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Doctor insights on: Progesterone Uterine Fibroma Myoma

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I've been taking progesterone for several months now. My uterine fibroma (myoma) is still there. Why?

I've been taking progesterone for several months now. My uterine fibroma (myoma) is still there. Why?

Switch treatment: Progesterone treatment for myoma is controversial. There is some evidence that Progesterone may actually even stimulate fibroid growth, contrary to anecdotal reports of treatment benefit by some clinicians. Ask your doctor about other treatments. Drugs that stop your ovaries from making estrogen & Progesterone have been shown to shrink, but not eradicate fibroids, for as long as you take them. ...Read more

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Dr. Scott Methven
114 doctors shared insights

Fibroma (Definition)

Fibroma is a term used to denote a benign growth composed of fibrous cells. They are often firm or hard in consistency and can have an appearance like a scar. Histopathologically, they are predominantly composed of a ...Read more


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How do surgeons remove multiple uterine fibromas with a laser?

How do surgeons remove multiple uterine fibromas with a laser?

Myomectomy: Lasers can be used in gyn surgery as a tool during myomectomy. That is the surgical removal of fibroid tumors from the uterus. A laser can be used as a cutting tool and also to vaporize lesions or small nodules. ...Read more

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Is slight uterine bleeding normal when you cut back or stop using estrogen/progesterone?

Is slight uterine bleeding  normal when you cut back or stop using estrogen/progesterone?

Maybe.: Bleeding occurs of the amount of progestin is lower than needed by the amount of estrogen. This is why i avoid combo-pills with both in a fixed dose of patch. It is quite controversial about hrt, but Medroxyprogesterone is not "heart healthy, " why estrogen is. Therefore I use natural progesterone. If your bleeding continues, check with your doctor. ...Read more

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Should I have uterine polyp removed 47years old, very low progesterone levels, short cycle

Should I have uterine polyp  removed 47years old, very low progesterone levels, short cycle

It : It depends on your symptoms and your biopsy results. If you have had a negative biopsy, then it depends on your symptoms, such as if you are having heavy bleeding or pain. Please discuss these issues with your gynecologist who diagnosed the polyp so that you can make an informed decision. ...Read more

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What causes uterine cramping after IVF progesterone?

What causes uterine cramping after IVF progesterone?

Not progesterone: Uterine cramping can happen for many reasons - you don't say where in the ivf process you are - but Progesterone does not cause cramping, if anything it tends to relax muscle. ...Read more

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Can uterine polyps go away with progesterone therapy?

No but: Progesterone will not make polyps go away. However they will oftentimes resolve on their own with no treatment and do not always require surgery. ...Read more

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Does long term use of estrogen and progesterone lower risk for uterine cancer?

Does long term use of estrogen and progesterone lower risk for uterine cancer?

When combined: It will lower risk if combined in an hormone replacement therapy(HRT) for applicable patients. Estrogen used alone for (HRT) in women who still have a uterus present can increase their risk of uterine cancer.(endometrial) when progesterone is not used. ...Read more

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How long does it take to thin uterine lining on prometrium (micronized progesterone)?

How long does it take to thin uterine lining on prometrium (micronized progesterone)?

10-14 days: It does depend on the situation. But usually daily use for 10-14 days is long enough to start noticing some effects. But this really depends on the reason for the thick lining. For example, women who are very heavy have conversion of precursor androgens into estrogen that takes place in their fat cells. This excess estrogen then continues to stimulate the uterine lining. So it may take longer. ...Read more

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When taking progesterone 200 mg a day every day doesn't stop uterine polyps then what ? all biopsy and d and c benign

When taking progesterone 200 mg a day every day doesn't stop uterine polyps then what ?  all biopsy and d and c benign

Hysteroscopy: It sounds like if you've had D&Cs and still have polyps that you might need a hysteroscopy where your GYN uses a small camera to go into the uterus and LOOK for the pesky polyp and removes it using a tiny grasper. It's a very simple procedure and can help when medications do not. This can sometimes be done in the office. ...Read more

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Is estrogel and progesterone dangerous if your mother died of uterine cancer ?

Is estrogel and progesterone dangerous if your mother died of uterine cancer ?

Probably not: Probably not but best to have a detailed conversation about your family history and other risk factors with your gynecologist. ...Read more

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If progesterone cream stopped uterine bleeding, does that rule out endometrial hyperplasia? Thank you!

