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Doctor insights on: Progesterone Therapy Risks

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Estrogen replacement therapy effects on health?

Estrogen replacement therapy effects on health?

Depends on age: Early estrogen replacement rx (hrt) is of major value in women with either surgical menopause or early menopause in diminishing the likelihood of heart disease. It diminishes the chance for osteoporosis and colon cancer. It makes a females sexual-life longer. However, in older females with metabolic syndrome, or who have been off or never on hormones, a serm like Evista (raloxifene) may be better option. ...Read more

Dr. Seth Derman
1,179 doctors shared insights

Progesterone (Definition)

Progesterone has been found to be helpful in preventing preterm birth in a patient who has a history of delivering babies too early. It can be given as vaginal suppositories. It is most often given as weekly ...Read more


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Does hormone replacement therapy have significant risks?

Does hormone replacement therapy have significant risks?

It can: If not monitored. Estradiol and estriol levels are much higher in ovulating women & pregnant women, respectively. Birth control estrogen is 5x more potent than the estrogen used in hrt and carries risks of blood clots, heart attack etc. Estrone levels are high in overweight women who carry the same risks. Hrt that is not converted to estrone is the key, in my opinion. ...Read more

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Is hormone replacement therapy safe?

Is hormone replacement therapy safe?

Can be, depends: Hormones are powerful things! they should be prescribed by licensed practioners acting within their scope of practice! they can be helpful for hot flashes, painful sex, night sweats, and bone health. Risks: blood clots, stroke, heart attacks. This is a personal decision between you and your doctor with a specific plan for results and followup. Fda approved=bioidentical! ...Read more

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Does hormone replacement therapy increase your chances for breast cancer expotentionally?

Does hormone replacement therapy increase your chances for breast cancer expotentionally?

Not exponentially: Data from the whi (women's health initiative) study show that estrogen alone does not significantly increase the risk of breast cancer, especially if started within 5 years of menopause. However, estrogen + Progesterone (needed when women still have a uterus to prevent uterine cancer) increases the risk of breast cancer to about 2x the baseline risk. Progesterone appears to be the "bad guy". ...Read more

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What are the risks with herceptin (trastuzumab) therapy?

What are the risks with herceptin (trastuzumab) therapy?

Heart failure: About 4% of women treated with Herceptin (trastuzumab) develop some weakness in their heart as measured by a muga test. This decrease in heart function is reversible when the drug is stopped. Other side effects of Herceptin (trastuzumab) can include allergic reaction, fatigue, headache and diarrhea. Most of my patients have no side effects! ...Read more

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Is biochemical hormone replacement therapy effective?

Is biochemical hormone replacement therapy effective?

Bioidenticals: Bioidentical hormone replacement therapy (bhrt) has gained popularity as a strategy for keeping hormones balanced beyond the body's ability to supply us. Bioidentical hormones are different from synthetic hormones because they are derived from sources such as soy and yams, that are naturally occurring. These hormones have the same chemical structure as the hormones produces by our bodies. ...Read more

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On testosterone replacement therapy. Good or bad in lieu of jama nov 5 article citing increased cardiac event risk. Trt benefits outweigh risks?

On testosterone replacement therapy. Good or bad in lieu of jama nov 5 article citing increased cardiac event risk. Trt benefits outweigh risks?

Unknown: As is indicated in the article, we need randomized, prospective studies to truly know the risks and benefits of testosterone treatment. The real problem is that as many as 80% of men who are on testosterone, were placed on it for inappropriate reasons, including inadequate testing or misinterpretation of results.Mother nature has a way of striking back when we do inappropriate things to our body. ...Read more

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Are women using hormone replacement therapy at risk for other health conditions?

Are women using hormone replacement therapy at risk for other health conditions?

Yes: The estrogen hormone increases the risk of deep vein clots, a dangerous condition, to about twice the baseline rate. It also increases the risk of cancer of the uterus unless combined with a Progesterone hormone. This combination protects the uterus but somewhat increases the risk of breast cancer, an effect not seen with estrogen alone. Hormone replacement also increases the risk of bleeding. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Does hormone replacement therapy using estradiol and progesterone cause weight gain?

Does hormone replacement therapy using estradiol and progesterone cause weight gain?

No: Not consistently anyway. Women going through menopause often gain some weight, so it commonly gets blamed on hrt. ...Read more

Dr. Alvin Lin Dr. Lin
4 doctors agreed:
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Can testosterone therapy increase a woman's risk of aggression?

