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Doctor insights on: Progesterone Therapy Risks

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Estrogen replacement therapy effects on health?

Estrogen replacement therapy effects on health?

Depends on age: Early estrogen replacement rx (hrt) is of major value in women with either surgical menopause or early menopause in diminishing the likelihood of heart disease. It diminishes the chance for osteoporosis and colon cancer. It makes a females sexual-life longer. However, in older females with metabolic syndrome, or who have been off or never on hormones, a serm like Evista (raloxifene) may be better option. ...Read more

Dr. Seth Derman
1,174 doctors shared insights

Progesterone (Definition)

Progesterone has been found to be helpful in preventing preterm birth in a patient who has a history of delivering babies too early. It can be given as vaginal suppositories. It is most often given as weekly ...Read more


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Does hormone replacement therapy have significant risks?

Does hormone replacement therapy have significant risks?

It can: If not monitored. Estradiol and estriol levels are much higher in ovulating women & pregnant women, respectively. Birth control estrogen is 5x more potent than the estrogen used in hrt and carries risks of blood clots, heart attack etc. Estrone levels are high in overweight women who carry the same risks. Hrt that is not converted to estrone is the key, in my opinion. ...Read more

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Is hormone replacement therapy safe?

Is hormone replacement therapy safe?

Can be, depends: Hormones are powerful things! they should be prescribed by licensed practioners acting within their scope of practice! they can be helpful for hot flashes, painful sex, night sweats, and bone health. Risks: blood clots, stroke, heart attacks. This is a personal decision between you and your doctor with a specific plan for results and followup. Fda approved=bioidentical! ...Read more

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Does hormone replacement therapy increase your chances for breast cancer expotentionally?

Does hormone replacement therapy increase your chances for breast cancer expotentionally?

Not exponentially: Data from the whi (women's health initiative) study show that estrogen alone does not significantly increase the risk of breast cancer, especially if started within 5 years of menopause. However, estrogen + Progesterone (needed when women still have a uterus to prevent uterine cancer) increases the risk of breast cancer to about 2x the baseline risk. Progesterone appears to be the "bad guy". ...Read more

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What are the risks with herceptin (trastuzumab) therapy?

What are the risks with herceptin (trastuzumab) therapy?

Heart failure: About 4% of women treated with Herceptin (trastuzumab) develop some weakness in their heart as measured by a muga test. This decrease in heart function is reversible when the drug is stopped. Other side effects of Herceptin (trastuzumab) can include allergic reaction, fatigue, headache and diarrhea. Most of my patients have no side effects! ...Read more

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Is biochemical hormone replacement therapy effective?

Is biochemical hormone replacement therapy effective?

Bioidenticals: Bioidentical hormone replacement therapy (bhrt) has gained popularity as a strategy for keeping hormones balanced beyond the body's ability to supply us. Bioidentical hormones are different from synthetic hormones because they are derived from sources such as soy and yams, that are naturally occurring. These hormones have the same chemical structure as the hormones produces by our bodies. ...Read more

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On testosterone replacement therapy. Good or bad in lieu of jama nov 5 article citing increased cardiac event risk. Trt benefits outweigh risks?

On testosterone replacement therapy. Good or bad in lieu of jama nov 5 article citing increased cardiac event risk. Trt benefits outweigh risks?

Unknown: As is indicated in the article, we need randomized, prospective studies to truly know the risks and benefits of testosterone treatment. The real problem is that as many as 80% of men who are on testosterone, were placed on it for inappropriate reasons, including inadequate testing or misinterpretation of results.Mother nature has a way of striking back when we do inappropriate things to our body. ...Read more

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Are women using hormone replacement therapy at risk for other health conditions?

Are women using hormone replacement therapy at risk for other health conditions?

Yes: The estrogen hormone increases the risk of deep vein clots, a dangerous condition, to about twice the baseline rate. It also increases the risk of cancer of the uterus unless combined with a Progesterone hormone. This combination protects the uterus but somewhat increases the risk of breast cancer, an effect not seen with estrogen alone. Hormone replacement also increases the risk of bleeding. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Does hormone replacement therapy using estradiol and progesterone cause weight gain?

Does hormone replacement therapy using estradiol and progesterone cause weight gain?

No: Not consistently anyway. Women going through menopause often gain some weight, so it commonly gets blamed on hrt. ...Read more

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Can testosterone therapy increase a woman's risk of aggression?

Can testosterone therapy increase a woman's risk of aggression?

Yes: In both men & women, testosterone therapy in excess can increase risk of aggression. Typically, if someone is good-natured, testosterone in excess won't change their temperament. But in those who are already nasty to begin with, it's been said that too much testosterone can make their disposition worse. Notice i didn't list a specific level as everyone has an individual threshold. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer?

No: Studies show that adding tamoxifen to an aromatase inhibitor (what i assume you mean by "hormonal therapy") was not better than either drug alone. ...Read more

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Does hormone replacement therapy prevent osteoporosis?

Does hormone replacement therapy prevent osteoporosis?

Yes, an option: There are many things you can do to avoid osteoporosis. Things you can't change: your family history, race, aging. Things you can change: get adequate calcium: 1500 mg per day, vit d 2000 iu per day, physical activity: 150 minutes per week (or 50 jumps per day), have normal tsh, get regular screening, and know your personal risk factors. Have a frax score done to help you decide what to do. ...Read more

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What are the risks of estrogen hormone treatment?

What are the risks of estrogen hormone treatment?

Estrogen related: Multiple possible risks like from the estrogen stroke blood clots cancer of endometrium or breast always have proper assessment by your gyn regarding risks before starting therapy. ...Read more

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Estrogen in contraception pills or menopausal hormone therapy have same effect?

Mostly yes: Pharmacologically yes, although the amount of estrogen in hrt is usually lower than in ocp; therefore symptomatically it might be different. Some hrt also contains different estrogen types, for example conjugated equine estrogens, but the basic effect is still similar. ...Read more

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How safe is hormone replacement therapy if family history breast cancer?

How safe is hormone replacement therapy if family history breast cancer?

Varies: If a first order relative (mother, sister, daughter) has bc i would take ert only briefly and then only for severe symptoms. Remember that we try to prevent breast cancer by prescribing tamoxifen - which blocks estrogen. Adding ert definitely increases risk, somewhat, so you have to balance risks/benefits. Some women are miserable without it - and a short course may be appropriate for them. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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