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Doctor insights on: Progesterone Therapy Risks

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How effective is progesterone therapy?

How effective is progesterone therapy?

Controversial : There is little doubt that taking Progesterone supplementation helps ivf success rates. There is alo evidence that in certain circumstances it may reduce preterm birth. Although Progesterone has been used for other purposes in infertility and preventing miscarriage, its effectiveness is unproven. ...Read more

Dr. Seth Derman
1,164 doctors shared insights

Progesterone (Definition)

Progesterone has been found to be helpful in preventing preterm birth in a patient who has a history of delivering babies too early. It can be given as vaginal suppositories. It is most often given as weekly ...Read more


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I'm on progesterone therapy. For 10 days, I take 10 mg pill. I accidentlly too one too many pills and wonder if that's why my period hasn't come on. ?

I'm on  progesterone therapy. For 10 days, I take 10 mg pill. I accidentlly too one too many pills and wonder if that's why my period hasn't come on. ?

Perhaps? unlikely: One pill of progesterone is unlikely to make any impact. Give it a few more days; seek your gynecologist's advice if your period does not start over the next 1 week. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Can uterine polyps go away with progesterone therapy?

No but: Progesterone will not make polyps go away. However they will oftentimes resolve on their own with no treatment and do not always require surgery. ...Read more

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My period started during progesterone therapy. Is this normal?

My period started during progesterone therapy. Is this normal?

Common: It's common, but need more specs to say if it's 'normal.' for example if Progesterone is taken to start a late period is different than if you are ttc and taking Progesterone for luteal support before a pregnancy test. It is also important to distinguish start of a period while on Progesterone from vaginal bleeding due to other causes. ...Read more

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I have another question, i was told i had cysts on my ovaries by one doctor but i suffrred 3misscarriages and was told i needed progesterone therapy?

I have another question, i was told i had cysts on my ovaries by one doctor but i suffrred 3misscarriages and was told i needed progesterone therapy?

Unclear Question: If you are asking can you have cyst and have had the miscarriages the answer is yes. Theses are separate issues that can be related if you have a condition called polycystic ovarian syndrome. This can affect your fertility status and your ability to maintain a pregnancy. More info would be needed to understand the need for Progesterone therapy. Cyst can be treated w birth control. ...Read more

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getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

 getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

Gyn follow up: I have noticed you’ve asked a few similar questions regarding this topic. Consider doing a virtual visit so that all of your questions can get answered at once and you can get a more in depth analysis of your specific questions. Endometrial ablation is one option to help prevent polyps. Most specialists do not consider the potential masking of endometrial cancer to be a reason to avoid ablation. ...Read more

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My estrogen, progesterone & testosterone levels are extremely low- as is my dhea & vitamins d & b considering pellet therapy. Is this best? I'm 38.

My estrogen, progesterone & testosterone levels are extremely low- as is my dhea & vitamins d & b considering pellet therapy. Is this best? I'm 38.

NO cures: First see an endocrinologist to find out the cause of the low levels, if they are really low in a reputable lab. Bring your labs with you. Pellets, popular in australia, are used by too many ill trained people in the us. There are many other options to explore if you really are deficient. ...Read more

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Does hormone replacement therapy using estradiol and progesterone cause weight gain?

Does hormone replacement therapy using estradiol and progesterone cause weight gain?

No: Not consistently anyway. Women going through menopause often gain some weight, so it commonly gets blamed on hrt. ...Read more

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Should I take progesterone therapy for adenomyosis if I have a strong family history of stroke, breast cancer, and migraines with aura?

Should I take progesterone therapy for adenomyosis if I have a strong family history of stroke, breast cancer, and migraines with aura?

No: it realy depends on your plan to have children.if you no longer wishes to have children you should not take any risk with hormonal treatment,and choose surgical option.if you are planning to have more children,then you conservative,medical,hormonal treatment is the only option,in spite of your family history.discuss your options with your GYN. ...Read more

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My gym said my endometrial line was 10mm in february and the treatment i was given was progesterone but still no improvement. What can I do?

My gym said my endometrial line was 10mm in february and the treatment i was given was progesterone but  still no improvement. What can I do?

Need info: This is not enough information to answer you. 1-how old are you 2-are you trying to get pregnant 3-are you having bleeding problems 4-are you menopausal. ...Read more

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I did my progesterone test at day 4 aftet et in my IVF treatment. They were just 1.7. Is it fine or something to worry about. Please tell me. ?

I did my progesterone test at day 4 aftet et in my IVF treatment. They were just 1.7. Is it fine or something to worry about. Please tell me. ?

IVF Progesterone: Progesterone (p4) levels after ivf are often confusing. We often use vaginal Progesterone which goes directly into the uterus and then does not show up in the blood stream. Intramuscular p4 gives great blood levels but the injections hurt. We usually do not measure p4 levels when we use vaginal p4 because the numbers do not help and only cause worry - particularly if you read the internet :). ...Read more

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27, 2 children-ttc. Low progesterone. Referred to reproductive endocrinology. Curious what treatment plan might be? Help please

27, 2 children-ttc. Low progesterone. Referred to reproductive endocrinology. Curious what treatment plan might be? Help please

Studies: A low Progesterone suggests an error in ovulation. Since you have 2 children, this is likely new and temporary. If the timing of the test is appropriate and the defect persists, ovulatory stimulating medicine should help. ...Read more

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Ttc-progesterone low. Dr referring me to a specialist. What are treatment for this? Is this uncommon? 27 yrs old with a 7 and 5 year old.

Ttc-progesterone low. Dr referring me to a specialist.  What are treatment for this? Is this uncommon? 27 yrs old with a 7 and 5 year old.

When?: Depends on when during cycle it is measured. Prior to ovulation levels are low, typically less than 1 to 2 ng/ml. Soon after ovulation levels will be greater than 2 ng/ml and up to 25, 30 or more. In the second half of the cycle (luteal phase) Progesterone is secreted in pulses and levels vary widely; i therefore think the idea of 'normal' doesn't help much. ...Read more

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What causes a female to have low e2 and progesterone? What is the treatment testosterone normal. E2 less than 21 progesterone .6 on day 2 of cycle sm

What causes a female to have low e2 and progesterone? What is the treatment testosterone normal. E2 less than 21 progesterone .6  on day 2 of cycle sm

Normal: The levels of estrogen and Progesterone you wrote are very normal for a cycle day 2. Your Estradiol will slowly rise to about 150-250pg around the time of ovulation and your Progesterone doesn't increase until after you ovulate. If your cycles are regular, then those numbers are ok. ...Read more

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What is the side effect of progesterone treatment in a post-menopausal woman with endometrial thickness of 11mm?

What is the side effect of progesterone treatment in a post-menopausal woman with endometrial thickness of 11mm?

Need biopsy: A uterine lining, called "endometrial stripe" or "thickness", of 11 mm measured on ultrasound is not normal after menopause. Experts recommend biopsy for stripe >5 mm. Thickening can be sign of xs estrogen effect on uterus.Progesterone can reverse this & prevent uterine cancer. Side effects of Progesterone can be weight gain, mood swings , skin changes & unknown effects on breast health. ...Read more

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