. Control phosphate by no dairy products and control bean/ legume intake. Also, no cola including dr. Pepper, but root beer is okay. ...Read more

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Can you tell me about brittle bone disease had breast augmentation safely?

Unusual problem: I don't recall ever having a patient with this specific condition whereas osteoporosis and osteopenia are far more common. I would need to know about the specific condition and the degree of bone fragility.
Smaller silicone implants may be recommended as a precaution. Alternatively fat transfer may be a good alternative to avoid I plants altogether if seeking a small augmentation. ...Read more

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Hypermobile, poor healing, broken bones from cycle accidents. Need tests for brittle bone disease?

Hypermobile, poor healing, broken bones from cycle accidents. Need tests for brittle bone disease?

Collagen issue: Sounds more like a collagen issue. Unfortunately there not a treatment for poor collagen like there is for osteo-porosis. Still worth getting bone density, electrolytes, and hormones checked. (thyroid, para thyroid). ...Read more

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Is osteogenesis imperfecta a bone disease and disorder?

Is osteogenesis imperfecta a bone disease and disorder?

Yes: Osteogenesis imperfecta, or oi for short, is caused by genetic mutations of certain collagen genes. There are a number of types, and the severity can range from lethal shortly after birth to quite mild. Bone fractures, sometimes dental problems, and sometimes hearing loss can occur. The oi foundation is a great source of information: http://www. Oif. Org/site/pageserver. ...Read more

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Who was the person that discovered osteogenesis imperfecta (oi) or brittle bone disorder?

Read my answer: So, oi has been noted in skeletons that date back to antiquity (egypt, specifically).

The disease is also known as lobstein disease. There were actually a few lobsteins, german-french surgeons and anatomists in the late 18th and 19th centuries.

The classification for oi is attributed to david sillence, an australian geneticist and an authority on the disease. ...Read more

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Are the bones of individuals having osteogenesis imperfecta will become more brittle as they reach the age of 40 and above?

Deformities due to: Bones remain brittle and as you age there are deformities dure to repeated fractures, there are different kinds from type1 to type8. ...Read more

Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more


Dr. Linda DiMeglio
73 Doctors shared insights

Brittle Bone Disease (Definition)

Typical brittle bone disease is due to loss of mineralization of normal bone and can be diagnosed by regular x-rays. It is uncommon in men, in which case other diseases and conditions may be suspected, such as malabsorption, or other systemic disease. In women, it ...Read more