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Doctor insights on: Quetiapine Abilify Aripiprazole

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Is aripiprazole more potent than quetiapine as an add-on for MDD?

Is aripiprazole more potent than quetiapine as an add-on for MDD?

Depends on who u ask: I found a study done in Turkey in 2013 which found that patients treated with aripiprazole spent less time in their major depressive episode compared to those treated with quetiapine. Ref: ScienceDirect. Value in Health Regional Issues 2 (2013) 171-180. ...Read more

Dr. Heidi Fowler
433 Doctors shared insights

Quetiapine (Definition)

Quetiapine (brand seroquel) is classified as an atypical antipsychotic medication. It is fda approved to treat schizophrenia, bipolar disorder, and as an adjunct with antidepressants in the treatment of major depressive disorder. Serious side effects include tardive dyskinesia, neuroleptic malignant syndrome, and metabolic syndrome with weight gain, risk of ...Read more


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I want to know if the mechanism of action of these drugs is the same: quetiapine, ziprasidone and aripiprazole?

I want to know if the mechanism of action of these drugs is the same: quetiapine, ziprasidone and aripiprazole?

No: The mechanism of action differs in all 3 (aripiprazole, quetiapine & ziprasidone). .. However, the main therapeutic target for these is D2 (a type of Dopamine) so in that way they are all similar. How each of the drugs influences the other neurotransmitter systems is where the differences arise. Hope that helps! ...Read more

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I want to know the difference of mechanisms in this drugs: aripiprazole 15 mg, and quetiapine 5 mg (1/2 of pill). I have a bipolar disorder.

Close but not cigar: Independently of their dosages, they are both atypical antipsychotics. They share similar properties as antipsychotics and mood stabilizers. What's different is their side effect profile, life time, tolerance, etc. Seriquel is more edating and increases appetite. Abilify (aripiprazole) can be more activating, less weight gain. ...Read more

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I have bipolar disorder and psychiatrist prescribed me quetiapine. He says ziprasidone and aripiprazole "are not indicated in my case. Why?

I have bipolar disorder and psychiatrist prescribed me quetiapine. He says ziprasidone and aripiprazole "are not indicated in my case. Why?

Depends: Really depends on the symptoms that you're having. Personally, I have found ziprasidone difficult to prescribe because it needs to be taken with a meal & twice a day which most patients have difficulty adhering to. But this is really a matter of prescriber preference. Seroquel (quetiapine) is a great drug but has to be dosed properly - Hope that it helps! ...Read more

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I was putting too much weight on with quetiapine so I changed to Abilify (aripiprazole) to try and loose weight. But I am getting muscle spasms. Is that normal?

I was putting too much weight on with quetiapine so I changed to Abilify (aripiprazole) to try and loose weight. But I am getting muscle spasms. Is that normal?

Yes: These meds can cause a variety of side effects, temporary like muscle spasms, restlessness, akathisia, to permanent like diabetes, parkinsonism, to life threatening such as fever and muscle aches. ...Read more

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Which drug works best in most cases for bi polar? Olanzapine, isperidone, quetiapine, aripiprazole, lamectal?, and a new drug that begins with an "f"?

Which drug works best in most cases for bi polar? Olanzapine, isperidone, quetiapine, aripiprazole, lamectal?, and a new drug that begins with an "f"?

Bipolar: I think your "f" drug may be fanapt, or iloperidone. And maybe you meant "risperidone." all of these antipsychotics may be used in acute mania or psychotic depression, along with other mood stabilizers. But only asenapine, olanzapine, quetiapine, risperidone, ; ziprasidone have fda indication as monotherapy in acute mania or depression. Maintenance: Risperidone consta (and Olanzapine in ca). ...Read more

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Does seroquel and Abilify (aripiprazole) help?

Seroquel/Abilify: Depends on what symptoms they are treating! ...Read more

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Can it be possible for you to mix seroquel XR with abilify (aripiprazole)?

Yes but...: People tend to try to avoid combining medications in the same class, depending on what is being treated, the doses involved, and so on. These medications together can increase the risk of irregular heartbeat, sometimes dangerously. They can also be sedating, moreso together. It also depends what they are being used for and how. Ask your doctor. ...Read more

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Is there a difference in taking abilify (aripiprazole) and seroquel, one pill in the morning and another pill at night for both, between taking them as a single dose of 2 pills together all at night?

