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Doctor insights on: Prognosis Of Trisomy 13

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What is trisomy 13?

What is trisomy 13?

Chromosome error: Humans have 23 pairs of chromosomes(c) making up our dna.When the egg or sperm form, the (c) pairs are supposed to split up with 1 (c) of each pair going to the egg or sperm.If the 13 (c) does not split & both go into an egg, fertilization will add a 3rd from dad & a trisomy 13 will begin to form. The imbalanced (c) causes malformations, miscarriage or early death. ...Read more

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Trisomy (Definition)

Ordinary chromosomal traits require a pair of chromosomes to determine the traits. Occasionally, as a mistake in cellular division, there is a tripling of one of the chromosomes. When these occur, they usually cause unpleasant, and sometimes deadly conditions in the inheritor of these traits (e.g. Down's). Many we do not know about as they are ...Read more


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What population is affected by trisomy 13?

What population is affected by trisomy 13?

?? odd question ??: Humans of any race, culture,ethnic group, social status, etc. can have a baby with trisomy 13. ...Read more

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Interested to know how does a person inherit trisomy 13?

Interested to know how does a person inherit trisomy 13?

Genetic Mutation: Whenever you make germ cells (sperm and eggs) your body mixes up some of your genetic material and then separates it into discrete packets called chromosomes. You have 23 chromosomes in each germ cell. Sometimes in the process of making germ cells, the mechanism for sorting them out can get rusty (especially with age) and you can end up with an extra copy of number 13 -- t13. ...Read more

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I heard that certain people are more likely to get trisomy number 13 patau syndrome than others, why is that?

Child of older mom: Increasing maternal age increases the risk for chromosome disorders, highlighted by trisomy 21 (down syndrome) but applying to rarer trisomies like the trisomy 13 causing patau syndrome (1 in 8000 births or so). Risks for trisomy increase gradually with maternal age, going from <1 in 2000 under 30 to ~ 1 in 50 over age 40, with age 35 arbitrarily set as high risk (~1 in 200). ...Read more

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Is there any hope for baby with trisomy 13?

Is there any hope for baby with trisomy 13?

No.: Trisomy 13 is a uniformly lethal genetic anomaly; affected individuals lead very short and rudimentary lives without quality. ...Read more

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Is it true that trisomy 13 caused by inbreeding?

Is it true that trisomy 13 caused by inbreeding?

Not true: Trisomy 13 (3 copies of chromosome 13 in all your cells) is caused by an error in the way one of your two chromosome 13s move when you make an egg or a sperm. It's called nondisjunction. When it happens, it's no one's fault. Marriage between close relatives, like 1st cousins, is common in many places in the world, and trisomy 13 is just as rare there as it is everywhere else. ...Read more

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What is the average lifespan of someone with trisomy 13, patau syndrome?

What is the average lifespan of someone with trisomy 13, patau syndrome?

Lifespan: In my clinical experience of 31 years practicing neonatal medicine, i would have to answer your question with a vague response. This is because each affected child does not necessarily have the same degree of affliction. The literature on this tells us that 99.9% die before a year of age. I have not seen one survive longer than two months, and I have seen many. ...Read more

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Are there any specialized hospitals for trisomy 13 patients? Spealized drs?

Look here: Not sure where you live. Try this list. http://www.ds-health.com/clinics.htm. ...Read more

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Can radiation cause trisomy 13?

Can radiation cause trisomy 13?

Not to my knowledge: Trisomy is caused by a robertsonian translocation in the karyotype of one of the parents or by a meiotic nondisjunction event of a sperm or egg cell. 88% of time trisomy comes from nondisjunction in the maternal egg and 8% comes from nondisjunction in the paternal sperm. ...Read more

Prognosis (Definition)

The prognosis is the predicted outcome or "forecast" for a disease or process. It is only an estimate but is likely based on past experience or data taking into account the individual's overall health status. It may suggest progression of disease ...Read more


Dr. Karl Muench
23 doctors shared insights

Patau Syndrome (Definition)

Patau syndrome is the least common and most severe of the viable autosomal trisomies. Median survival is fewer than 3 days. First was identified as a chromosomal syndrome in 1960. Patau syndrome is caused by an extra ...Read more