Doctor insights on:
Repairing Myelin Sheath
Aids in conduction: Myelin sheath is a substance covering the peripheral nerves acting almost like the plastic you see covering a basic electrical wire. It offers not only protection to some degree but allows for a more rapid conduction of an impulse along the length of a nerve. The myelin also had tiny divits or nodes along its length that allow for the impulse to " jump" from node allowing for faster conduction. ...Read more
Myelin is a fatty tissue that surrounds nerve cells, in particular the nerve cell axon. This tissue is formed by other kinds of cells that support nerve cells called glial cells (schwann cells in the peripheral nervous system and glial cells in the brain and spinal cord. By insulating the nerves it helps the tiny electric signal that conducts impulses to travel quickly ...Read more
No definite: Unfortunately while axons are known to grow at an approximate rate of 1 mm/day, there is less known about myelin rates of growth. If you like research papers try searching online for "axon-glia interaction and membrane traffic in myelin formation" by robin white in frontiers in cellular neuroscience. It's technical but provides summary of what scientists are exploring now. ...Read more
Insulating sheath: Nerve sheaths are present to assist with nerve conduction. These are termed myelin sheathes. And are made from cells termed Schwann Cells. A tumour can grow from the nerve itself, or more commonly, from the surrounding Schwann Cells. The two most common forms of peripheral nerve tumours are called Schwannoma and Neurofibroma.. The more common Schwannoma and Neurofibroma are collectively referred to as Nerve Sheath Tumours. Most Nerve Sheath Tumours occur spontaneously. In some individuals, the Nerve Sheath Tumours may be part of a syndrome that predisposes to multiple nerve tumors. Such syndromes include neurofibromatosis and multiple schwannomatosis. In someinstances the Schwannoma converts to malignancy. ...Read more
Various mechanisms: The classic neurological diseases that involve myelin are Multiple Sclerosis, and Neuromyelitis Optica. Both Alzheimer's and Parkinson's involve nerve cell dysfnctn, and resultant neurotransmitter deficiencies. Some peripheral nerve disorders attack the central axon, and are termed axonal neuropathies. ...Read more
Is wearing away of myelin sheath what causes nerve damage? Can myelin sheath grow back to reverse damage? I have heard yes and no from doctors.
It's one cause: Demyelenating disease is just one cause of nerve damage that can occur over the course of a lifetime. Some scientists have found that the body can recruit the cells that make myelin to start making it again, but this process is very slow and incomplete. Researchers are working on finding ways to stimulate the repair of myelin and ways to protect myelin and the cells that make it from further damage ...Read more
It depends on how the myelin was injured. If myelin was severed/ traumatized axon only damage neuron will grow ideal conditions 1mm / month
Instead if disease process responsible for myelin damage (autoimmune disease i.e. MS, ALS,) this damage is permanent myelin sheath will not grow back damage is permanent. Peripheral diabetic Neuropathy if addressed before perm damag meylin can regenerate ...Read more
Why a build up of sulfatides in the white matter of the brain will cause the myelin sheath to deteriorate?
Complex: There are a series of lysosomal enzyme disorders, metachromatic leukodystrophy being one, which can be diagnosed by measurement of aryl sulfatase. Build up of any chemical imbalance especially presence of misfolded proteins, can interfere with normal cellular metabolism, and cause repair attempts to fail. Some of these disorders are associated with inflammation, and this too causes damage. ...Read more
Brain and marijuana: Ashtari et al have found adolescents and young adults who are heavy users of marijuana are more likely than non-users to have disrupted brain developmen and found abnormalities in areas of the brain that interconnect brain regions involved in memory, attention, decision-making, language and executive functioning skills. Myelin sheath are found in white matter circuits necessary for normal functio. ...Read more
Fatty tissue: Myelin is a fatty tissue that surrounds nerve cells, in particular the nerve cell axon. This tissue is formed by other kinds of cells that support nerve cells called glial cells (schwann cells in the peripheral nervous system and glial cells in the brain and spinal cord. By insulating the nerves it helps the tiny electric signal that conducts impulses to travel quickly down the nerve cells. ...Read more
Missing myelin. Right ring & pinky sluggish. Myelin won't grow back, but, taking piano lessons. Will diligent practice improve function, i.E. Pt?
