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Doctor insights on: Propoxyphene Toxicity

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Effect of darvon-n tablet(propoxyphene napsylate)?

Effect of darvon-n tablet(propoxyphene napsylate)?

Off market: The drug was pulled off the market in the us last year due to adverse cardiac effects. ...Read more

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Dr. Tanya Russo
16 doctors shared insights

Propoxyphene (Definition)

Propoxyphene is a drug that increases narcotic effects which is a ...Read more


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Is digoxin toxic?

Is digoxin toxic?

Digoxin: the drug digitalis which in a refined form is digitalis is one of the oldest poisons used by man. The ancient Egyptians called in 'bulls blood' and killed with it. It must be used properly, in tightly controlled dosage and followed by the physician. It has been used therapeutically for ages, recently it has lost popularity and present suggestions are to use it very cautiously ...Read more

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IS tyLENOL (acetaminophen) 3 aDDICTIVE?

IS tyLENOL (acetaminophen) 3 aDDICTIVE?

Yes it can be: Tylenol (acetaminophen) #3 has codeine in it and that can be habit-forming and dependency can occur. ...Read more

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Why is nac (n-acetylcystein) administered to antidote tylenol (acetaminophen) toxicity instead of using gluathione exogenous supplement directly?

Why is nac (n-acetylcystein) administered to antidote tylenol (acetaminophen) toxicity instead of using gluathione exogenous supplement directly?

Standard protocol ;: Good question. Nac is well-proven to work ; is the standard protocol. Glutathione might work as well or better but i'm unaware of any studies showing it works. Also, standard glutathione is poorly absorbed orally. It might work well given IV but has a short shelf-life ; is not generally available in er's. See http://www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc436956/ good luck with your condition! ...Read more

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Liver damage from tylenol (acetaminophen) use?

Liver damage from tylenol (acetaminophen) use?

Question?: I'm not sure what the question is - if you are asking if tylenol (acetaminophen) can damage the liver, then yes. The fda recently decreased the maximum dose for tylenol (acetaminophen) to 3, 000 mg per 24 hours in healthy adults. For kids or those with medical problems, the dose is even less. Overdosing on the active ingredient in tylenol (acetaminophen) is one of the worst deaths i've ever seen. ...Read more

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What is antidote for digitalis toxicity?

The $$$$ Digibind (digoxin immune fab)..: Digitalis has been in used for many years...Started in ancient time (the foxglove plant)--and can useful in select patients. Since we have other medical options, digitalis is not that frequently used these days--but we still do. In case of acute/severe toxicity, Digibind (digoxin immune fab) is an antidote available for use, but it is an expensive medication. Consult your doc...Good luck. ...Read more

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Is long-term oxycodone (opana) use safer than long-term vicodin or norco (hydrocodone and acetaminophen) use, since the former contains no acetaminophen which harms the liver?

Is long-term oxycodone (opana) use safer than long-term vicodin or norco (hydrocodone and acetaminophen) use, since the former contains no acetaminophen which harms the liver?

Possibly: Most medications are processed through your liver. Normally, a healthy liver will easily process and eliminate acetaminophen. However, if the liver is abnormal or exposed to excess amounts of acetaminophen, then severe harm could result. Remember that all opioids (opana, vicodin, etc) must be taken carefully under your physician's guidance. ...Read more

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Why is chlordiazepoxides, diazepam, clofibrate, barbiturates contraindicated in renal failure?

Why is chlordiazepoxides, diazepam, clofibrate, barbiturates contraindicated in renal failure?

Impaired elimination: All drugs that are taken are eventually metabolized and eliminated from the body. Although liver enzymes perform the bulk of metabolizing of these agents, elimination of the drug and their metabolites relies, to varying degrees, on the kidney. If the kidneys are failing, elimination is impaired, and a toxic buildup of the drug and/or its metabolites is possible. ...Read more

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Are morphine tabs (msir) more addictive than methadone?

Are morphine tabs (msir) more addictive than methadone?

MS and methadone: I disagree. Both are potent narcotics that can activate the disease of addiction in susceptible patients. The physical withdrawal from Methadone is more prolonged than the withdrawal from morphone but they both can activate addiction. Methadone is used in substitution therapy for other opiate addictions because it gets across the blood-brain barrier more slowly and causes less euphoria & sedation. ...Read more

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Can naloxone substitute for oxycodone overdose?

Can naloxone substitute for oxycodone overdose?

No: Naloxone is the antidote to an oxycodone overdose. Naloxone is an opiate-receptor competitive antagonist, which means it blocks the receptors that oxycodone needs to bind to in order to exert its effect. ...Read more

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What is propoxyphene napsylate?

What is propoxyphene napsylate?

Darvocet: Propoxyphene is a very weak opioid with many side effects, including seizures, that is now off the market. It is a poor analgesic and i would not recommend it. ...Read more

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I'm immune to the hydromorphone actions, but not other opioids such as demerol (meperidine hydrochloride) (meperidine) or morphine?

I'm immune to the hydromorphone actions, but not other opioids such as demerol (meperidine hydrochloride) (meperidine) or morphine?

Sounds confusing: In that hydromorphone is metabolized into morphine, and that is the effective agent in our bodies. There are people who may lack the enzymes to metabolize certain drugs, and this has been reported in some people with codeine, where the enzyme that metabolizes it to morphine is absent. It is possible you have something similar. Sometimes it is that you have not gotten the right dose by right route. ...Read more

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How toxic are CNS depressants?

How toxic are CNS depressants?

Depends: Alcohol is an example-- depends how much you use and for how many years. Benzos and barbituates are also examples. If you've been using alcohol or these meds multiple times a day for a long time, you don't want to suddenly stop them, as that can cause seizures and other dangerous consequences. Discuss weaning them with your doctor. Alcohol in moderation, and use your meds as prescribed to you! ...Read more

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Is paracetamol more toxic to the liver than opiates?

Is paracetamol more toxic to the liver than opiates?

A Tough Comparison..: (1) tylenol (acetaminophen) (paracetamol) is a direct liver toxin and had been a leading cause of acute liver failure in the U.S. & britain. (2) opiods, rarely, may cause idiosyncratic liver toxicity (a different mechanism) that may require relatively higher doses. Neither drug should be taken in excess of routine dosing guidelines. ...Read more

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Which is most effective; hydrocodone, fentanyl, oxycodone, or methadone?

Which is most effective; hydrocodone, fentanyl, oxycodone, or methadone?

No such thing: It is not what is most effective, it is what is best for you. I am sure your doctor will choose the safest type of opioid to treat your pain and see how you respond. If you do not respond, then he/she may try a different opioid. The most important thing is to find out what is causing a pain bad enough to require and opioid. ...Read more

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Toxicity (Definition)

Toxicity is the degree to which a drug or a substance can harm ...Read more