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Doctor insights on: Prostate Cancer Gleason Score

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Gleason score eqivalent without biopsy?

Not possible: There is no way to get a gleason score without a biopsy. The grade is determined by the pathologist's interpretation of an actual tissue sample, and the two most commonly seen patterns are added together to get a gleason score. ...Read more

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Dr. Barry Rosen
4,344 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Prostate cancer treatment?

Prostate cancer treatment?

First question: Is whether treatment is necessary, depends on gleason score and psa. Treatment may not add value to you. Watchful waiting follows your psa #, rate of rise. If your gl >/= 7, psa > 10ng/ml, best option is radiotherapy, +/- anti-hormone. Get a few opinions. Do not act in haste. ...Read more

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What is metastatic prostate cancer?

What is metastatic prostate cancer?

Metastasis: in general, metastasis refers to a cancer that has gone from the organ of origin to other parts of the body ...Read more

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Symptoms of prostate cancer metastasis?

Prostate cancer: The most common metastatic site would be bones-although it also can go to other sites- lymph glands, lung, liver etc.. Symptoms will depend on the location of metastases. Bone pain, fractures would be the symptoms of bony mets. If spread to the adjacent area such as bladder area- blood in urine, lower abdomen pain, prob wi/ urination, obstruction can happen. Weight loss, weakness are common too. ...Read more

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What is prostate cancer survival rate?

What is prostate cancer survival rate?

Age related: With a high p OM yjr 50-60 years of age prognosis is guarded. Over 70 a stage iii prostate cancer can do well on a drug like lupron (leuprolide). ...Read more

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Stage 4 prostate cancer bone pain?

Stage 4 prostate cancer bone pain?

Bone pain: When prostate cancer spreads it tends to go to the bone where it can cause pain. Tell your urologist or oncologist about the pain and they can order an x-ray. It can be treated so please don't think it is hopeless. ...Read more

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I'm concerned about prostate cancer metastasis. Where can prostate cancer spread?

I'm concerned about prostate cancer metastasis. Where can prostate cancer spread?

In theory, prostate cancer cells can spread anywhere in the body: In practice, though, most cases of prostate cancer metastasis occur in the lymph nodes and the bones. Prostate cancer metastasis occurs when cells break away from the tumor in the prostate. The cancer cells can travel through the lymphatic system or the bloodstream to other areas of the body. More commonly prostate cancer metastasis can occur in the: Bones, Lymph nodes, Lungs, Liver, Brain. Rare locations of prostate cancer metastasis include: Adrenal glands, Breasts, Eyes, Kidneys, Muscles, Pancreas, Salivary glands, Spleen. If you've been diagnosed with prostate cancer and you're concerned about prostate cancer metastasis, talk with your doctor about your risk of prostate cancer metastasis and your treatment options. ...Read more

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Describe breast cancer staging according tnm?

Describe breast cancer staging according tnm?

Tumor,Nodes,Mets: The t, n, m system classifies breast cancers based upon tumor size(t), lymph node status(n), and presence of cancer elsewhere in the body(m). Stage i is limited to small cancers +/- microscopic ln disease. Stage ii describes tumors 2-5cm +/- ln disease. Stage iii is for more advanced tumors (>5cm, skin/chest wall involvement) +/- multiple/distant ln. Stage IV describes metastatic disease. ...Read more

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Symtoms of prostate cancer?

Symtoms of prostate cancer?

Asymptomatic: Prostate cancer at its early stages is generally without symptoms or warning signs. As prostate cancer grows, it may cause urinary obstructive symptoms. In advanced stages with bone metastasis it may present with bone pain. ...Read more

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What are psa and tumor markers for prostate bone metastasis?

What are psa and tumor markers for prostate bone metastasis?

