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Doctor insights on: Progressive Systemic Sclerosis Involving Esophagus

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Abnormal FDG activity involving pleural thickening in Rt lower lateral lung base compatible with inflammatory VS early neoplasticism disease. Meaning?

Abnormal FDG activity involving pleural thickening in Rt lower lateral lung base compatible with inflammatory VS early neoplasticism disease. Meaning?

Pleural thickening: It means that the pleural thickening is metabolically active(i.e. It is not chronic scarring, which would be inactive). The 2 main possibilities for this, as you mention, are an active inflammation, which is benign, or neoplastic disease(tumor). Speak with your doctor. If the answer is not clear based on your entire clinical picture, biopsy could be needed to determine what it is. ...Read more

Dr. Corey Clay
3 doctors shared insights

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more


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Is multiple sclerosis progressive and fatal?

Is multiple sclerosis progressive and fatal?

Prog.disease: There is a variant form of MS that is very aggressive that can lead to coma or death. However most of the other forms do not have such a grave prognosis. If left untreated >30 % of patients will develop significant disability within 20->25 years after onset. Life expectancy is shortened only slightly, death usually results from secondary complications. ...Read more

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Is chronic diffuse sensorimotor peripheral neuropathy with predominant external & secondary demyelinative changes a long-term disability?

Is chronic diffuse sensorimotor peripheral neuropathy with predominant external & secondary demyelinative changes a long-term disability?

It can be: Sensorimotor peripheral neuropathies have many types and various causes. Some of them can be disabling, even long term in some cases. A thorough search will have to include blood tests and urine tests. In some cases spinal tab (lumbar puncture) can be necessary. In delineating the diagnosis. ...Read more

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What is progressive neuro-degenerative disease or any neuro-degenerative or atrophy cerebellar diseases or mental diseases?

What is progressive neuro-degenerative disease or any neuro-degenerative or atrophy cerebellar diseases or mental diseases?

Example: Neurodegenerative illnesses that affect the cerebellum may be the different forms of multiple system atrophy, such as OPCA. Other neurodegenerative illnesses (that do not affect the cerebellum) include Alzheimers, Parkinsons, and ALS. ...Read more

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Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Is amyotrophic lateral sclerosis a type of multiple sclerosis (ms)?

Not similar diseases: Als is very different, and is a disease of "mis-folded proteins" like alzheimers and parkinson's, and all of these affect older people. Ms is an autoimmune disease afflicting younger patients who have hereditary susceptibilities and environmental exposures. Ms can be successfully treated and controlled, but ALS does not respond well to current therapies. ...Read more

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MRI=enhancingT2hyperintense foci in both cerebellar regions may represent demyelinating disease. Other less likely metastasis or any infiltrative?

MRI=enhancingT2hyperintense foci in both cerebellar regions may represent demyelinating disease. Other less likely metastasis or any infiltrative?

Complex question.: We will need to discuss your symptoms to figure out the significance of any such "findings" on the MRI. This isn't the forum to discuss- use HealthTap Prime or talk to your doctor / neurologist. In the mean time, obtain the MRI pictures & upload the pictures + report onto your computer. A metastasis in BOTH cerebellums, symmetrically, is ridiculously improbable. Can't say much more here. Good luck ...Read more

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Disseminated peritoneal disease with long segment bowel wall thickening, multiple hepatic and renal nodules - are in favour of neoplastic etiology?

Disseminated peritoneal disease with long segment bowel wall thickening, multiple hepatic and renal nodules - are in favour of neoplastic etiology?

7 YO? Can't post yet: Have to be 17 to post. Seven years old is too young to post, and requires speaking to your pediatrician about your questions until you're old enough to post. Thanks! ...Read more

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Multilobulated pulmonary mass w/calcifications in left upper lobe. Neoplastic disease vs inflammatory/infectious process. rule out metastatic disease ?

Multilobulated pulmonary mass w/calcifications in left upper lobe. Neoplastic disease vs inflammatory/infectious process. rule out metastatic disease ?

In general...: IN GENERAL, a multilobulated mass is more likely malignant, one with calcifications is less likely. As in much else, size matters, with bigger being more worrisome. If you're smoker, more likely malignant, if from place of endemic TB or histoplasmosis, risk of chronic infection rises. You'll need to be evaluated by a pulmonologist, who will very likely recommend biopsy. ...Read more

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Xray recently shows severe joint space narrowing involve the patellofemoral compartment with underlying subchondral sclerosis & osteophyte formation?

Xray recently shows severe joint space narrowing involve the patellofemoral compartment with underlying subchondral sclerosis & osteophyte formation?

Osteoarthritis: These are classical findings of osteoarthritis being spelled out by the radiologist. Osteoarthritis develops as we lose the cartilage that is not seen on X-ray and usually leaves a "joint space" on films. During this degenerative cascade, sclerosis happens to the bone under cartilage and bone tries to increase its surface area when weakened by forming spurs called osteophytes. Good luck. ...Read more

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Can masturbation lead to autoimmune diseases like lupus or multiple sclerosis?

NO relationship: This question has been asked and answered numerous times on this site. Masturbation does NOT cause disease or blindness! ...Read more

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M77 , biopsy of vastus laterilus muscle says "secondary neurogenic atrophy with super imposed inflmatory myopathy" which disease this may be?thanks

M77 , biopsy of vastus laterilus muscle says "secondary neurogenic atrophy with super imposed inflmatory myopathy" which disease this may be?thanks

Your doctor needs: to findout if you have any cause for your neuropathy. This can be from many causes - usually diabetes or alcohol or other drugs are the cause. You need to go over with your doctor what possible things in your life are responsible for it. The secondary inflammation suggests you have a compromised immune system or slightly weakened one. People usually do not get inflammation of the muscle. ...Read more

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Can the systemic inflammation from undifferentiated connective tissue disease cause intermittent dizziness ?

Can the systemic inflammation from undifferentiated connective tissue disease cause intermittent dizziness  ?

Inflammatory disease: Sounds like you have been given the dx of fibromyalgia. Otherwise, you have a very vague problem which is questionable in its diagnosis. You are much more likely experiencing vertigo due to the serious medications you are on versus systemic inflammation. Both Plaquentil and Cymbalta (duloxetine) are well known for causing vertigo. I would suggest talking with your rheumatologist about alternate drug treatment. ...Read more

Dr. Pierre Moeser
185 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


Esophagus (Definition)

This is the muscular structure built like a tube that connects your throat to the stomach though which food ...Read more