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Doctor insights on: Prograf

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I have resistant refractory cutaneous dermatomyositis. I've tried all the traditional as well as ivig and rituxan (rituximab) have failed. What is prograf?

I have resistant refractory cutaneous dermatomyositis. I've tried all the traditional as well as ivig and rituxan (rituximab) have failed. What is prograf?

See details: Prograf (tacrolimus) is an immunosuppressive med that is usually used after organ transplant to prevent organ rejection. It has been also used to treat certain autoimmune skin diseases. In this instance its action is similar to prednisone. ...Read more

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Tacrolimus (Definition)

This is an immunosupressive drug used after organ transplantation or to sometimes treat refractory effects ...Read more


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Can you tell me more about tacrolimus, prograf ?

Can you tell me more about tacrolimus, prograf ?

Autoimmune suppressi: Tacrolimus or Prograf or Advagraf is an immunosuppressive drug used mainly in organ transplant to reduce organ rejection. It has also been useful in atopic eczema and in severe uveitis ( Inflammation of the colored portion of the eye ) Side effects can be severe. Patient must be under specialty care throughout the treatment. Topical use can cause irritation and burning sensation used for eczema ...Read more

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Do you have to get blood tests every week if on prograf?

Do you have to get blood tests every week if on prograf?

Depends: Tacrolimus (Program) is a immunosuppressive drug that has a narrow therapeutic index. Once you are started on the medication, you will need to get your levels checked until they are in the target range and then at least once a month. ...Read more

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For post kidney transplants, what is your duration of prograf use?

For post kidney transplants, what is your duration of prograf use?

In most instances,: a transplant recipient will be on tacrolimus (Prograf) as long as the transplanted organ continues to function. However, if adverse effects of the drug may lead to switching the drug with another class of agent. ...Read more

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Has anyone here taken prograf or cellcept (mycophenolate mofetil) and noticed any increase in blood sugar?

Has anyone here taken prograf or cellcept (mycophenolate mofetil) and noticed any increase in blood sugar?

Yes: Prograf is potentially beta cell toxic and can induce diabetes in some patients. There could be some alternatives in some cases, discuss with your transplant physicians. ...Read more

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Prograf (tacrolimus) causes what sort of side effects?

Prograf (tacrolimus) causes what sort of side effects?

Two types : First those related to immunosuppression. It affects t cell immunity so you can get viruses (like CMV and ebv) and rarely lymphoma. Second idiosyncratic side effects including elevated creatinine, high blood pressure and high potassium. Seizures, tremor. Hair loss. Despite all of these side effects, one of the best drugs for transplant patients. Can be used very safely. ...Read more

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What are the long term side effects of daily doses of prograf?

What are the long term side effects of daily doses of prograf?

Nephrotoxicity: Most concerning long-term adverse effect of Program (tacrolimus) is nephrotoxicity (damage to the kidneys). The drug has a narrow therapeutic index and therefore the blood level of the drug is often monitored to avoid side effects. Other known side effects include tremor, elevated blood pressure, elevated blood glucose, and hair loss. ...Read more

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How do the transplant doctors decide how much or how long to give you prograf?

Active investigation: The short answer is for as long as you keep the graft. However, there are ongoing trials that look to minimize the dose or eliminate tacrolimus by substitution with other agents. The reason is this drug is in a class called calcineurin inhibitor agents that may result in chronic scarring and loss of kidney function over time. You should discuss this with your transplant team. ...Read more