Doctor insights on:
Propofol Overdose In Children
They rescue you.: Propofol is a useful drug that induces anesthesia but can be dangerous. It should only ever be given by a dedicated, anesthesiologist or a crna. It can cause apnea and a significant drop in blood pressure which can cause a heart attack, stroke or even death if left untreated. All of this is preventable and treatable with trained supervision. In the right setting, Propofol is a very safe drug. ...Read more
Several effects: There is no such thing as an absolute Propofol overdose. This is a very useful med for sedation and anesthesia. But, it will lower blood pressure, and in high doses stop breathing. It will cause a patient to relax, so that even if he/she is trying to breathe, the tongue can fall back and obstruct breathing. For all these reasons, an anesthesiologist must always supervise Propofol administration. ...Read more
Variable: Multiple factors contribute to the optimal dose such as patient comorbidities, weight and drug tolerance. The dose can be calculated as 1-2.5 mg/kg given as 40mg every 10 seconds until induction. ...Read more
First: Propofol is a controlled substance that cannot even be prescribed. It must be obtained from an inpatient pharmacy directly to the department using it. Therefor the only way for someone to get access to it outside of a hospital is theft. For short in-patient use addiction is not possible. ...Read more
Propofol: Gilbert's syndrome (the liver is impaired in excreting bile pigment/bilirubin) is surprisingly common. Maybe 2-5% of Ameicans have the problem. Most don't even know. In general, propofol has the same safety profile for patient's with Gilbert's as w/o.However, if you have a poor diet, drink alcohol every day then you can be so liver toxic that ANY anesthetic is a bad idea ...Read more
No interaction: Propofol induces sleep. Fentanyl is a pain reliever, a narcotic, in the same drug class as morphine and Demerol (meperidine hydrochloride). There is no direct interaction between the two. But when used in combination they can cause breathing to slow or stop, so must be used with caution by anesthesia professionals. Both can also cause blood pressure to drop. ...Read more
Not all anesthesia: Agents cause nausea. Nausea is associated with anesthesia agents and also specific surgeries that increase the risk of nausea (ponv), like breast, pelvic, eye and ear surgeries. Also increasing the risk of nausea in patient risk factors like history of vertigo or motion sickness. Another factor is pain drugs like narcotics used for postoperative pain. Propofol was used to treat nausea in cancer pat. ...Read more
Small amounts: It would be hard to use Propofol for light sedation. It is the drug we reach for when requiring deep sedation which means that the patient is not responsive to verbal stimuli. There is a fine line between deep sedation and general anesthesia (airway is easily obstructed unless someone is there to maintain patency). One can look up dosages but everyone is different and require different amounts. ...Read more
Maybe: Propofol can last in your system for hours or days depending on the dose given and your own body's metabolism of the drug. Another concern is: for what procedure or reason were you given propofol in the first place. Your dizziness may have something to do which what your underlying condition was, or a complication of that. You may want to talk to the doctor who gave you the propofol. ...Read more
Causes sleep: Propofol brings about sleep quickly and allows a patient to wake up quickly, with few side effects and very little nausea. It is useful at the start of general anesthesia or as a sedative by itself. Valium can be a good sedative but it lasts a long time in the system. It also can cause prolonged amnesia, which Propofol will not. Propofol must be given only under anesthesiologist supervision. ...Read more
What type of sedeation is most commonly used for an endoscopy? Sedeation with or without propofol?
Propofol has a short half life of a few minutes and neither of the techniques you mention are needed.
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No, if......: All medications can be dangerous if used inappropriately. However, if used correctly and within accepted guidelines, medications, including propofol, are considered safe and effective. Propofol should only be used by anesthesiologists who have been properly trained on its use. ...Read more
Maybe: Propofol can be used in combination with other medicines for status epilepticus. Typically it is not a first line agent to stop a seizure or status epilepticus. If it has gotten to the point where Propofol is being employed, then the patient is likely in an ICU and multiple agents have already been tried. ...Read more
It depends: For surgery lasting minutes to hours the patient wakes up in 5-30 minutes. If given for days in the ICU it may take days to wake up. You can get "propofol infusion syndrome" in ICU sedation characterized by severe metabolic acidosis, hyperkalemia, lipidemia, rhabdomyolysis, hepatomegaly, and cardiac/renal failure. ...Read more
What to do if I do not want to be awake at all, I'm reading on propofol and it being safe, is this true?
Propofol: Can be a safe drug if monitored carefully and continuously and being able to properly respond, otherwise there are safer medications ...Read more
At times: The answer depends on the reason for the cystoscopy. If a diagnostic "look see" is needed to look for reasons for blood in the urine, for example, sedation is usually not necessary although some lidocaine jelly may be used. If a biopsy may be needed or a more involved procedure necessary, then sedation or some other form of anesthesia may be used. ...Read more