Dr. Alvin Lin Dr. Lin
4 doctors agreed:
Can testosterone therapy increase a woman's risk of aggression?

Yes: In both men & women, testosterone therapy in excess can increase risk of aggression. Typically, if someone is good-natured, testosterone in excess won't change their temperament. But in those who are already nasty to begin with, it's been said that too much testosterone can make their disposition worse. Notice i didn't list a specific level as everyone has an individual threshold. ...Read more

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Is combined tamoxifen plus hormonal therapy better for breast cancer?

No: Studies show that adding tamoxifen to an aromatase inhibitor (what i assume you mean by "hormonal therapy") was not better than either drug alone. ...Read more

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Does hormone replacement therapy prevent osteoporosis?

Does hormone replacement therapy prevent osteoporosis?

Yes, an option: There are many things you can do to avoid osteoporosis. Things you can't change: your family history, race, aging. Things you can change: get adequate calcium: 1500 mg per day, vit d 2000 iu per day, physical activity: 150 minutes per week (or 50 jumps per day), have normal tsh, get regular screening, and know your personal risk factors. Have a frax score done to help you decide what to do. ...Read more

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What are the risks of estrogen hormone treatment?

What are the risks of estrogen hormone treatment?

Estrogen related: Multiple possible risks like from the estrogen stroke blood clots cancer of endometrium or breast always have proper assessment by your gyn regarding risks before starting therapy. ...Read more

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Estrogen in contraception pills or menopausal hormone therapy have same effect?

Mostly yes: Pharmacologically yes, although the amount of estrogen in hrt is usually lower than in ocp; therefore symptomatically it might be different. Some hrt also contains different estrogen types, for example conjugated equine estrogens, but the basic effect is still similar. ...Read more

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How safe is hormone replacement therapy if family history breast cancer?

How safe is hormone replacement therapy if family history breast cancer?

Varies: If a first order relative (mother, sister, daughter) has bc i would take ert only briefly and then only for severe symptoms. Remember that we try to prevent breast cancer by prescribing tamoxifen - which blocks estrogen. Adding ert definitely increases risk, somewhat, so you have to balance risks/benefits. Some women are miserable without it - and a short course may be appropriate for them. ...Read more

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Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Tamoxifen is given to breast cancer patients to suppress estrogen or both estrogen & progesterone?

Estrogen: Tamoxifen is given to individuals with specific breast cancers that are driven to grow by the presence of estrogen receptors. Tamoxifen interferes with the activity of estrogen in the breast, preventing cancer growth. The role of Progesterone receptors is unclear, though Progesterone receptors in breast cancer are generally associated with estrogen receptors, making tamoxifen an effective therapy. ...Read more

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How effective is progesterone therapy?

How effective is progesterone therapy?

Controversial : There is little doubt that taking Progesterone supplementation helps ivf success rates. There is alo evidence that in certain circumstances it may reduce preterm birth. Although Progesterone has been used for other purposes in infertility and preventing miscarriage, its effectiveness is unproven. ...Read more

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I'm on progesterone therapy. For 10 days, I take 10 mg pill. I accidentlly too one too many pills and wonder if that's why my period hasn't come on. ?

I'm on  progesterone therapy. For 10 days, I take 10 mg pill. I accidentlly too one too many pills and wonder if that's why my period hasn't come on. ?

Perhaps? unlikely: One pill of progesterone is unlikely to make any impact. Give it a few more days; seek your gynecologist's advice if your period does not start over the next 1 week. ...Read more

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Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual: Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. ...Read more

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Can uterine polyps go away with progesterone therapy?

No but: Progesterone will not make polyps go away. However they will oftentimes resolve on their own with no treatment and do not always require surgery. ...Read more

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My period started during progesterone therapy. Is this normal?

My period started during progesterone therapy. Is this normal?

Common: It's common, but need more specs to say if it's 'normal.' for example if Progesterone is taken to start a late period is different than if you are ttc and taking Progesterone for luteal support before a pregnancy test. It is also important to distinguish start of a period while on Progesterone from vaginal bleeding due to other causes. ...Read more

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I have another question, i was told i had cysts on my ovaries by one doctor but i suffrred 3misscarriages and was told i needed progesterone therapy?

I have another question, i was told i had cysts on my ovaries by one doctor but i suffrred 3misscarriages and was told i needed progesterone therapy?

