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Doctor insights on: Progesterone Therapy Risks

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How effective is progesterone therapy?

How effective is progesterone therapy?

Controversial : There is little doubt that taking Progesterone supplementation helps ivf success rates. There is alo evidence that in certain circumstances it may reduce preterm birth. Although Progesterone has been used for other purposes in infertility and preventing miscarriage, its effectiveness is unproven. ...Read more

Dr. Seth Derman
1,129 doctors shared insights

Progesterone (Definition)

Progesterone has been found to be helpful in preventing preterm birth in a patient who has a history of delivering babies too early. It can be given as vaginal suppositories. It is most often given as weekly ...Read more


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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Can uterine polyps go away with progesterone therapy?

No but: Progesterone will not make polyps go away. However they will oftentimes resolve on their own with no treatment and do not always require surgery. ...Read more

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My period started during progesterone therapy. Is this normal?

My period started during progesterone therapy. Is this normal?

Common: It's common, but need more specs to say if it's 'normal.' for example if Progesterone is taken to start a late period is different than if you are ttc and taking Progesterone for luteal support before a pregnancy test. It is also important to distinguish start of a period while on Progesterone from vaginal bleeding due to other causes. ...Read more

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I have another question, i was told i had cysts on my ovaries by one doctor but i suffrred 3misscarriages and was told i needed progesterone therapy?

I have another question, i was told i had cysts on my ovaries by one doctor but i suffrred 3misscarriages and was told i needed progesterone therapy?

Unclear Question: If you are asking can you have cyst and have had the miscarriages the answer is yes. Theses are separate issues that can be related if you have a condition called polycystic ovarian syndrome. This can affect your fertility status and your ability to maintain a pregnancy. More info would be needed to understand the need for Progesterone therapy. Cyst can be treated w birth control. ...Read more

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getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

 getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

Gyn follow up: I have noticed you’ve asked a few similar questions regarding this topic. Consider doing a virtual visit so that all of your questions can get answered at once and you can get a more in depth analysis of your specific questions. Endometrial ablation is one option to help prevent polyps. Most specialists do not consider the potential masking of endometrial cancer to be a reason to avoid ablation. ...Read more

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My estrogen, progesterone & testosterone levels are extremely low- as is my dhea & vitamins d & b considering pellet therapy. Is this best? I'm 38.

My estrogen, progesterone & testosterone levels are extremely low- as is my dhea & vitamins d & b considering pellet therapy. Is this best? I'm 38.

NO cures: First see an endocrinologist to find out the cause of the low levels, if they are really low in a reputable lab. Bring your labs with you. Pellets, popular in australia, are used by too many ill trained people in the us. There are many other options to explore if you really are deficient. ...Read more

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Does hormone replacement therapy using estradiol and progesterone cause weight gain?

Does hormone replacement therapy using estradiol and progesterone cause weight gain?

No: Not consistently anyway. Women going through menopause often gain some weight, so it commonly gets blamed on hrt. ...Read more

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Should I take progesterone therapy for adenomyosis if I have a strong family history of stroke, breast cancer, and migraines with aura?

Should I take progesterone therapy for adenomyosis if I have a strong family history of stroke, breast cancer, and migraines with aura?

No: it realy depends on your plan to have children.if you no longer wishes to have children you should not take any risk with hormonal treatment,and choose surgical option.if you are planning to have more children,then you conservative,medical,hormonal treatment is the only option,in spite of your family history.discuss your options with your GYN. ...Read more

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