Doctor insights on:
Prognosis Of Trisomy 13
Days/weeks.: Stillbirth (see picture) is very common. Of liveborns, 80% of affected infants die within the first month of life; only 5% survive the first six months. Severe intellectual disability, seizures, and failure to thrive are noticeable in survivors over 1 year of age. No interventions for fetal benefit are ethically justifiable during pregnancy (no cesarean section, no fetal monitoring indicated). ...Read more
Ordinary chromosomal traits require a pair of chromosomes to determine the traits. Occasionally, as a mistake in cellular division, there is a tripling of one of the chromosomes. When these occur, they usually cause unpleasant, and sometimes deadly conditions in the inheritor of these traits (e.g. Down's). Many we do not know about as they are ...Read more
Many: There are numerous disorders that can happen with abnormalities of chromosomes 10 and 13. Too many to list here. Trisomy 21 means the person has an extra chromosome 21 and this is more commonly known as Down's syndrome. There are many possible phenotypic findings with this disorder, again too many to list here including physical characteristics, heart , hearing, vision, skeletal, developmental.... ...Read more
Chromosome error: Humans have 23 pairs of chromosomes(c) making up our dna.When the egg or sperm form, the (c) pairs are supposed to split up with 1 (c) of each pair going to the egg or sperm.If the 13 (c) does not split & both go into an egg, fertilization will add a 3rd from dad & a trisomy 13 will begin to form. The imbalanced (c) causes malformations, miscarriage or early death. ...Read moreSee 1 more doctor answer
Lifespan: In my clinical experience of 31 years practicing neonatal medicine, i would have to answer your question with a vague response. This is because each affected child does not necessarily have the same degree of affliction. The literature on this tells us that 99.9% die before a year of age. I have not seen one survive longer than two months, and I have seen many. ...Read more
Chromosomal anomaly: A small percentage of people with trisomy 13 have an extra copy of chromosome 13 in only some of the body's cells. In these people, the condition is called mosaic trisomy 13. The severity of mosaic trisomy 13 depends on the type and number of cells that have the extra chromosome. The physical features of mosaic trisomy 13 are often milder than those of full trisomy 13. ...Read moreSee 1 more doctor answer
Realistic chance of survival for 5 year old with stage 4 neuroblastoma? Currently on 3rd of 6 rounds of chemo , will have stem cell transplant.
Around 30%: Neuroblastoma is mainly a childhood disease usually diagnosed at around 1 year, up to about 5 years. It is derived from the primitive cells of the adrenal gland and while appearing in retroperitoneum can be found in chest and head and neck, spreading to lungs and bone. The approach here is chemo, more becoming available followed by stem cell treatment. Today survival is around 30% for stage 4 ...Read moreSee 1 more doctor answer
Hx of 4 diagnosed chromosomal pregnancies in a row trisomy 22, 18, 13 & mono 21. I'm 39 yrs old. Is there hope of a normal pregnancy using my own eggs?
Hope yes, but..: Remember, the ancient greeks said that hope was the last evil in pandora's box.. Your history sounds horrible and I am very sorry. There is always a chance of normal pregnancy with your own eggs, however i would recommend genetic counseling and ivf with preimplantation genetic diagnosis in your case (or donor eggs). Take Folic Acid 1-5 mg daily and best of luck! ...Read more
Neither: Any defect like trisomy 13, that involves acquiring an extra chromosome, has nothing to do with dominant or recessive genes. It occurs when usually the egg carries 2 rather than 1 of the 13 chromosomes. Fertilization by a normal sperm with one of every chromosome creates an embryo with three # 13's.If the embryo survives pregnancy it emerges as a trisomy 13 infant with all the problems they have. ...Read more
What is longterm prognosis for grade 3, stage 1b, triple positive breast cancer, double mastectomy and 6 treatments of TCH with one year of herceptin, (trastuzumab)?
Not to my knowledge: Trisomy is caused by a robertsonian translocation in the karyotype of one of the parents or by a meiotic nondisjunction event of a sperm or egg cell. 88% of time trisomy comes from nondisjunction in the maternal egg and 8% comes from nondisjunction in the paternal sperm. ...Read more
Normal: These women appear no different from any other and have no special problems. ...Read more
Twin girls born at 24 weeks weighing less than 500 grams each . How high is the possibility of survival?
You'd be amazed...: The majority of 24 week infants now survive, especially if they make it through the first 48 hours of life. That's not to say they may not have significant problems with breathing, feeding, development, vision. You also don't say 24 weeks and how many days . 24 weeks 0 days is worse than 24 weeks 5 days - at that stage of the game, every extra day makes a difference. Continue hope, faith and pray. ...Read more
Friends mom was juts diagnosed with stage 3 aggressive multiple myloma at 58. What is the average lifespan after diagnosis of this?
Depends: Primary brain cancers aren't staged i-iv so you may be talking about a cancer from somewhere else that spread to the brain. Would also depend on how extensive the tumor is in the brain, if the primary cancer has been controlled, and if there are other sites where the cancer had spread. ...Read more
What is life expectancy of 49 yr old male with stage IV adenocarcinoma of lung? Receive chemo/avastin radiation last CT showed significant progression
Hard to say: Predicting how long someone will live with stage IV lung cancer is always difficult. You said that your disease had progressed. I assume that is on a pet/ct scan. It would depend on how much it's progressed. Unfortunately it may be as little as 8 mos. Or less. It depends on any underlying conditions conditions such as copd. I would strongly advise you to discuss this with your oncologist. ...Read more