Doctor insights on:
I have resistant refractory cutaneous dermatomyositis. I've tried all the traditional as well as ivig and rituxan (rituximab) have failed. What is prograf?
Autoimmune suppressi: Tacrolimus or Prograf or Advagraf is an immunosuppressive drug used mainly in organ transplant to reduce organ rejection. It has also been useful in atopic eczema and in severe uveitis ( Inflammation of the colored portion of the eye ) Side effects can be severe. Patient must be under specialty care throughout the treatment. Topical use can cause irritation and burning sensation used for eczema ...Read more
I had a liver transplant on 05/23/2006 and a right hip replacement on 07/13/2011. I take 3 mg of prograf and baby aspirin for blood thinning. I have been taking 1000 mcg biotin for 7 years. Is 5000 mcg biotin safe for me?
Has anyone here taken prograf or cellcept (mycophenolate mofetil) and noticed any increase in blood sugar?
Two types : First those related to immunosuppression. It affects t cell immunity so you can get viruses (like CMV and ebv) and rarely lymphoma. Second idiosyncratic side effects including elevated creatinine, high blood pressure and high potassium. Seizures, tremor. Hair loss. Despite all of these side effects, one of the best drugs for transplant patients. Can be used very safely. ...Read more
Nephrotoxicity: Most concerning long-term adverse effect of Program (tacrolimus) is nephrotoxicity (damage to the kidneys). The drug has a narrow therapeutic index and therefore the blood level of the drug is often monitored to avoid side effects. Other known side effects include tremor, elevated blood pressure, elevated blood glucose, and hair loss. ...Read more
Active investigation: The short answer is for as long as you keep the graft. However, there are ongoing trials that look to minimize the dose or eliminate tacrolimus by substitution with other agents. The reason is this drug is in a class called calcineurin inhibitor agents that may result in chronic scarring and loss of kidney function over time. You should discuss this with your transplant team. ...Read more