Doctor insights on:
Usually effective: Like all medications Provigil (modafinil) works better for some people than it does for others, and there are some people for whom it may not work at all. However, in my experience, it has been a highly effective medication for most people with excessive fatigue. It is indicated for excessive sleepiness caused by sleep apnea, narcolepsy, and shift work, but it is used off label in many ways. ...Read moreSee 1 more doctor answer
It's expensive: But will be generic soon. It is known generically as modafanil and is made by several companies, especially india. Why sun pharmaceuticals can sell modalert 200 mg for 1.59$ and Provigil is $14 is beyond me. Teva has bought cephalon and owns the next 2 companies i line who could make generics. In 2-3 years the price will come down and i'll bet use increases. It's a good medicine. ...Read moreSee 1 more doctor answer
Wakes up the brain: Modafanil (provigil) appears to increase the activity of the brain wakefulness centers without causing a significant increase in Dopamine or norepinephrine release (unlike the stimulant medications). This is why its abuse potential is lower than other medications that improve alertness. ...Read moreSee 2 more doctor answers
About an hour: After oral ingestion, should start being absorbed in about 45-60 min, with blood levels stabilizing within 90-120 hrs maximum. If an effect is not experienced by then may need to ramp up dosage, but usually 200 mg daily should work. However, if generic, may not get absorbed as well. And some need Nuvigil instead. ...Read more
About a day: The half life (time it requires for 50% of the medication to be eliminated from the body) is roughly 15 hours. The clinical effects of the medication are typically gone in under a day. The medication is almost completely cleared from your system within a few days. ...Read more
Is there a generic for provigil available in the united states yet? I've tried to find an answer, but have found mixed results.
I take 200 mg of provigil daily to treat narcepsy. After 7 years it is not keeping me awake anymore. Could I have dveloped an immunity to the drug?
Narcolepsy: Check with your physician for the possibility that you may have developed other conditions like hypothyroidism, obstructive sleep apnea, depression, organic brain disorders, lack of exercise or poor sleep habits. He may need to reevaluate your medications. Hope you feel better soon. ...Read moreSee 1 more doctor answer
Wakefulness: Modafinil is classified as a somnolytic, and promotes alertness and wakefulness through selective activation of wake and sleep centers in the central nervous system. The fda has approved its use in nacrolepsy, adjunctive treatment of excessive daytime sleepiness associated with obstructive sleep apnea, and shift-work sleep disorder. Off-label, it's used for adhd and adjectively for depression. ...Read moreSee 1 more doctor answer