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Doctor insights on: Relief After Enbrel Subcutaneous Injection

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Am starting a weekly injection of enbrel (etanercept) but very scared of side effects? Plz advise

Am starting a weekly injection of enbrel (etanercept) but very scared of side effects? Plz advise

See details: Enbrel (etanercept) is an incredibly effective therapy for several types of inflammatory arthritis. The risks are low with infection the most common one. The benefits far outweigh the risks as it prevents joint damage. Discuss your fears with your rheumatologist. ...Read more

Subcutaneous (Definition)

The hypodermis, also called the hypoderm, subcutaneous tissue, subcutis, or superficial fascia, is the lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome ...Read more


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Why do I need to rotate injection sites when I inject enbrel (etanercept)? Why can't I inject the same place?

Why do I need to rotate injection sites when I inject enbrel (etanercept)? Why can't I inject the same place?

Better rotate: Use at least two injection sites. You don't need to rotate between four sites. Rotating between sites gives the individual sites a chance to recover from the injections. That creates less pain and a lesser chance of a site reaction. ...Read more

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I take enbrel (etanercept) shots and a couple hours after i inject the shot i get a huge knot at the injection point and it itches for days is this normal?

I take enbrel (etanercept) shots and a couple hours after i inject the shot i get a huge knot at the injection point and it itches  for days is this normal?

Yes: Injection site reactions are one of enbrel's most common side effects. These are uncomfortable, but not serious in general. These may not occur after every injection. ...Read more

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7yr old on enbrel (etanercept) been having injection site reactions each time bigger than last. Last time 3.5inches long. At what point should she stop taking it?

7yr old on enbrel (etanercept) been having injection site reactions each time bigger than last. Last time 3.5inches long. At what point should she stop taking it?

Not dangerous: First, rest assured, the injection site reaction is not dangerous. There are several options: 1) try the prefilled syringe instead of injector. We see less redness and pain with this form. 2) ice the area immediately after the shot. This will decrease the reaction. 3) switch to alternate medication such as Humira (adalimumab). You should voice your concerns to your doc and discuss options ...Read more

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Child has injection site reactions on enbrel and vomits after getting shot even with Zofran (ondansetron) what would be a good alternative drug for JRA?

Child has injection site reactions on enbrel and vomits after getting shot even with Zofran (ondansetron) what would be a good alternative drug for JRA?

Other biologic.: The details of your child's history and past treatments are unknown, of course, but one could consider an alternative biologic. Each one is designed differently than others. I urge to set up a follow up with your child's pediatric rheumatologist to discuss further. Good luck and hope they feel better. ...Read more

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Recently diagnosed with psoriatic arthritis & prescribed enbrel (etanercept). How effective, in the long term, are these injections? Any downsides? Thank you!

Recently diagnosed with psoriatic arthritis & prescribed enbrel (etanercept).  How effective, in the long term, are these injections?  Any downsides?  Thank you!

Extremely effective: Tnf agents are extremely effective in the treatment of psoriatic arthritis. It is surprising that the side effects were not reviewed with you prior to starting the med. The major risk is infection with other possible side effects being reduced blood counts, liver inflammation, neurologic disorders and a possible increased risk of lymphoma. ...Read more

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Dear dr I have s a spondylitis ankylosis the anti tnf alpha enbrel (etanercept) 25 mg for 1year by injection every 2 weeks not effect with me can I do please help?

Dear dr I have s a spondylitis ankylosis  the anti tnf alpha enbrel (etanercept) 25 mg for 1year by injection every 2 weeks not effect with me can I do please help?

Enbrel (etanercept) dose too low: Your Enbrel (etanercept) dose is very low and may not be sufficient to help. The usual dose would be 50 mg weekly. Ask your doc about increasing the dose. ...Read more

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Hi, I have Ankylosing Spondylitis, and I am on a weekly injection of Enbrel (etanercept). I am wondering whether or not I may donate blood? Thank you!!

Hi, I have Ankylosing Spondylitis, and I am on a weekly injection of Enbrel (etanercept).   I am wondering whether or not I may donate blood?  Thank you!!

Better not: although you need to be commended for wanting to donate, but in your case it might affect your enbrel (etanercept) blood level, and better check as well with the blood bank you intend do donate to, they have a list of conditions that shouldn't donate blood, goodluck ...Read more

Dr. Robert Lowe
121 doctors shared insights

Etanercept (Definition)

Etanercept is an immune system suppressor which is a kind of ...Read more


Dr. Robert Lowe
140 doctors shared insights

Enbrel (Definition)

Enbrel is an immune system suppressor which is a kind of ...Read more