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Doctor insights on: Rh Induced Hemolytic Disease Of The Newborn

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Whats hemolytic disease of newborn?

Whats hemolytic disease of newborn?

Different blood type: Hemolytic disease of newborn is caused by different blood types in mom and baby. Classically, mom is rh negative (a- or o-, etc). The baby is rh positive. Mom then make rh antibodies that cross over to the baby and cause breakdown of the red blood cells. This can make the baby very sick. ...Read more

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Dr. Steven Griggs
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Neonatal (Definition)

The term neonatal is generally used to describe events that occur with an infant within the first 30 days after birth.Some practitioners are looser with the definition & extend the ...Read more


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How often is hemolytic disease of the newborn fatal?

How often is hemolytic disease of the newborn fatal?

Depends on form: Decades ago when i started rh hemolytic disease was often fatal during pregnancy & problamatic in newborns. Surviving infants often needed many exchange transfusions & had worrisome futures. Then a treatment called Rhogam came along & has ended that nightmare. In 26 yrs, I have transfused 1-2 ABO babies primarily for late stage anemia but had no fatalities. Rh disease is a problem without rx. ...Read more

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How can hemolytic disease of the newborn occur?

How can hemolytic disease of the newborn occur?

Antibodies: Mom has an antibody against an antigen that baby has on the red cells acquired from dad. The antibody crosses the placenta. Rhogam has done wonders to prevent antibodies against rh/d from causing the devastating illness that used to be common. ...Read more

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Does the possibility of an unborn baby getting antibodies c&d, (hemolytic disease of the newborn) increase with each pregnancy?

Does the possibility of an unborn baby getting antibodies c&d, (hemolytic disease of the newborn)  increase with each pregnancy?

HDN: With each pregnancy the mother increases her chances of developing antibodies which can in turn cross the placenta and harm the fetus. ...Read more

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Is there a genetic test for hemolytic disease of the newborn?

Yes: Hemolytic disease of the newborn, causing yellow skin and eyes (jaundice) with anemia, is most commonly due to a "set-up"--a blood type difference between mother and child. Blood types are caused by genes at the ABO and other loci (rhesus being most damaging), with o type or rh negative moms making antibodies to red blood cells of a or b or rh+ fetuses (if mom is o and fetus ab, baby switched), . ...Read more

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Are there any major complications to hemolytic disease of the newborn on the baby?

Yes: Hemolytic disease of the newborn can result in significant jaundice and/or anemia, either of which may require emergency medical intervention. Even when the jaundice subsides, the infant is at risk for anemia for the first several weeks of life. ...Read more

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What are the tests for hemolytic disease of newborn?

What are the tests for hemolytic disease of newborn?

Test for mom/baby: The baby will get test like coombs testing, hemoglobin or cbc, bilirubin tests and reticule yet counts. The coombs tests shows that an antibody is cause the hemolysis. The antibody specificity can be determined by additional tests. These antibody levels can be measured in mom and baby. Most of these antibodies will cause hemolysis. Some can cause decreased RBC production in the baby. ...Read more

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What are the symptoms associated with hemolytic disease of newborn?

Jaundice and anemia: Hemolytic disease of the newborn (hdn) may develop when a mother and her unborn baby have different blood types. The mother produces substances called antibodies that attack the developing baby's red blood cells. The most common form of hdn is ABO incompatibility, which is usually not very severe. The least common form is rh incompatibility, which can be very severe, but can be prevented. ...Read more

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Can symptoms of hemolytic disease of the newborn happen a week after birth?

Can symptoms of hemolytic disease of the newborn happen a week after birth?

HDN: The process of hemolytic disease of the newborn (HDN) starts soon after birth, however the symptoms (mainly jaundice) may not be detected if clinicians do not maintain a high index of suspicion. HDN due to Rh incompatibility is very rare in the US, but ABO incompatibility should be suspected whenever the mother has type O blood and the baby has either type A or B blood and there jaundice. ...Read more

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What is the treatment for hemolytic disease of newborn?

What is the treatment for hemolytic disease of newborn?

Various: Hemolytc disease can be mild and treated with bili lights. In extreme cases, it may be picked up early in pregnancy from an antibody screen. If positive, the antibody is identified. If a concerning antibodies present, the blood counts of the baby will be followed closely. Intrauterine transfusions may be required in these rare instances. ...Read more

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Is erythroblastosis fetalis is an example of autoimmunity or isoimmunity?

Alloimmunity: Autoimmunity is an immune response to one's own proteins while the example of Erythroblastosis fetalis is an immune response of mom's antibodies to a foreign antigen, this case from the fetus. ...Read more

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What is the most frequent transfusion associated disease complication of blood transfusion?

What is the most frequent transfusion associated disease complication of blood transfusion?

Bacterial in PLT: Transfusion is safer today than ever, but as any other intervention in medicine has risks associated with it. The infectious disease most commonly associated with transfusion is bacterial contamination in platelet components about 1 in 12, 000 transfusions. To put it in perspective HIV is about 1 in 2 million. The most common adverse event (1%) is fever and hives along with volume overload (taco). ...Read more

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Idiopathic autoimmune hemolytic anemia - what are the chances of dying?

Idiopathic autoimmune hemolytic anemia - what are the chances of dying?

Uncommon. : This would be very uncommon. But it can happen. Definitely take the prescribed medicine and follow up with your doctor regularly. ...Read more

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What is the result of neonatal screen positive in inherited metabolic disorders?

What is the result of neonatal screen positive in inherited metabolic disorders?

Depends: A screening test is a relatively simple & inexpensive test designed to narrow down the number of patients brought in for the more expensive specific tests. For every 10, 000 screened, 100 may show positive & secondary tests will show 2--3 with a real problem. The screen eliminated 99% that didn't need a specific test.The state notifies me of + screens & we get the tests.If a real pbm, rx is atarted. ...Read more

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What are symptom of hgb e/beta thal disease of an infant?

What are symptom of hgb e/beta thal disease of an infant?

HgbE beta thal: Your infant may be developing hypersplenism. See a pediatric hemotologist for help. ...Read more

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Which is the cause of polycythemia vera in infants of diabetic mothers?

Which is the cause of polycythemia vera in infants of diabetic mothers?

Polycythemia: Because blood sugar may be elevated in diabetic mothers, the blood cells become more viscous and can cause polycythemia in the newborn. Also if the cord isn't cut for three minutes, polycythemia may result. ...Read more

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Please tell me the dangers of hemolytic disease of the newborn (abo)?

Usually mild: Most of these kids have a brief issue with moderate elevations in bilirubin in the first first few days, but may face anemia days and weeks down the road.I remember a single ABO kid needing a transfusion at 6 weeks when this issue arose in 3 decades as a pediatrician. ...Read more

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Can you tell me the three classifications of hemolytic disease of the newborn?

Can you clarify?: The three most common blood group systems to cause hemolytic disease of the newborn are rh (usually d antigen, sometimes others), ABO (more common but less troublesome) and kell, though others can do it as well. Was this your question? If not, please write back. ...Read more

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What are the long-term health effects of blood group incompatibility (rh or ABO problems) post transfusion?

What are the long-term health effects of blood group incompatibility (rh or ABO problems) post transfusion?

Only Rh: If there is no immediate adverse reaction to ABO incompatible transfusion, there are no long term effects. For Rh mismatch, it could result in developing antibody to Rh that would cause transfusion reactions in the future if given Rh positive blood to a Rh negative person if s/he received Rh positive blood. It could also put the Rh positive fetus of the Rh negative woman at risk. ...Read more