PSA means: Prostate specific antigen. Men all have a level of psa if they have a prostate. Arbitrary normal levels are age & race dependent. If you have prostate cancer, and bones are involved, your psa will likely be greater than 10 ng/ml. Psa levels that double in short intervals are more likely to do this. However, very undifferentiated prostate cancers may not generate psa, and one can have bony mets. ...Read more

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Is prostate cancer preventable?

Is prostate cancer preventable?

Maybe: There have been numerous studies on prostate cancer prevention. There are two related drugs, Finasteride and dutasteride, which were shown in large trials, to reduce the risk of developing prostate cancer by about 25%. The fda did not approve these drugs for cancer prevention because a higher percentage of the cancers which did develop were high grade, or more aggressive. ...Read more

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Prognosis for hormone refractory metastatic prostate cancer with pathological fracture?

Prognosis for hormone refractory metastatic prostate cancer with pathological fracture?

Prostate cancer: This is an advanced stage of prostate cancer; the good news is there are many new drugs and treatments for men in this stage that have been shown to extend life; in this stage survival is extremely variable from months to years isn't impossible. ...Read more

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How is prostate cancer diagnosed? 

How is prostate cancer diagnosed? 

History/Exam/Tests: Prostate cancer (cap) does not generally have symptoms until it is fairly advanced and untreatable. Thus screening for cap has been done by asking for any family history of cap, examining the prostate through a rectal exam and by checking a test called prosate specific antigen(psa). If the exam or psa are abnormal, an ultrasound-guided biopsy through the rectum acquires tissue to assess for cap. ...Read more

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Treatment for prostate cancer by stage.

Treatment for prostate cancer by stage.

Disease continuum: There is a disease continuum from localized disease through advanced metastatic castration resistant disease. Generally localized disease is treated with local therapies such as surgery or radiation and disease that either recurs or is more advanced is treated initially with hormonal therapy. Immune therapy and chemotherapy may be used after. ...Read more

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Is stage 3c breast cancer curable?

Is stage 3c breast cancer curable?

Yes: ...In theory, with aggressive multi modality therapy (surgery plus chemo plus radiation +/- hormones +/- herceptin). The risk of relapse is high but you do all you can and hope for the best. If this is about you, fight well and best wishes. ...Read more

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Esophegeal cancer markers?

Esophegeal cancer markers?

Not for early CA: Unfortunately , non to detect very early stages ca 125 , ca 19.9 , cea will be elevated at later stages, used to monitor the disease. Ca 72.4 cyfra 21.1 being tested .Scca (also for ca of cervix other squamous ca ). ...Read more

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Is brachytherapy helpful for a prostate cancer patient who has metastasized cancer cells?

Is brachytherapy helpful for a prostate cancer patient who has metastasized cancer cells?

No.: Brachytherapy is used in the treatment of localized prostate cancer, or cancer that has not spread outside of the prostate gland. If a patient has metastatic disease, treatments need to be systemic, with the aim of halting the growth & spread of the cancer throughout the body. These treatments include hormonal therapy, chemotherapy, and immunotherapy. Urologists & medical oncologists can help. ...Read more

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Does a high psa score mean cancer?

Does a high psa score mean cancer?

Not always: Usually the change in a psa value from one to the next is more concerning than the sole value itself. Rate of change is important too. Psa is a tool that helps us determine who is at highest risk for prostate cancer and therefore who needs a biopsy to diagnose cancer. Normal values slowly increase as one ages. However psa values over 20ng/ml are very concerning for cancer and need a biopsy. ...Read more

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Dr. Walter Husar
7 doctors shared insights

Prostate (Definition)

The prostate is a gland that lies at the base of the bladder and surrounding a segment of urethra. It secretes a milky fluid that is discharged by excretory ducts into the urethra during the emission of semen. It is clinically important because enlargement of the prostate with age, and prostate cancer are two common ...Read more


Gleason Score (Definition)

This is how pathologists grade prostate cancer on needle biopsies. It ranges from 1-5 and the.Most two common patterns are added to get a gleason score which can range from 2-10 the higher the score ...Read more