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Doctor insights on: Progressive Systemic Sclerosis Involving Esophagus

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What are the tests for systemic sclerosis?

What are the tests for systemic sclerosis?

Biopsy, blood: In advanced stages, no test is required. It if the diagnosis is suspected early, a skin biopsy will usually prove the diagnosis. In the blood, the scl-70 and the anti-centromere antibody tests are the most helpful. Other tests may be positive. The above two blood tests often help differentiate the disease from other conditions. Other tests are used to evaluate but not diagnose the condition. ...Read more

Dr. John Landi
3 doctors shared insights

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more


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Is there treatment for systemic sclerosis?

Is there treatment for systemic sclerosis?

Not really: D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist. A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines.The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more

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My father was diagnosed with systemic sclerosis. Should I be worried for him?

My father was diagnosed with systemic sclerosis. Should I be worried for him?

Timely help is key: Systemic sclerosis remains a challenging disease in the field of rheumatology where struggle for a cure or even targeted therapy is ongoing. Most patients donot have adverse outcome but in case of lung and kidney involvement prognosis can be poor. There are many other areas of the body affected by it but they don't seem to be dangerous rather patient lifestyle and medication can help. ...Read more

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Do you ever diagnose systemic sclerosis sine scleroderma and if so, what are the the clinical signs and symptoms of this disease?

Extremely rare: Systemic sclerosis sine scleroderma is a fibrosing condition of the internal organs including the GI tract, pulmonary artery, and lungs, but lacking the skin features if scleroderma. Systemic sclerosis is a rare condition to begin with, and systemic sclerosis sine scleroderma accounts for <10% of patients. Diagnosis might include antibody tests or abnormal biopsy of affected internal tissues. ...Read more

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I am a 20 year old female with systemic sclerosis. I have a pain in the left side of my chest which has got worse over the past couple of weeks.

I am a 20 year old female with systemic sclerosis. I have a pain in the left side of my chest which has got worse over the past couple of weeks.

Try this: Is it worse when you take a deep breath, cough or press on the chest wall? Concern about possible fluid on the chest area. Consider chest X-ray. ...Read more

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What is systemic sclerosis?

What is systemic sclerosis?

Systemic sclerosis: An autoimmune disease characterized by thickening and loss of elasticity of the skin. It may have systemic manifestations as well such as trouble swallowing and acid reflux. ...Read more

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What were your initial symptoms of systemic sclerosis?

What were your initial symptoms of systemic sclerosis?

Raynaud's : Raynaud's 1st but other systems can be involved - skin tightening, each person is different and on occasion the skin can be normal. ...Read more

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What is the definition or description of: Systemic sclerosis?

What is the definition or description of: Systemic sclerosis?

Systemic sclerosis: This is based on several criteria and includes skin thickening; Raynaud's phenomenon; abnormal lab studies (anti-Scl 70); abnormal nail capillaries; and in some case lung disease. For more detail, be sure to consult a rheumatologist. ...Read more

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Will systemic sclerosis kill me?

Will systemic sclerosis kill me?

It can: Systemic sclerosis is a progressive disease. It can be fatal by causing heart failure, respiratory failure, and any number of other complications. ...Read more

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Do people with systemic sclerosis have a lot of pain?

Usually not: The problem with scleroderma is more related to complications. If pain is from the raynaud's phenomenon, vasodilation therapy might solve it. ...Read more

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What are the initial symptoms of scleroderma/systemic sclerosis?

Raynaud's: Tight skin is characteristic but there can be a variety of other symptoms such as raynaud's whihc is usually the first symptom, shortness of breath, chest pain, trouble swallowing, other GI symptoms, etc. Each person with scleroderma has a different set of symptoms and different type of scleroderma involvement. ...Read more

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Can somebody tell, just by looking, if you have facial symptoms of systemic sclerosis?

Can somebody tell, just by looking, if you have facial symptoms of systemic sclerosis?

Sometimes: The skin around the face can be tight in patients with systemic sclerosis. The hands, face, and fingers are typically involved early and can be observed by someone with experience in patients with systemic sclerosis. ...Read more

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Will systemic sclerosis kill me if I don't get treatment? Is it just a slow disease?

Yes: Systemic sclerosis is a slow progressive but relentless disease. Current treatments are of limited efficacy. Having said that, you should follow closely with a rheumatologist. ...Read more

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Does anyone know about systemic sclerosis?

Does anyone know about systemic sclerosis?

Much research,but: D-penicillamine might work, and there a number of studies suggesting this, but no long term double blind studies exist. A recent report suugest that a drug CellCept (mycophenolate mofetil) might be of value, and there are those that use mtx or tetracyclines.The major advances are ability to control BP and treat pulmonary hypertension. We can deal with esophgeal spasm and reflux. Nothing great at present for underlying dx. ...Read more

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I have systemic sclerosis I have just come back from Spain and have swollen feet and ankles and a red rash on both shins and really swollen watery eye?

I have systemic sclerosis I have just come back from Spain and have swollen feet and ankles and a red rash on both shins and really swollen watery eye?

Be checked if...: Your briefed report suggests you have a long-term chronic health issue. Hence, make a follow-up appointment with the existing doctor soon. If the symptoms significantly differ from what you used to have or become unbearable, visit ER/urgent care. To put all the related things for good care together correctly, follow instructions in articles listed in http://formefirst.com/onDealSickness.html. ...Read more

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What other conditions could 'focal dermal sclerosis' with telangiectasia on a skin biopsy indicate besides scleroderma?

What other conditions could 'focal dermal sclerosis' with telangiectasia on a skin biopsy indicate besides scleroderma?

Depends on clincial: This depends on your clinical status. It could be scleroderma but may not and may be something else. You need an evaluation ...Read more

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Lupus and scleroderma are connective tissue diseases but eds is also. What exactly is connective tissue disease? Is lichen sclerosis related

SLE and: Scleroderma are autoimmune diseases, eds is a 'flaw' of development of elements in the connective tissue. Part of the connective tissue may be affected by immune cells interactions.. ...Read more

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Hi, it seems like scleroderma. I have dysmotility of esophagus and les 3mmhg but rheuma. Said no scleroderma and my doctor disagree all tests negative?

Your question is?: You have not asked a question. Esophageal issues by themselves do not make a diagnosis of scleroderma. Your rheumatologist is correct unless you have other issues consistent with scleroderma. ...Read more

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I have dysmotility of esophagus and GERD 3mmhg (scleroderma). Will be posibble to do fundoplication in the future if my esophagus will be ok? Thanks

I have dysmotility of esophagus and GERD 3mmhg (scleroderma). Will be posibble to do fundoplication in the future if my esophagus will be ok? Thanks

Not indicated: Esophageal dysmotility is usually a strong contraindication for consideration of fundoplication surgery, as that surgery may cause worsening symptoms or an obstruction. ...Read more

Dr. Pierre Moeser
182 doctors shared insights

Scleroderma (Definition)

An autoimmune disease in which there is excessive thickening of the connective tissues. This can cause skin tightening, rash, difficulty swallowing, and in severe cases affect ...Read more


Esophagus (Definition)

This is the muscular structure built like a tube that connects your throat to the stomach though which food ...Read more