Doctor insights on:
Progressive Supranuclear Palsy In Children
Very unlikely: From the Mayo clinic, progressive supranuclear palsy "typically affects people around the age of 60, and is virtually unknown in people under the age of 40." http://www.mayoclinic.org/diseases-conditions/progressive-supranuclear-palsy/basics/definition/CON-20029502?p=1 ...Read more
...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more
Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more
Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more
Cannot look up: Similar to but worse prognosis than Parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more
Good History & exam!: Good history & exam are the keys. In expert hands, that is all you really need. However, a new test/imaging procedure called datscan can determine if the person is suffering from a true Dopamine degenerative state (parkinsonian sundrome) or not, it cannot destinguish b/w these parkinsonian syndromes, however! ...Read more
Falls: Usually starts with falls swallowing difficulties are also seen. ...Read more
YES: The previous name for psp was steele-richardson-olszewski syndrome. ...Read more
Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more
Good Rx, but no cure: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more
PSP: This is a condition that is similar to Parkinson's disease but the rigidity is more through the trunk than in the limbs, and people have difficulty moving their eyes. It is also more aggressive than Parkinson's disease with rare benefit with medications and rapid progression. ...Read more
Read on: PSP ( Steel Richardson Syndrome) is a progressive degenerative condition in the involuntary movement disorder genre. See a neurologist specialist in this type of illness. There is no cure (as in most conditions!) and the treatment not ideal Your doctor will tell you how to cope with it and will give palliative treatment ...Read more
Good Rx available!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more
Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear).
It is central; demyelinating conditions occur in the peripheral nervous system. ...Read more
Psp is progressive supranuclear palsy in the group of parkinsonism plus=no response to treatment with Dopamine
it is thought to be genetic and cause degeneration and changes in the neurotransmiters in basal ganglia and other locations in brain--less understood compare to parkinson disease. ...Read more
Not likely: No one knows for sure what causes it. It is a degenerative neurologic disease a little similar to Parkinson's disease in a comparable area of the brain. The cause may be genetic, viral, though no one really knows. It is very very rare. ...Read more
Unlikely: Though anesthetics do have an effect on the brain, it is unlikely that they would cause this problem. The anesthetics that we use can decrease blood flow to certain areas of the brain, so they might unmask a pre-existing psp, but again that is speculation. I would talk to your neurologist about this problem. ...Read more
I was diagnosed with progressive supranuclear palsy 5 years ago. Are there any good clinical trials available for psp?
Try this: Psp is frustrating and unfortnately progressive. Also, there just aren't many doctors with a ton of experience with this "rare" condition. See: http://www.Pspinformation.Com/ you may be able to find what you are looking for, or at least get connected to a support network. ...Read more
I have progressive supranuclear palsy. My biggest issue is that my eyelids are hard to open (90% of the time). Are there any good solutions for this?
Some to try...: Visual problems are common complaints with psp. Sometimes this is due to spasms of the muscles causing the eyes to stay closed. Other times the eyes involuntarily point down or don't line up together. Treatment is difficult, but options for are available to try. See http://www.Pspinformation.Com/disease/psp/psp-eyesight.Shtml. ...Read more
Parkinson's Disease: Progressive supracuclear palsy is a severe form of parkinsonism. It is characterized by no or minimal response to levodopa, prominent subcortical cognitive impairment, severe balance disorder, axial dystonias, and the classical inability to voluntarily move eyes in vertical plane. In contrast, idiopathic parkinson's disease commonly has better response to levodopa, resting tremors, slower decline. ...Read more
Good thots, but: At this time, there is NO cure for progressive supra nuclear palsy (AKA, Steele, Richardson, Olezewski Syndrome). It seems a variant of Parkinson's but does not respond to the usual Parkinson's meds. Much ongoing research may provide breakthroughs, and if you have it or know someone who does, find a nearby Movement Disorder Specialist who has research. ...Read more
What are some alternate treaments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?
PSP: With any of these other forms of medicine, you would need very skilled, experienced professionals to work with you alongside your conventional neurologist. Many conventional physicians are becoming trained in Ayurveda and homeopathy -- i'm sorry, but i know little about siddha although this one originated in india like ayurveda. For homeopathic physicians, you can see: http://tinyurl.Com/lgsovco. ...Read more
Can you suggest any alternative treaments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?
Stem cells : This is a neurologic condition which has no real cure. I currently am implanting stem cells for patients with this condition, into the CSF. These are autologous cells from your own fat. IRB-approved patient-funded study. Contact 949-642-6787 for more details. Make sure you have a second opinion on the diagnosis. ...Read more
What are some alternative treatments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?
Collaborative care: Psp is a rare degenerative disease of the brain involving movement & balance as well as changes in mood, behavior and personality. Conventional medicine has no cure. Homeopathy does not treat the specific pathological condition, but can help the person by applying the single homeopathic medicine called for by his/her specific experience. You need a very well-trained homeopath to work with you. ...Read more
The right doctor: I believe it is important to be seen by a movement disorders neurologist for this neurodegenerative disease. This is a very difficult disease to treat. A patient may need very high doses of levodopa. Oftentimes issues such as feeding tubes are at the fore. A specialist will have more experience dealing with this rare disease and may have other options (i.e. Clinical trials) available. ...Read more
Multidisciplinary: While there is no single effective medication to stop the progression of psp; some short term modest benefit has been shown with bromocriptine for the rigidity, Botox for dystonia and sialorrhea, methylcellulose for dry eyes, and cognitive stimulation/physical exercise for cognitive function and gait and balance training. ...Read more
Above nuclei: This refers to damage of nervous system structures above the nuclei of affected areas of palsy; typically, this involves those cranial nerves controlling ophthalmic muscles in Progressive Supranuclear Palsy, a neurodegenerative disorder. ...Read more
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