Doctor insights on:
HyPOtensive crisis?: I've never heard of hyPOtensive crisis. HyPERtensive crisis, yes. When someone's blood pressure is dangerously low, that's called "shock." There's hemorrhagic shock & septic shock & shock from low cardiac output due to MI or CHF, etc. Drugs commonly known as pressors such as dopamine, dobutamine, and levarterenol are used to keep BP up. I'll defer to my intensivist colleagues for better answers. ...Read more
Anticholinesterase: neostigmine inhibits the activity of the enzyme responsible for breaking down the acetylcholine, the ubiquitous neurotranmitter. In anesthesia it is commonly used to reverse action of curare-like medications that cause muscle relaxation/ temporary paralysis necessary to facilitate surgery. Hope that helps ...Read more
Hypotension: neostigmine isn't used in hypotensive crisis, read this: https://books.google.com/books?id=5zd_W_PUwvYC&pg=PA193&lpg=PA193&dq=hypotensive+crisis+and+neostygmine&source=bl&ots=SWufyt2QhL&sig=5vWWEMUYn3pGZ3CDqoR_Gdq3hsM&hl=en&sa=X&ei=tj1aVYuZIcLKogSxyILwCg&ved=0CCAQ6AEwAA#v=onepage&q=hypotensive%20crisis%20and%20neostygmine&f=false ...Read more
Why should why should a woman who is planning a pregnancy that use neostigmine stop use it particullary before two weeks ?
Less time is ok.: Neostigmine has a very short "half-life". This means that it's eliminated from the body quickly. Virtually all it will be gone within a week of stopping. Studies show elimination of 1/2 of it in just 90 minutes. Another 1/4 in 90 more minutes. Another 1/8 in 90 more minutes, etc...So you can see by doing this math that Neostigmine will be completely gone from your system in quite a short time. ...Read more
Why should why should a woman who is planning a pregnancy that use neostigmine stop use it particullary before two weeks
why two weeks?"
Caution in pregnancy: Neostigmine is category c in pregnancy, meaning that we really don't know how safe it is because it hasn't been studied. You have to weigh the risks and benefit to the mother against that unknown. Particularly before conception there may be a higher risk of affecting the fetus during organogenesis, when all of the vital organs are being created. Second trimester may be a little safer. ...Read moreSee 1 more doctor answer
Different uses: Acetylcholinesterase inhibitors are the first line of treatment due to their safety and ease of use. Pyridostigmine (Mestinon) is the usual choice. Neostigmine is available but not commonly used. Edrophonium is an acetylcholinesterase inhibitor but does not come in an oral form. It is mainly used as a diagnostic agent for MG. ...Read more
There are none...: Even the strongest opiates only "take the edge off" for people in chronic pain. Meds are only one part of dealing with the pain. A useful tool, but pain is so necessary for survival that we are not "allowed" to monkey with it much. In acute pain, the transition from miserable to less miserable can be great. In chronic pain, it's just part of the plan. ...Read more
So call your doc: This is the HT public information site.We are thousands of volunteer docs based primarily in the US who answer medical questions.We do not offer treatments. State medical boards require a physician/patient relationship,a retrievable record,recent exam with vital signs for prescribing.Failure to do so can lead to loss or restriction of license. It may seem minor to you but it is not. ...Read moreSee 1 more doctor answer
Sometimes: Sometimes they are. For the most part, expired drugs simply lose potency once past their expiration date. There are, however, some drugs that actually become harmful if taken after they expire. As such, it is best to throw out any medications you have after a year. ...Read more
ASPRIN: Actually no one has decided on 'safest'. Asprin has been around since before you were born and unless you take too much (yes, too much of anything isnt good) most people are okay with it. If the pain it too severe for asprin you need to know what causes it. Good diagnosis is called for. See the dr. ...Read more