Yes!: These are in the same class but they are NOT interchangeable! You cannot safely pick the dose and timing of either. Work closely w/ the prescribing doctor who is exploring fairly new terrain to find the best way to help you. Don't do it alone - it can be very risky! ...Read more

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Is Abilify (aripiprazole) better than seroquel in terms of adverse effects? Also what is the likelihood of akathisia (my big worry)?

Is Abilify (aripiprazole) better than seroquel in terms of adverse effects? Also what is the likelihood of akathisia (my big worry)?

Each person's unique: Side effects can be different in different people and that's frustrating, but sometimes it cuts in your favor too. There's a piece right here on that question:
https://www. Healthtap. Com/#topics/akathisia-and-abilify
Read it and talk to your provider. Best! ...Read more

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Just started titration to Abilify (aripiprazole) from seroquel. The latter helps me sleep. Can both meds be taken or is there a reason my psych suggested titration?

Just started titration to Abilify (aripiprazole) from seroquel. The latter helps me sleep. Can both meds be taken or is there a reason my psych suggested titration?

Same class of med: These two are the same class of meds, and the risk of side effects with metabolic problems goes up if you are on both. It is fine to take both for a very short time as you switch one to another, but to stay on both long term would not give you any additional benefit to outweigh the risk of being on both. ...Read more

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Why can't a recovering alcoholic take Xanax but can take Abilify (aripiprazole) or seroquel?

Why can't a recovering alcoholic take Xanax but can take Abilify (aripiprazole) or seroquel?

Mirrors alcohol: Xanax's effect in the body mirrors and potentiates that of alcohol. Abilify and Seroquel do not. Though you shouldn't drink on those drugs either. ...Read more

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I take Abilify (aripiprazole) 5 mg, seroquel 50 mg and cymbalta 120 mg. Should I quit cold turkey, will my libido come back?

See below: Any decision concerning your medication, should be discussed with your prescribing provider. Good luck! ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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Abilify (aripiprazole) or seroquel xr? My doc is leaving it up to me. I'm adding it for mdd & also have insomnia. Which would you recommend? Weight gain is concern.

Dr. Alan Ali Dr. Ali
1 doctor agreed:

Abilify/Seroquel: Abilify (aripiprazole) is less likely to make u gain weight but is also less sedating in most cases. Seroquel is the opposite. However, at low dose, seroquel would be preferable if insomnia is major concern. ...Read more

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Could reason from insomnia be due to abilify (aripiprazole)? Only took 5 mg but. Three days later took Prozac with seroquel and read Prozac increases half life abili

Could reason from insomnia be due to abilify (aripiprazole)? Only took 5 mg but. Three days later took Prozac with seroquel and read Prozac increases half life abili

Yes: Prozac does increase the blood level of abilify (aripiprazole). Especially if you get restless legs you can develop insomnia. I have however seen people develop insomnia from Abilify (aripiprazole) even without having restlessness. Best wishes. ...Read more

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If seroquel or Abilify (aripiprazole) causes me an enlarged thyroid, will my doctor put me on another drug?

Up to you Doctor: It is unusual for those medications to cause thyroid problems. There is some thought that it may be a temporary problem eventually going back to normal. However, the option of treating the under active thyroid with thyroid hormone replacement may be a consideration for the physician if the seroquel and Abilify (aripiprazole) are the best options for the patient's underlying problem. ...Read more

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Am Bipolar 1, been suicidal, irritable and impatient, are these all signs of mania? Also hoping switch from Seroquel to Abilify (aripiprazole) will help? Any thoughts?

Am Bipolar 1, been suicidal, irritable and impatient, are these all signs of mania? Also hoping switch from Seroquel to Abilify (aripiprazole) will help? Any thoughts?

Can't say: Mixed? Manic? Depressed? Not enough info to know. Regarding which atypical to use - you won't really know until you have seen response to both. Abilify (aripiprazole) is now used to augment other meds for depression. ...Read more

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If seroquel and Abilify (aripiprazole) cause enlarged thyroid cancer will my doctor put me on another one?

If seroquel and Abilify (aripiprazole) cause enlarged thyroid cancer will my doctor put me on another one?

Not Cancer: It is unusual for those medications to cause an underactive thyroid. There is some thought that it may be a temporary problem eventually going back to normal. However, the option of treating the underactive thyroid with thyroid hormone replacement may be a consideration for the physician if these psych meds are the best options for the patient's initial problem. Thyroid cancer is different. ...Read more

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Is abilify associated with as much weight gain as zyprexa and Seroquel. And if so is it dose related?

