Doctor insights on:
Provocholine is an asthma agent which is a kind of lung drug.
Yes and no: They are both catecholamines, a specific type of chemical class. In the body, there are different type of receptors in tissues which bind catechols with different effects. Dopamine and doubtamine have different affinities for different receptors and thus can have different effects. Kind of like different types of baking sugars...They are all sugars but are used for special purposes and functions. ...Read moreSee 1 more doctor answer
Provocholine is an asthma agent which is a kind of lung drug.
Methacholine test: Mostly it is done where the diagnosis of asthma is doubtful. It should be done under the careful supervisision of a physician who has experience in the bronchial challenge tests. The test can be done in the hospital pulmonary lab or in the office setting with appropriate. Staff and safety equipment to treat asthma like symptoms. The test is still being done when indicated. ...Read moreSee 2 more doctor answers
Reaction to sux: In terms of allergy in the usual sense, it may not exist with succinylcholine. My top concern would be an adverse intrinsic response to exposure to this drug, called malignant hyperthermia. This is life threatening if not immediately recognized, there is genetic predisposition(family history). Other conditions preclude use of this drug too, renal failure, certain neurologic conditions also. ...Read more
Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?
Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more
R/O RAD/ASTHMA: UNLIKELY BUT STOP TO GET BASELINE. RAD and underlying allergies which frequently coexist. You need a through exam blood work /CXR/ PFTS WITH DLCO. Depending on the results treatment will be indicated. You also need a personal peak flow meter to keep track of peak flow and treat accordingly if numbers are low with albuterol. If you are using it a lot you may need a long acting inhaler like advair. ...Read more
Diagnosed with asthma+allergic rhinitis 2years.Methacholine challenge test today:Negative.ImmunoCAP(A-IgE):Total 1114, 93.4 IgE(kU/l), good control?
Likely for asthma: If the methacholine challenge was negative,that means your asthma is under good control which is measured mostly by your quality of life, the number of asthma attacks, and your lung function. The IgE level is not included in measuring control. However it has nothing to do with your allergic rhinitis. ...Read more
Is it possible that succinylcholine drugs(nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure?
The New Spiriva Test: Spiriva inhibits wheezing while the test is used to provoke it so, yes,the test will be affected.At that point maybe call it a "Spiriva Test" in that,if it resists the effects of the methacholine, then it would probably work for you! But,of course,that's not how the test is done.They'd want you off that med for a day or two before doing the test-and any other respiratory meds you take, if possible ...Read more
NO: In general, MAO inhibitors refer to specific prescription antidepressant drugs & are highly regulated. Many foods & herbs have mild MAO inhibiting actions, such as carrots, chocolate, coffee, ginger, grape & onions,but these effects are not clinically significant & they don't need to be avoided if on a med that interacts with MAO inhibitors: http://www.botanical-online.com/english/vegetalmaois.htm ...Read more
Yes.: Your statement is correct.Get a more detailed answer ›
Episodic difficulty with inhale; also chronic rhinitis. Dr doesn't suspect asthma but wishes to rule it out with methacholine test. Effective test?
Can succinylcholine drugs (nicotinic depolarizing neuromuscular blocker) decrease intraocular pressure? Any answers appreciated!
No.: Succinylcholine actually causes an increase in intraocular pressure for about 10 minutes after administration. Classic teaching was not to use succ in people with open globe injuries. There are situations, though, where using succ with other agents that lower IOP is preferred because it makes intubation more smooth, avoiding hypertension and airway reactivity that is worse for the situation anyway ...Read moreSee 1 more doctor answer
Yes: Both the steroid and long acting bronchodilator would likely produce a false-negative test. The minimum one must stay off of Advair would be 2 weeks. On the other hand, if one were to check how the medication works, one can compare the response before and after starting Advair- mostly done in research setting. ...Read more
What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?
None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read moreSee 1 more doctor answer
Excitatory: Histamine is actually classified as an excitatory neurotransmitter in the brain responsible for the sleep wake cycle. Too much of it can keep you awake. That is why it is used in many commercial sleep aides seen with the letters "pm" attached to some kind of pain killer. A common side-effect of a histamine blocker like Diphenhydramine (benadryl) is drowsiness. ...Read more
Because of negative mannitol test & heavy dysnea, Dr. ordered methacholine challenge, but my dna shows pseudocholinesterase deficiency. Safe test?
Methacholine: Did you have PFTs? First do that ,Rrare to use methacholine in the US as those with asthma can have a severe response. Discuss your deficiency and PFTs wtth your doctor. methacholine is metabolized by acethycholinesterase and si resistent to inactivation by pseuodcholinesterase , so that should not be a factor. See http://www.rxlist.com/provocholine-drug/clinical-pharmacology.htm ...Read more
Can an antagonist (propranolol) cause an inhibitory effect via beta-adrenoreceptors in cardiac myocytes?
Beta blockers: Yes.Get a more detailed answer ›
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