Depends: Depends on the reason for the loss of myelin. Myelin can "grow" back but it depends on many factors that are disease specific. Practice usually helps especially if you have some strength left. ...Read more
When does the myelin in toddlers will mature? Is it true that nervous system (include myelin) will mature maximal at 2 years old?
I heard that immature myelin in toddlers can cause mild ankle clonus, is it true? When does the myelin will get mature?
Maturation: The nervous system matures from top down and inside to outside. Ankle clonus is normal in infants until they begin to walk, which the maturation allows. Persistence after 15-18 mo would be a problem. They first gain a wide grasp with fingers like pincers, but fine motor control of the individual fingers will not come in until well into school age. ...Read more
Given butter contains trans fat and cholesterol (good for myelin though), is it advisable to include (10g/day) in 1.5yo normal-weighing infant's diet?
Yes: Butter contains a small amount of trans fat in the form of conjugated linoleic acid, which is good for you! Not all trans fats are bad! Cholesterol in butter does not significantly raise our cholesterol levels and cholesterol is not the cause of heart disease. No need to avoid butter, but far better if organic esp. From grass-fed cows. See my comment for some interesting links. ...Read more
Please tell me, could a person with a myelin associated glycoprotein antibody, IgM have multiple sclerosis?
Possible comorbidity: The mag levels do not help confirm multiple sclerosis or even seem to correlate with this disorder, and typically, point toward problems with the peripheral nervous system. You could have ms and another condition, and a neurologist might help with both. Suggest you discuss your test and seek correlations if any. ...Read more
Can myelin injection treat MS, since the immune system is attacking myelin sheeth adding myelin in blood will keep WBC away from the nerves, right?
Wrong: This simply doesn't work. It's simplistic and in fact, you're asking for making the body more sensitive. Your body also makes attacking white cells to order when confortonted with something that it's sensitized to. Tolerization procedures exists for some autoimmune diseases and the whole are is fascinating. ...Read more
With peripheral neuropathy, what conditions could cause damage to both axons and myelin as shown in nerve conduction tests? And can it be reversed?
Brief explanation: Most neuropathies affect myelin coverings (Schwann cell), but an advancing axonal neuropathy can secondarily affect the myelin. This is not simple, and you would be far better served by a Concierge consult, and/or find an experienced Medical School neurologist. Reversibility depends on causes and appropriate therapy. ...Read more
Foot Drop: Most often is is the myelin sheath or insulation that is impacted. If the axons are effected it takes longer to recover if the causative reason is addressed. At about the 3 week mark after the occurrence it is easy to document the actual injury and extent with electrodiagnostic testing (ncs/emg). This would tell if demyelinating, axonal or combination of the two. This can help define prognosis. ...Read more
Burning pain, muscle spasms, back nerves inflamed. Neuro gave Pregabalin for 15 days. Suggested hiv related myelin problem. Will short pgn course help?
Depends on location: It sounds like what you have is a schwannoma attached to a nerve root coming from the cervical spine. These may very effectively be removed by a neurosurgeon. There certainly are potential side effects such as numbness or weakness in the distribution of the nerve that is attached to the tumor. ...Read more
In what kinds of neurons myelinated sheath is found and in which area of our body they are present?
As to nerve sheath tumors in thecal sac at l-4, in your experience do they typically grow or do they usually remain stable in size?
Can try applying: Topical verapamil (transdermal). If this does not help excision is always a possibility. ...Read more
Often by excision: Fibroma of tendon sheath is benign presenting as a small subcutaneous nodule slowly increasing in size. It may be seen in a multinodular growth pattern, composed of bland, spindle-shaped cells (myofibroblasts) in a dense, fibrous matrix. It nearly always arises in the distal portion of an extremity While benign, recurrence appears in up to 40% of case. Excision used to relieve symptoms but may be difficult due to adherence to tendon. ...Read more