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Doctor insights on: Prostrate Biopsy Negatives

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For several years my PSA test has been increasing. Recent prostrate biopsy was negative. What else cause increased PSA?

For several years my PSA test has been increasing.  Recent prostrate biopsy was negative.  What else cause increased PSA?

PSA: PSA or prostate specific antigen is often used as a screening for prostate cancer. It is not very specific for that because elevations can occur in other disease including benign prostatic hypertrophy. A negative biopsy should allow you to rest assured that currently you don't have prostate cancer ...Read more

Dr. Heidi Fowler
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


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How far apart can prostrate biopsy be done if i need a second opinion ?

How far apart can prostrate biopsy be done if i need a second opinion ?

take tissue blocks: You can ask pathology department to give you (or they can send themself) tissue cell block or blocks with your core biopsies and slides, to your second opinion doctor. In this case you do not need to have biopsy again, at least until you hear second opinion.
Be well. Thank you for question. ...Read more

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What can we expect from my husbands prostrate cancer it is in 10percent of the 12 biopsy taken thank you?

What can we expect from my husbands prostrate cancer it is in 10percent of the 12  biopsy taken thank you?

Depends: It sounds as if there is a small amount of cancer in the prostate which is good. However, there are many other factors such as the gleason score, psa, and others that help determine how aggressive the cancer is and whether treatment is needed or not. These need to be discussed with a urologist and/or radiation oncologist expert in prostate cancer treatment. ...Read more

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If a biopsy came back negative why would they want to operate?

If a biopsy came back negative why would they want to operate?

More info needed: More information is needed to answer your question. Remember, however, a negative test is only negative for that one site biopsied. For example, if you put on a blindfold, went our to your front lawn and pulled up a handful of grass and identified that you had no weeds in that handful, can you safely say that you have no weeds on your entire lawn? Provide more info in your next question. ...Read more

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Can someone with veds have a negative or inconclusive biopsy result?

Can someone with veds have a negative or inconclusive biopsy result?

Vascular Ehlers-Dan: If by veds you mean vascular ehlers-danlos syndrome, it is unlikely that a biopsy would be negative. Genetic testing exists to confirm a suspected diagnosis if the first biopsies were all negative and the index of suspicion is still very high. ...Read more

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Fnac report negative, but biopsy shows burkins lymphoma.Is it possible?Why?

Fnac report negative, but biopsy shows burkins lymphoma.Is it possible?Why?

Sampling error: Fine needle aspirate of lymph nodes are not ideal for ruling out abnormal findings. Especially, with lymphomas there may be areas within the ln that are not involved and sampling of these areas may be misleading. Excisional biopsy is the gold standard, as it allows for assessment of individual cells and architecture of lymph node and adequate tissue for specialty workup. ...Read more

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How frequently are false negative results from a biopsy?

Rare but not zero: Pathologic evaluation of breast core biopsy samples has a very low false negative rate. That being said, pathology results need to be reviewed in the context of the imaging and clinical findings. If all three do not match up as concordant, then the possibility of a false negative or sampling error (i.e. missed target) comes into play and repeat sampling/biopsy should be considered. ...Read more

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Can you tell me if a biopsy came back negative how can my dr. Still diagnose me with that disease?

It depends: It depends on the disease. Some diseases are diagnosed solely by biopsy, whereas others are diagnosed by a set of criteria. If the other criteria are present, you can still have the disease, despite a negative biopsy. If you are not convinced, you can always ask for a second opinion. ...Read more

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High psa 9.0 biopsy negative .What now?

High psa 9.0 biopsy negative .What now?

Common situation: Everyone seems to agree that psa is not a "perfect" cancer screening test. If it was everyone with psa elevation would be found to have cancer upon biopy and that isnt the case. It is still the only way of selecting men for biopsy. Continue to have semi-anual psa tests. A second biopsy my be indicated at some future time if it continues to rise over time. ...Read more

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My psa is between 8 and 9 but biopsies are negative - why?

That is what it's...: Clinical significance of psa can widely vary among individual men: high psa doesn't mean we always can find prostate cancer in biopsy; low psa doesn't guarantee no prostate cancer either. More detail on psa-related subjects? To http://formefirst.Com/freeinfoprostate.Html and http://formefirst.Com/newauapsa.Html ...Read more

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When a biopsy comes back negative for cancer, but abnormal in results?

When a biopsy comes back negative for cancer, but abnormal in results?

Could be precancer: A number of cancers are preceded by precancerous lesions. By that we mean the cells are abnormal and architect distorted but the cells have not broken through the basement membrane , the sac surrounding the tubules or glands of the organ . This is not uncommon in the breast , cervix , prostate and the skin , and depending where is commonly treated to prevent progression to cancer. ...Read more

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PSA reading was 8.6. If biopsy is negative, what might the next step be?

Here are some: The option may be: do nothing and watch, but do T/F PSA in 6 mo; repeat biopsy in 4-6 months. However, age, personal risk factors such as family Hx of prostate cancer (PCa), being blacks, & Agent Orange exposure.), PSA moving pattern over the years, DRE finding, etc. together play important role to decide what is the reasonable step. More detail? To http://formefirst.com/FreeInfoProstate.html. ...Read more

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Brother is african american. P s a 9.2, was 8.5 3 months ago. Negative biopsy for p s a 6. Should biopsy be repeated?

High PSA: Due to the increase in a short period of time I would recommend f/u with the Urologist first to see if biopsy would be appropriate. Also PSA can be increased by a few things: like Recent sexual activity (a few days prior to blood work); Recent Upper Respiratory infection/Cold; Recent Prostate infection as well. ...Read more

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Psa 5.2 - 5.8 for 1yr. Three yrs ago psa 3.9 two biopsies -neg. Psa dropped to 3.1 later. Do i wait and see, or do another biopsy?