Is abilify associated with as much weight gain as zyprexa and Seroquel. And if so is it dose related?

Wt gain: Each of these atypical antipsychotics are associated with cholesterol problems and weight gain. According to studies of populations of individuals, Zyprexa is associated with the most weight gain of the three, Seroquel is in the middle and Abilify is the least. Each person is different.

I've certainly seen significant (20 lbs+) weight gain from each of these agents. ...Read more

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I take Lexapro for ptsd used to take geodon, (ziprasidone) abilify, trazodone and seroquel what are other meds for ptsd?

I take Lexapro for ptsd used to take geodon, (ziprasidone) abilify, trazodone and seroquel what are other meds for ptsd?

Dr Jacobson is RIGHT: Minipress (prazosin) is a wonderful medication for nightmare control in some people where nothing else works. Quite a revolutionary step in some very bad and chronic cases for parasomnias (nighmares) in folks with PTSD. Ask your doctor about it if you suffer from this condition. ...Read more

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Zyprexa, seroquel, risperdal, Abilify all can have porential risk of raising blood sugar...Does latuda (lurasidone) carry this risk also. Not to familiar with it?

Zyprexa, seroquel, risperdal, Abilify all can have porential risk of raising blood sugar...Does latuda (lurasidone) carry this risk also. Not to familiar with it?

Latuda (lurasidone) Diabetes: Between five and 12% of patients studied on Latuda (lurasidone) developed blood sugar levels greater than 126 during the study period. A lot of this has to do with the various doses and it was not a linear increase with the doses studied. ...Read more

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I have been on seroquel geodon (ziprasidone) Abilify I could diet on geodon (ziprasidone) lose weight now on zyprexa are there non weight gain psychotics? Abilify didn't sedate me

I have been on seroquel geodon (ziprasidone) Abilify I could diet on geodon (ziprasidone) lose weight now on zyprexa are there non weight gain psychotics? Abilify didn't sedate me

A matter of degree: The newest agents in the antipsychotic class such as Vraylar, Saphris and Latuda are known for being closer to weight-neutral, though some amount of weight gain (a few pounds) is still observed in clinical trials even with these drugs. ...Read more

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I have dry mouth. Can medicine cause them when I stop taking them? Stopped geodon, (ziprasidone) zyprexa, abilify, seroquel? Still have dry mouth and tongue.

I have dry mouth. Can medicine cause them when I stop taking them? Stopped geodon, (ziprasidone) zyprexa, abilify, seroquel? Still have dry mouth and tongue.

Stay adequately: Hydrated and make sure your prescriber is aware. Please get tested for sjögren's syndrome which can cause chronic dry mouth. Dry mouth should not continue after the meds are stopped. Talk to your family doctor about treatments of dry mouth that are available, including Bethanechol and xyzal (levocetirizine). Best wishes. ...Read more

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Tried geodon, (ziprasidone) risperdal, abilify, haldol, seroquel, zyprexa and dislike all them. For paranoid schizophrenia. Don't like insomnia, akathisisa, weightga

Tried geodon, (ziprasidone) risperdal, abilify, haldol, seroquel, zyprexa and dislike all them. For paranoid schizophrenia. Don't like insomnia, akathisisa, weightga

Talk w/psychiatrist: You have not asked a question here, but have expressed your displeasure with some of the available antipsychotic medications for your illness. Please discuss this with your own psychiatrist, as there are still other options available. Paranoid schizophrenia is a serious illness and does need treatment. Best wishes. ...Read more

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Is aripiprazole a new drug?

Is aripiprazole a new drug?

Yes relatively: Abilify (aripiprazole) was approved in 2002. Fda indications include: schizophrenia, acute manic and mixed episodes associated with bipolar disorder; an adjunct for the treatment of major depressive disorder; to treat irritability in children with autism. It is a Dopamine receptor partial agonist, which makes it unique compared to prior medications (even relatively new ones) for schizophrenia. ...Read more

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How will aripiprazole help me?

How will aripiprazole help me?

It depends: It depends on why it is being prescribed. Please speak to your physician to best understand why he or she is prescribing the medication and how it may help you. ...Read more

Dr. Alan Ali
465 Doctors shared insights

Seroquel (Definition)

Seroquel is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more


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