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Doctor insights on: Progressive Supranuclear Palsy

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Dr. Robert Hutchman
35 doctors shared insights

Progressive Supranuclear Palsy (Overview)

Progressive supranuclear palsy is a rare condition in which a person has a degenerative brain disease that damages nerve cells in the parts of the brain that control eye movements, breathing, swallowing, speech, muscle coordination, balance, etc...


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How can you treat progressive supranuclear palsy?

How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Dr. Robert Hutchman
35 doctors shared insights

Progressive Supranuclear Palsy (Overview)

Progressive supranuclear palsy is a rare condition in which a person has a degenerative brain disease that damages nerve cells in the parts of the brain that control eye movements, breathing, swallowing, speech, muscle coordination, balance, etc...


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What are the symptoms that characterize progressive supranuclear palsy?

What are the symptoms that characterize progressive supranuclear palsy?

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

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Living with Cerebral Palsy (Checklist)

Learn about CP. The more you know, the more you can help your child
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Treat your son or daughter as you would a child without disabilities
once
Learn from professionals how to meet your child’s special needs
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Don't be ashamed to ask for help from family and friends
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I was diagnosed with progressive supranuclear palsy 5 years ago. Are there any good clinical trials available for psp?

I was diagnosed with progressive supranuclear palsy 5 years ago. Are there any good clinical trials available for psp?

Try this: Psp is frustrating and unfortnately progressive. Also, there just aren't many doctors with a ton of experience with this "rare" condition. See: http://www.Pspinformation.Com/ you may be able to find what you are looking for, or at least get connected to a support network. ...Read more

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What are the tests for progressive supranuclear palsy?

What are the tests for progressive supranuclear palsy?

Good History & exam!: Good history & exam are the keys. In expert hands, that is all you really need. However, a new test/imaging procedure called datscan can determine if the person is suffering from a true Dopamine degenerative state (parkinsonian sundrome) or not, it cannot destinguish b/w these parkinsonian syndromes, however! ...Read more

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I have progressive supranuclear palsy. My biggest issue is that my eyelids are hard to open (90% of the time). Are there any good solutions for this?

I have progressive supranuclear palsy. My biggest issue is that my eyelids are hard to open (90% of the time). Are there any good solutions for this?

Some to try...: Visual problems are common complaints with psp. Sometimes this is due to spasms of the muscles causing the eyes to stay closed. Other times the eyes involuntarily point down or don't line up together. Treatment is difficult, but options for are available to try. See http://www.Pspinformation.Com/disease/psp/psp-eyesight.Shtml. ...Read more

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What can cause progressive supranuclear palsy?

What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

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What is the proper treatment for progressive supranuclear palsy?

What is the proper treatment for progressive supranuclear palsy?

The right doctor: I believe it is important to be seen by a movement disorders neurologist for this neurodegenerative disease. This is a very difficult disease to treat. A patient may need very high doses of levodopa. Oftentimes issues such as feeding tubes are at the fore. A specialist will have more experience dealing with this rare disease and may have other options (i.e. Clinical trials) available. ...Read more

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What are the treatments for progressive supranuclear palsy?

What are the treatments for progressive supranuclear palsy?

Good Rx available!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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Is possible for progressive supranuclear palsy to be cured / get better?

Is possible for progressive supranuclear palsy to be cured / get better?

Good Rx, but no cure: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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How do you exactly prevent progressive supranuclear palsy?

You cannot: Psp is progressive supranuclear palsy in the group of parkinsonism plus=no response to treatment with Dopamine it is thought to be genetic and cause degeneration and changes in the neurotransmiters in basal ganglia and other locations in brain--less understood compare to parkinson disease. ...Read more

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What can cause progressive supranuclear palsy?

Tau protein D/O: No, tau protein deposits & neurofibrillary tangles in neurons cause the death of these cells. Because they are in some similar areas as parkinson's disease, psp can appear similar clinically, but there are clear differences. Treatment approaches are roughly the same with different areas needing most attention. Primarily balance/falls/injury, did inhibiting dementia & dysphagia/aspiration. ...Read more

See 1 more doctor answer
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How can you treat progressive supranuclear palsy?

Good Rx Available!!!: Dopamine meds for physical parkinsonism: Azilect (mao-b selective inhibitor) & sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx & watch for side effects. Avoid Dopamine agonists (requip xl/mirapex er/neupro)--too side effect prone for psp patients. For dementia: namenda, paired with Exelon patch or aricept. For psychosis: seroquel or clozaril. Remember, response is variable, but worthwhile. ...Read more

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How is progressive supranuclear palsy (psp) diagnosed?

Cannot look up: Similar to but worse prognosis than parkinson's disease sharing the rigidity and poverty of movements, inability to look up with head kept straight. ...Read more

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What are the tests for progressive supranuclear palsy?

Good History & exam!: Good history & exam are the keys. In expert hands, that is all you really need. However, a new test/imaging procedure called datscan can determine if the person is suffering from a true Dopamine degenerative state (parkinsonian sundrome) or not, it cannot destinguish b/w these parkinsonian syndromes, however! ...Read more

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What is the prognosis for progressive supranuclear palsy?

Supranuclear palsy: Unfortunately, no known treatment other than supportive care for supranuclear palsy exists. The average person is in their 60's when diagnosed. Life expectancy averages 7 years after diagnosis. ...Read more

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What are the complications of progressive supranuclear palsy?

Falls: Usually starts with falls swallowing difficulties are also seen. ...Read more

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What are the symptoms that characterize progressive supranuclear palsy?

Brain studies: This is a term reserved for conditions that affect the connection between nuclei controlling the eye movements with the centers in the brain usually in the frontal lobes. Inability to look up is a common finding. ...Read more

Palsy (Definition)

...is a corruption of French "paralise" from Latinized Greek "paralysis." In the old days it meant any kind of persistent weakness. To this day Parkinson's disease is also called "paralysis agitans" which is a Latin translation of Dr. Parkinson's original name for it, the "shaking palsy." We've obviously reborrowed the full form "paralysis" into English as well; today ...Read more


Dr. Justin ORourke
29 doctors shared insights

Supranuclear Palsy (Definition)

This refers to damage of nervous system structures above the nuclei of affected areas of palsy; typically, this involves those cranial nerves controlling ophthalmic muscles in Progressive Supranuclear ...Read more