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Doctor insights on: Progressive Supranuclear Palsy Emedicine

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Is progressive supranuclear palsy a demyelinating disease?

Is progressive supranuclear palsy a demyelinating disease?

PSP: Progressive supranuclear palsy: the disorder's long name indicates that the disease begins slowly and continues to get worse (progressive), and causes weakness (palsy) by damaging certain parts of the brain above pea-sized structures called nuclei that control eye movements (supranuclear). It is central; demyelinating conditions occur in the peripheral nervous system. ...Read more

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Palsy (Definition)

...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more


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How is progressive supranuclear palsy (psp) diagnosed?

How is progressive supranuclear palsy (psp) diagnosed?

Cannot look up: Similar to but worse prognosis than parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more

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Could anesthesia cause progressive supranuclear palsy (psp)?

Could anesthesia cause progressive supranuclear palsy (psp)?

Not likely: No one knows for sure what causes it. It is a degenerative neurologic disease a little similar to Parkinson's disease in a comparable area of the brain. The cause may be genetic, viral, though no one really knows. It is very very rare. ...Read more

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Is parasupranuclear palsy genetic?

Is parasupranuclear palsy genetic?

Not usually: If you are referring to progressive supranuclear palsy, this is not felt to be genetic. This typically occurs more frequently in males in their 60's. ...Read more

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What can cause progressive supranuclear palsy?

What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

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What is the prognosis for progressive supranuclear palsy?

What is the prognosis for progressive supranuclear palsy?

Supranuclear palsy: Unfortunately, no known treatment other than supportive care for supranuclear palsy exists. The average person is in their 60's when diagnosed. Life expectancy averages 7 years after diagnosis. ...Read more

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What are the treatments for progressive supranuclear palsy?

What are the treatments for progressive supranuclear palsy?

Good Rx available!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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What is the difference between progressive supranuclear palsy (psp) and Parkinson's disease?

What is the difference between progressive supranuclear palsy (psp) and Parkinson's disease?

Parkinson's Disease: Progressive supracuclear palsy is a severe form of parkinsonism. It is characterized by no or minimal response to levodopa, prominent subcortical cognitive impairment, severe balance disorder, axial dystonias, and the classical inability to voluntarily move eyes in vertical plane. In contrast, idiopathic parkinson's disease commonly has better response to levodopa, resting tremors, slower decline. ...Read more

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What are progressive and pseudo bulbar palsy?

What are progressive and pseudo bulbar palsy?

Upper motor neuron: Pseudobulbar palsy is a disorder of nerves located near the base of the brain, that connect the higher brain centers with the lower spinal cord. Most commonly affects chewing, swallowing, speech, emotional outbursts sometimes. It has multiple causes and the underlying disease will determine how progressive it is; examples are parkinson's, als, certain strokes, ms, brain trauma. ...Read more

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What are some alternate treaments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?

What are some alternate treaments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?

PSP: With any of these other forms of medicine, you would need very skilled, experienced professionals to work with you alongside your conventional neurologist. Many conventional physicians are becoming trained in ayurveda and homeopathy -- i'm sorry, but i know little about siddha although this one originated in india like ayurveda. For homeopathic physicians, you can see: http://tinyurl.Com/lgsovco. ...Read more

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Would acupuncture help for progressive bulbar palsy?

Would acupuncture help for progressive bulbar palsy?

Unlikely: Acupuncture may be useful for pain, however, and could be used as palliation, but will have no effect whatsoever on progressive bulbar palsy, a variation of classical motor neuron disease. ...Read more

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Is erb duchenne palsy reversible?

Yes: 80% of cases improve without any help, within 1 week. Otherwise consulting a pediatric neurologist and physiotherapy, after 1 week is recommended. ...Read more

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How can you treat progressive supranuclear palsy?

How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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What are some alternative treatments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?

What are some alternative treatments for progressive supranuclear palsy (psp) like ayurveda, homeopathy or siddha?

Collaborative care: Psp is a rare degenerative disease of the brain involving movement & balance as well as changes in mood, behavior and personality. Conventional medicine has no cure. Homeopathy does not treat the specific pathological condition, but can help the person by applying the single homeopathic medicine called for by his/her specific experience. You need a very well-trained homeopath to work with you. ...Read more

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Cerebral palsy and myoclonus related?

Cerebral palsy and myoclonus related?

Spasticity: CP and myoclonus involve over active stretch reflexes. They are caused by release of these reflexes from higher cortical brain control. ...Read more

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Can you please suggest treatment for progressive supranuclear palsy ( psp)?

Can you please suggest treatment for progressive supranuclear palsy ( psp)?

Multidisciplinary: While there is no single effective medication to stop the progression of psp; some short term modest benefit has been shown with bromocriptine for the rigidity, Botox for dystonia and sialorrhea, methylcellulose for dry eyes, and cognitive stimulation/physical exercise for cognitive function and gait and balance training. ...Read more

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What is the proper treatment for progressive supranuclear palsy?

The right doctor: I believe it is important to be seen by a movement disorders neurologist for this neurodegenerative disease. This is a very difficult disease to treat. A patient may need very high doses of levodopa. Oftentimes issues such as feeding tubes are at the fore. A specialist will have more experience dealing with this rare disease and may have other options (i.e. Clinical trials) available. ...Read more

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Treatment for progressive gait imbalace and progressive dysarthria slurred speech?

Treatment for progressive gait imbalace and progressive dysarthria slurred speech?

Uncover cause: Likely best to see a neurologist. There are multiple problems which can cause this, and treatment follows diagnosis. ...Read more

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Dr. Robert Hutchman
37 doctors shared insights

Progressive Supranuclear Palsy (Definition)

This is a condition that is similar to Parkinson's disease but the rigidity is more through the trunk than in the limbs, and people have difficulty moving their eyes. It is also more aggressive than Parkinson's disease with rare benefit with ...Read more


Dr. Justin ORourke
30 doctors shared insights

Supranuclear Palsy (Definition)

This refers to damage of nervous system structures above the nuclei of affected areas of palsy; typically, this involves those cranial nerves controlling ophthalmic muscles in Progressive Supranuclear ...Read more