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Doctor insights on: Pulmozyme Side Effects

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My sister makes herself throw up when she does her pulmozyme (dornase alfa). What can I do to help her?

My sister makes herself throw up when she does her pulmozyme (dornase alfa). What can I do to help her?

Mgt/CF: Some secretions can be swallowed and this can cause irritation of the stomach lining. She should speak with her PCP about the use of an antacid, following the Pulmozyme (dornase alfa) with nebulized saline to clear the secretions. Chest physiotherapy is an important part of her management. Does she wear a vest for CPT? A virtual consultation to review chest clearance and her medications can be booked online. ...Read more

Dr. Tanya Russo
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Dornase Alfa (Definition)

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Is it safe to take pulmozyme (dornase alfa) while pregnant or breastfeeding?

Is it safe to take pulmozyme (dornase alfa) while pregnant or breastfeeding?

Yes: Pulmozyme (dornase alfa) is a category b, deemed safe in pregnancy. Its safety in lactation is unreported, but should have minimal absorption, and i would consider the benefits vs risk for lactation on a case-by-case basis with my patients. ...Read more

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Could pulmozyme (dornase alfa) use result in increased respiratory rate in non-cf patient with a tracheostomy?

Could pulmozyme (dornase alfa) use result in increased respiratory rate in non-cf patient with a tracheostomy?

Maybe: Side effects with Pulmozyme (dornase alfa) are various and can include irritation of the throat, nose and voice changes. It can also cause hoarseness. I use a fair amount in my patients and have not seen it increase respiratory rate. I guess if it was irritating the airway you could breath faster due to pain/discomfort. I don't think that increased resp rate is very common on this drug. ...Read more

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Dr. Suzanne Galli
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Pulmozyme (Definition)

Pulmozyme ...Read more