Possibly: The overall range and trend seems flat and if your dre is normal, until the trend changes it is reasonable to keep a watch q 6 mo with a dre. ...Read more

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I had a pink lesion on my arm biopsied i was just wondering under the dermascope she said she could see negative networks what does this mean thanks?

I had a pink lesion on my arm biopsied i was just wondering under the dermascope she said she could see negative networks what does this mean thanks?

Atypical finding: Assuming she meant negative pigment network. It is an abnormal finding in dermoscopy which when identified is more suspicious for the possibility of melanoma. However, wait for the biopsy results before getting too worried. Dermoscopy findings (depending which source you read) only correlate with the biopsy result only about 75% of the time. ...Read more

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Is it okay to get vaginal biopsy if the leason isn't there anymore i'm scared i had to that went away i had tested negative for cancers?

Please follow up.: I don't know what kind of lesion you had but if a doctor considered biopsying it, it is certainly worth while to follow up to determine any need for further treatment. Just because you can't see it anymore doesn't mean that a lesion isn't there. Sometimes doctors have scopes and special tests to look at cells, called colposcopy. ...Read more

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Question had skin biopsy do they automatically do a cd3 on every skin biopsy & if cd3 is negative does that r/o lymphoma or do u still have to watch?

Question had skin biopsy do they automatically do a cd3 on every skin biopsy & if cd3 is negative does that r/o lymphoma or do u still have to watch?

Complex question!: Cd3 is on t cells. Your doctor is looking for t cells in your skin biopsy, which can be present for many reasons including allergy. It looks like you have autoimmune disease (positive ANA in the past), so your doctor may be checking to see if your skin lesions are related to that. Based on what you've told me, lymphoma does not come to mind! ask your doctor what he/she is thinking! don't worry! ...Read more

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Felt 5 spots near anus 5 wks ago;smear & biopsy 3 days later, both herpes neg, but read they may be inaccurate. Spots still there. Could it be herpes?

Felt 5 spots near anus 5 wks ago;smear & biopsy 3 days later, both herpes neg, but read they may be inaccurate. Spots still there. Could it be herpes?

Need exams & tests: Spots mean different things to different people. You need a thorough exam and serological (blood) tests for any suspected infection including Herpes. ...Read more

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I am 77 years old. A year ago my psa was 7.5. This year it is 10.5 three years ago I had a biopsy, which was negative. I am not taking any medication.?

I am 77 years old. A year ago my psa was 7.5. This year it is 10.5
three years ago I had a biopsy, which was negative. I am not
taking any medication.?

It would be nice to: Know psa level when you were biopsied. Also, your bladder symptoms, family history of longevity. Is sexual ability an issue for you? Do you have any other diseases, since most folks die with prostate cancer rarther than of it. The bottom line is treatments all have costs and side effects, and not every one requires treatments. Symptoms of disase and of treatment need to be balanced. ...Read more

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Psa fluctuates between 9 and 13. had negative biopsy 12 samples. very painful.no local anathesia. might need another. is there a less painful way. 64y?

Psa fluctuates between 9 and 13. had negative biopsy 12 samples. very painful.no local anathesia. might need another. is there a less painful way. 64y?

Here are some ...: How long have your PSA been fluctuating between 9 & 13 ng/ml. how many times have you been biopsied. & have you had UTI ? To learn & explore current thoughts on PSA/prostate cancer. please take time to peruse the articles in http://www.formefirst.com/FreeInfoProstate.html. How to make you less painful form P-biopsy? Most of men tolerate this procedure well under topical anesthesia or nerve block ...Read more

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LSIL and HPV+, 3 months later, negative biopsy. What does this mean?

LSIL and HPV+, 3 months later, negative biopsy. What does this mean?

Need for follow-up: The good news is that you do not have cervical disease. However, since you have HPV you should get regular PAP smears.
You are young enough that you should get HPV vaccine. ...Read more

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How long does it take to recover from a brain biopsy? (assuming it is negative)

How long does it take to recover from a brain biopsy? (assuming it is negative)

Short time: A stereotactic biopsy does not take much time to recover from at all (hours to a couple of days). Headache is the most common side effect. Open brain biopsy done via a "burr hole" would take slightly longer -- but both are very standardized and neurosurgeons are the specialists with the longest number of years of training: 9 years after medical school. They know what they are doing. ...Read more

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I got hvi virus detected after colposcopy, biopsy is negative.What to do?Tahank you

HIV: If you mean hiv, this is a very treatable condition and you should be seen by a physician or clinic that deals with this illness. Good luck and best wishes. ...Read more

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Is it standard when doing a skin biopsy to run cd3 and if it's negative can it still be turning into lymphoma?

Is it standard when doing a skin biopsy to run cd3 and if it's negative can it still be turning into lymphoma?

No, it is not: A skin biopsy would only be done if there is a visible lesion(s) over the skin.Then a microscopic exam will reveal if there is any abnormal cells in the skin biopsy which may look like a lymphoma , in which case lymphoma markers like cd3 and others like it may be tested. ...Read more

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Please advise: the tumor cells stain negatively for cd56 and positively for e-cadherin in both biopsy blocks. ?

Please advise:
the tumor cells stain negatively for cd56 and positively for e-cadherin in both biopsy blocks.  ?

See your doctor: Problems like these can only be correctly handled by your doctor in person. He/she needs to listen to you, perform an examination and possibly run labs or other tests. That's the only way he/she can find out what's going on and what to do about it. ...Read more

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Hello, My PSA went up to a 5, recommended prostate biopsy. The result was negative. Should be concerned? Thanks!

Follow-up: A negative biopsy result is good, however, you should follow your doctor's advice for continued vigilance and periodic check-ups. There is no need to worry. ...Read more