Doctor insights on:
Prolia Or Evista
Why are prolia and raloxifene considered by some to be better alternatives to the other treatments for osteoporosis and are the side effects common?
Denosumab: Denosumab is an excellent treatment for persons with a low bone mass and at increased risk of fracture. These fractures occur much more often in folks twice your age so you need to have an extensive workup to find out why you might need a drug to prevent bone loss and actually increase your bone health. ...Read more
Treat osteoporosis: Denosumab is an antibody that works in a way similar to bisphosponates (like fosamax) to decrease bone turnover and decrease the risk of fractures in people with osteoporosis who have had a previous fracture. Studies suggest that it is more effective than bisphosphonates. In your age group, unless you have severe osteoporosis or a previous fracture, you would not be a candidate for it. ...Read more
Only one: Hi. The only active ingredient in Prolia is denosumab, a monoclonal antibody that binds a signaling molecule, RANK Ligand (RANKL), that bone forming cells (osteoblasts) secrete that activates bone resorbing cells (osteoclasts). RANKL activates the osteoclasts to break down bone. Denosumab interrupts that, and preserves bone mass and architecture. ...Read more
Many options: Depending on your personal presentation, including your DEXA (bone density) scan results, your the frax® score (a tool developed by who to evaluate fracture risk of patients) and your vit d and ca++ levels, there are other meds such as fosamex, actonel, boniva, reclast, (zoledronic acid) to name a few. Osteoporosis treatment is important, so I recommend discussing with a provider who is educated in it. Good luck. ...Read more
There is no: Permanent cure for osteoporosis, Raloxifene (evista) mimics estrogen's beneficial effects on bone density in postmenopausal women, without some of the risks associated with estrogen. Taking this drug may also reduce the risk of some types of breast cancer. Hot flashes are a common side effect. Raloxifene also may increase your risk of blood clots. ...Read more
Prolia: Both medications are anti-resorptive, meaning they prevent breakdown of your bone. Reclast (zoledronic acid) has been used for longer so has more side-effects that are known. It also can not be used if you have kidney problems. Prolia is an injection every 6 months (vs. 12 months with reclast). Both medications tend to be very well tolerated. ...Read more
Adrenal Insuf, NO immunity, MANY med iss. Finished Forteo DON'T want 2 take Reclast/Prolia. Endo mad at me. But, is there anything else?
This is a LOT of: Information. I see that you make many submissions on Health Tap. It is important to remember that we can NOT diagnose or make medical / medication recommendations/ treatment on the general Health Education portion of HealthTap. Health Tap Prime or Concierge can be used for that purpose. ...Read more
I just got diagnosed with osteopenia and I am 41 yes old and was wondering if this is unusual they have me on evista (raloxifene) had a DEXA done?
Mam has had her 4th prolia injections today. Also takes 2 calcichew d3 tablets daily. Never had side effects. I'm worried now is it safe. She is 87?
I assume she is taking prolia for osteoporosis. This medication has been deemed safe for the treatment of osteoporosis by the FDA. However, it does have several potential side effects and depending on other medical conditions of your mother, some of these side effects may be more likely. Check the following link for more info:
http://www. Drugs. Com/prolia. Html
All the best,
Ariel ...Read more
For me, 3 yrs ago Reclast=5% improvement, Prolia for 2 yrs=little improvement, but 10% LOSS hip neck! Why? And, now must be off for 3 yrs, scary! Thx!
Treating osteoporosi: Reclast (zoledronic acid) is an antiresorptive medication (like Fosamax, Boniva, etc) that is given IV. It will prevent further loss but will not rebuild bone. 5-10% increase/decrease is likely within the margin of error of a DEXA scan. Recombinant human parathyroid hormone rPTH (Forteo) is an injectable medication that does rebuild bone and increase density. RPTH cannot be given with a history of cancer. ...Read more
Maybe: Prolia represents a new category of osteoporosis treatment that is effective and has convenient twice yearly dosing. It appears much more effective than the bisphosphonates and rivals Forteo with much more convenience. It is expensive if not covered by your insurance. Whether it is best for you or not depends on many factors which would require more information about a specific patient. ...Read more
.?: I'm not sure what you are asking but I recommend you discuss this with your physician/oncologist. ...Read more
Breast? Likely no: The primary trial of Raloxifene for breast chemoprevention was limited to 5 years of use to match the standard of 5 years of tamoxifen. Recent data suggest a benefit of 10y of tam over 5 years for treatment of invasive er+ breast cancer. However, the benefit of the extra five years is not seen until after year 10. That suggests that the benefit of that drug holds for 5 years after it is stopped. ...Read more
Does Alendronate and Prolia produce the same results? I want to choose just taking only one and my t-score is -2.7.
Essentially: There are no good "head to head" trials of the meds so I can not say for sure one does not do slightly better than the other, but the avail studies do not show this. They do work very diff though and some individuals may respond better to one than the other. However, the choice of which to use often has to do with other factors. For example GERD & Barret's Esoph may sway you one way cost another. ...Read more
I just had my 1st dose of Prolia on 11/20. Just started w/ a tooth problem which needs to be pulled. What are my options?
More info needed..: Your prior medical history is crucial in determining the proper course of care. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. The oral surgeon extracting the tooth should consult with your primary physician. Together they will determine the best course of care and manage any complications. ...Read more
No due to blood clot: Both Evista (raloxifene) and strontium alone can cause blood clots. The combination has the risk of increasing the risk of blood clots even more. Blood clots can be fatal. There is no good data on the combination, so it's not recommended. ...Read more
Perhaps: Evista (raloxifene) if taken to reduce breast cancer in post-menopausal women is usually taken just for 5 years but there is no limit number of years if taken for osteoporosis. There may be an increase risk of ovarian cancer the longer it is taken. Increased risk of stroke or blood clots is not necessarily related to duration of intake. ...Read more
Blood clotting: The most common is worsening of menopausal symptoms, but blood clots (particulary in the legs) are much more serious. Do not use if you're a smoker or have a problem with clotting. ...Read more
How long will the dizziness and nausea lasr from prolia shot? What can I do to overcome these symptoms?
Difficult to answer: Most side effects are self limiting and should resolve quickly. If they continue then the side effects could be treated with other medications. Discuss this with the doc who did your injection. ...Read more