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Doctor insights on: Prostigmin Side Effects

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To restore BP in hypotensive crisis should they give you prostigmin (neostigmine)?

To restore BP in hypotensive crisis should they give you prostigmin (neostigmine)?

Possibly: This may be necessary. To goal is to address the cause of the low blood pressure. For example, if due to acute bleeding, replacement of blood volume is appropriate. If due to vasodilation, vasoconstrictors are helpful. In severe crisis, combinations of treatments are needed. ...Read more

Dr. John Savarese
53 doctors shared insights

Neostigmine (Definition)

Neostigmine is a nasal preparation which is a kind of ...Read more


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How can you restore blood pressure in hypotensive crisis? Prostigmin (neostigmine)?

How can you restore blood pressure in hypotensive crisis? Prostigmin (neostigmine)?

HyPOtensive crisis?: I've never heard of hyPOtensive crisis. HyPERtensive crisis, yes. When someone's blood pressure is dangerously low, that's called "shock." There's hemorrhagic shock & septic shock & shock from low cardiac output due to MI or CHF, etc. Drugs commonly known as pressors such as dopamine, dobutamine, and levarterenol are used to keep BP up. I'll defer to my intensivist colleagues for better answers. ...Read more

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How can neostigmine works and its mechanics?

How can neostigmine works and its mechanics?

Anticholinesterase: neostigmine inhibits the activity of the enzyme responsible for breaking down the acetylcholine, the ubiquitous neurotranmitter. In anesthesia it is commonly used to reverse action of curare-like medications that cause muscle relaxation/ temporary paralysis necessary to facilitate surgery. Hope that helps ...Read more

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During a hypotensive crisis how is neostigmine used?

Hypotension: neostigmine isn't used in hypotensive crisis, read this: https://books.google.com/books?id=5zd_W_PUwvYC&pg=PA193&lpg=PA193&dq=hypotensive+crisis+and+neostygmine&source=bl&ots=SWufyt2QhL&sig=5vWWEMUYn3pGZ3CDqoR_Gdq3hsM&hl=en&sa=X&ei=tj1aVYuZIcLKogSxyILwCg&ved=0CCAQ6AEwAA#v=onepage&q=hypotensive%20crisis%20and%20neostygmine&f=false ...Read more

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Can you tell me how could neostigmine works and its mechanics?

Yes!: acetyl choline is the neurotransmitter across the neuromuscular junction. It is removed by hydrolysis. Neostimine slows this process and therefore increases acetylcholine concentration at this site ...Read more

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What are the medical benefits of botox, curare, neostigmine, atropine?

Very broad question: You have asked a very broad question and therefore difficult to answer. ...Read more

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Why should why should a woman who is planning a pregnancy that use neostigmine stop use it particullary before two weeks ?

Less time is ok.: Neostigmine has a very short "half-life". This means that it's eliminated from the body quickly. Virtually all it will be gone within a week of stopping. Studies show elimination of 1/2 of it in just 90 minutes. Another 1/4 in 90 more minutes. Another 1/8 in 90 more minutes, etc...So you can see by doing this math that Neostigmine will be completely gone from your system in quite a short time. ...Read more

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Why should why should a woman who is planning a pregnancy that use neostigmine stop use it particullary before two weeks why two weeks?"

Caution in pregnancy: Neostigmine is category c in pregnancy, meaning that we really don't know how safe it is because it hasn't been studied. You have to weigh the risks and benefit to the mother against that unknown. Particularly before conception there may be a higher risk of affecting the fetus during organogenesis, when all of the vital organs are being created. Second trimester may be a little safer. ...Read more

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Why neostigmine is not a drug for treatment of Alzheimer's disease?

Why neostigmine is not a drug for treatment of Alzheimer's disease?

Doesn't get in brain: Neostigmine's chemical structure (quaternary amine) does not allow it to cross the blood brain barrier, so it does not affect cholinesterases in the brain. ...Read more

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Dr. Arthur Balin
11 doctors shared insights

Prostigmin (Definition)

Prostigmin is a nasal preparation which is a kind of ...Read more