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Doctor insights on: Prozac Make Pain Depression Worse

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Dr. Pamela Pappas
4,492 doctors shared insights

Depression (Definition)

Depression is a mood disorder that can affect behavior and emotions. Symptoms of depression include feeling down most of the time, losing interest in previously enjoyable activities, increase or decrease in appetite or weight, sleeping more or less, becoming easily agitated or lethargic, feeling worthless, feeling guilty, having difficulty concentrating, thinking more about death and dying. Depression can sometimes result in suicidal thoughts and plans. In this case, emergent ...Read more


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Could not taking my Prozac (fluoxetine) for 2 weeks cause my depression to become worse?

Yes: Although Prozac (fluoxetine) is metabolized very slowly in the body, missing multiple doses can lead to a relapse. Most serotonin drugs are not effective until they are taken for several weeks in a row. Please take all medications as prescribed. If you cannot tolerate a medication due to a side effect, consult your physician on how to stop it. ...Read more

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Is it true when starting Prozac (fluoxetine) that anxiety/depression can get worse before getting better?

Is it true when starting Prozac (fluoxetine) that anxiety/depression can get worse before getting better?

Yes: Unfortunately, it usually takes 2+ weeks for the good effects of antidepressants to start, while side-effects can happen right away. Prozac (fluoxetine) is a relatively activating or stimulating antidepressant. It can worsen anxiety, especially at first. (in fact, if anxiety was a major problem, i might choose a different ssri in the first place.) the prescribing doc should help with any side effects. ...Read more

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Been taking Prozac (fluoxetine) 10mg for 6 days for postpartum depression and feel worse, can this be possible?

Been taking Prozac (fluoxetine) 10mg for 6 days for postpartum depression and feel worse, can this be possible?

Yes: It is possible to feel worse before you get better. Tell your doctor. Medication takes time to work. Doses may need to be adjusted. If you do not tolerate one drug, another one may work. Remember, depression is treatable! ...Read more

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I've taken Prozac (fluoxetine) for 3 days and i feel my depression worse than ever. I have suicidal ideation, anhedonia. should i continue taking it?

I've taken Prozac (fluoxetine) for 3 days and i feel my depression worse than ever. I have suicidal ideation, anhedonia. should i continue taking it?

Please see doctor: Please see your doctor asap. Please realize medicines that help depression do not work the same as meds, for example, that treat infections. Our brains often take 3-6 weeks to heal from depression IF they are going to respond to the anti-depressant medication. It is not unusual to need med changes if there is no response or they are intolerable. Support and talk therapy are vital as a bridge! ...Read more

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Tapered from celexa 40mg to Prozac (fluoxetine) 40mg in a period of 2 months because of worse depression. Prozac (fluoxetine) is making me feel derealization. Should i stop it?

Tapered from celexa 40mg to Prozac (fluoxetine) 40mg in a period of 2 months because of worse depression. Prozac (fluoxetine) is making me feel derealization. Should i stop it?

Talk to your doctor: My intuition is telling me that discontinuation or changing the dose may be a consideration although i would try to talk to a doctor about this before proceeding. If you start having thoughts of harm to self or those around you then i would definitely think about getting to an emergency department. Stay safe! ...Read more

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Began taking Prozac (fluoxetine) a week ago. Today I'm really depressed, sad and weepy. Definitely worse, since I'm on it for anxiety. Is this from Prozac (fluoxetine)?

Began taking Prozac (fluoxetine) a week ago. Today I'm really depressed, sad and weepy. Definitely worse, since I'm on it for anxiety. Is this from Prozac (fluoxetine)?

Probably not: Prozac (Fluoxetine) takes up to six weeks to become effective in the treatment of Depression and Anxiety. After one week, it is not likely that you are getting effects from it. However, some patients become depressed that the medication has not caused change. Discuss this with your prescribing physician. ...Read more

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Can Prozac (fluoxetine) accelerate depression?

Prozac (fluoxetine): One old hypothesis was that some severely depressed patients who had thoughts of self-harm & had no energy to carry on the act, when given medication that gave them extra energy fast, that they carried on the act of self-harm before they had the chance to work thru their depression. Again, this is only hypothetical, since data re. The subject are scarce & not much is written about it. ...Read more

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Is Prozac (fluoxetine) a good medication for depression?

Is Prozac (fluoxetine) a good medication for depression?

Excellent: Inexpensive also but like anything else, it's all about you and what works for you. Talk to your doctor. Sometimes we try several until we find what works best for you. ...Read more

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Dr. Heidi Fowler
1,016 doctors shared insights

Fluoxetine (Definition)

Fluoxetine (brand prozac) is an antidepressant in the class known as serotonin selective reuptake inhibitors aka ssris. Fda approved in 1987 for the treatment of major depressive disorder. Subsequently approved for obsessive compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Significantly safer and much better ...Read more


Dr. Alan Ali
737 doctors shared insights

Prozac (Definition)

Prozac is a serotonin reuptake blocker which is a kind of ...Read more