If progesterone cream stopped uterine bleeding, does that rule out endometrial hyperplasia? Thank you!

Yes: i found a study that showed vaginal cream containing 100 mg of natural micronized progesterone reversed endometrial hyperplasia. Hope that helps. ...Read more

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So confused why prescribed prometrium (micronized progesterone) for just thick uterine lining if its used to thicken lining?

Let me help.: Prometrium (micronized progesterone) is a type of progesterone. Progesterone stabilizes the lining of the uterus and tells it not to get any thicker. When you stop taking the progesterone, a few days later the lining will come out like a period. It's actually the estrogen that makes the lining grow thicker and the Progesterone that stabilizes the lining. ...Read more

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Hysteroscopy 9/13 biopsy all nrml taking progesterone now have 2cm uterine polyp unlikely cancer or no?

Hysteroscopy 9/13 biopsy all nrml taking progesterone now have 2cm uterine polyp unlikely cancer or no?

Unlikely: all endometrial polyps should be sent to a pathologist for after ascertainment of whether or not there is a cancer in the polyp. This is highly unlikely if you are on progesterone, however the risk of cancer does increase with age. My suggestion would be to have the polyps removed. The procedure is low risk, would be happy to discuss further. ...Read more

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Was instructed to take Prometrium (micronized progesterone). But Doctor also says my uterine lining was very healthy n thick @ 9.5. if I don't need it why take it?

Clarification: When prescribed a new medication it is always good ask for clarification on the goals, duration of treatment, excepted outcomes and side effects. Without knowing more about your case we can not provide specific guidance but these are good questions to ask the prescribing doctor who knows all of the details ...Read more

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I am 60 and have been post-menopausal for 20 years.I've taken bhrt for most of that time.My uterine lining is thick (abt 3-5 cm) and I am to have a prometrium (micronized progesterone) sweeping. [rest of q in subsequent msg]?

I am 60 and have been post-menopausal for 20 years.I've taken bhrt for most of that time.My uterine lining is thick (abt 3-5 cm) and I am to have a prometrium (micronized progesterone) sweeping. [rest of q in subsequent msg]?

Uh oh: If your uterine lining is really 3-5 centimeters thick - you need to have some form of biopsy done (endometrial biopsy in the office) or d&c.The uterine lining of a postmenopausal women should be closer to 3 millimeters, and if it is 3cm, there is a very high chance of having endometrial cancer.I don't know what Prometrium (micronized progesterone) sweeping is, but if it is taking Prometrium (micronized progesterone) for 7d, to cause. It isn't enoug. ...Read more

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I don't even have any antibody and no uterine abnormality my progesterone level is also perfect. Miscarriages in 2 month twice. No heart beat detected?

I don't even have any antibody and no uterine abnormality my progesterone level is also perfect. Miscarriages in 2 month twice. No heart beat detected?

Two m.ds: two should an endocrinologist and gynae m.d at place like mayo or teaching center and need to ck all hormones , and work togather , put attention on fruits, nuts, flaxseed and good nutritin 8 hrs sleep give alcohol a breakmay be vitamine a day. lot of berries. ...Read more

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getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

 getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

Gyn follow up: I have noticed you’ve asked a few similar questions regarding this topic. Consider doing a virtual visit so that all of your questions can get answered at once and you can get a more in depth analysis of your specific questions. Endometrial ablation is one option to help prevent polyps. Most specialists do not consider the potential masking of endometrial cancer to be a reason to avoid ablation. ...Read more

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Recurring uterine polyps all biopsies show no hyperplasia/cancer on 200 mg prometrium (micronized progesterone) every day with no luck so now what ?

Recurring uterine polyps all biopsies show no hyperplasia/cancer on 200 mg prometrium (micronized progesterone) every day with no luck so now what ?

Depends on symptoms: if you have recurrent polyps that cause lot of bleeding, with negative work up for cancer, have you considered endometrial ablation? that may decrease the irregularities of bleeding and provide symptomatic relief Best Wishes Dr M ...Read more

Dr. Seth Derman
1,168 doctors shared insights

Progesterone (Definition)

Progesterone has been found to be helpful in preventing preterm birth in a patient who has a history of delivering babies too early. It can be given as vaginal suppositories. It is most often given as weekly ...Read more


Uterus (Definition)

The uterus is a muscular organ in a woman's pelvis where the the fertilized egg attaches ...Read more