Unclear Question: If you are asking can you have cyst and have had the miscarriages the answer is yes. Theses are separate issues that can be related if you have a condition called polycystic ovarian syndrome. This can affect your fertility status and your ability to maintain a pregnancy. More info would be needed to understand the need for Progesterone therapy. Cyst can be treated w birth control. ...Read more

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getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

 getting uterine polyps despite progesterone therapy no hyperplasia/cancer how do I stop the growth read ablation can mask if cancer develops?

Gyn follow up: I have noticed you’ve asked a few similar questions regarding this topic. Consider doing a virtual visit so that all of your questions can get answered at once and you can get a more in depth analysis of your specific questions. Endometrial ablation is one option to help prevent polyps. Most specialists do not consider the potential masking of endometrial cancer to be a reason to avoid ablation. ...Read more

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My estrogen, progesterone & testosterone levels are extremely low- as is my dhea & vitamins d & b considering pellet therapy. Is this best? I'm 38.

My estrogen, progesterone & testosterone levels are extremely low- as is my dhea & vitamins d & b considering pellet therapy. Is this best? I'm 38.

NO cures: First see an endocrinologist to find out the cause of the low levels, if they are really low in a reputable lab. Bring your labs with you. Pellets, popular in australia, are used by too many ill trained people in the us. There are many other options to explore if you really are deficient. ...Read more

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Does hormone replacement therapy using estradiol and progesterone cause weight gain?

No: Not consistently anyway. Women going through menopause often gain some weight, so it commonly gets blamed on hrt. ...Read more

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Should I take progesterone therapy for adenomyosis if I have a strong family history of stroke, breast cancer, and migraines with aura?

Should I take progesterone therapy for adenomyosis if I have a strong family history of stroke, breast cancer, and migraines with aura?

No: it realy depends on your plan to have children.if you no longer wishes to have children you should not take any risk with hormonal treatment,and choose surgical option.if you are planning to have more children,then you conservative,medical,hormonal treatment is the only option,in spite of your family history.discuss your options with your GYN. ...Read more

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My gym said my endometrial line was 10mm in february and the treatment i was given was progesterone but still no improvement. What can I do?

My gym said my endometrial line was 10mm in february and the treatment i was given was progesterone but  still no improvement. What can I do?

Need info: This is not enough information to answer you. 1-how old are you 2-are you trying to get pregnant 3-are you having bleeding problems 4-are you menopausal. ...Read more

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I did my progesterone test at day 4 aftet et in my IVF treatment. They were just 1.7. Is it fine or something to worry about. Please tell me. ?

I did my progesterone test at day 4 aftet et in my IVF treatment. They were just 1.7. Is it fine or something to worry about. Please tell me. ?

IVF Progesterone: Progesterone (p4) levels after ivf are often confusing. We often use vaginal Progesterone which goes directly into the uterus and then does not show up in the blood stream. Intramuscular p4 gives great blood levels but the injections hurt. We usually do not measure p4 levels when we use vaginal p4 because the numbers do not help and only cause worry - particularly if you read the internet :). ...Read more

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27, 2 children-ttc. Low progesterone. Referred to reproductive endocrinology. Curious what treatment plan might be? Help please

27, 2 children-ttc. Low progesterone. Referred to reproductive endocrinology. Curious what treatment plan might be? Help please

Studies: A low Progesterone suggests an error in ovulation. Since you have 2 children, this is likely new and temporary. If the timing of the test is appropriate and the defect persists, ovulatory stimulating medicine should help. ...Read more

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Ttc-progesterone low. Dr referring me to a specialist. What are treatment for this? Is this uncommon? 27 yrs old with a 7 and 5 year old.

Ttc-progesterone low. Dr referring me to a specialist.  What are treatment for this? Is this uncommon? 27 yrs old with a 7 and 5 year old.

When?: Depends on when during cycle it is measured. Prior to ovulation levels are low, typically less than 1 to 2 ng/ml. Soon after ovulation levels will be greater than 2 ng/ml and up to 25, 30 or more. In the second half of the cycle (luteal phase) Progesterone is secreted in pulses and levels vary widely; i therefore think the idea of 'normal' doesn't help much. ...Read more

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What causes a female to have low e2 and progesterone? What is the treatment testosterone normal. E2 less than 21 progesterone .6 on day 2 of cycle sm

Normal: The levels of estrogen and Progesterone you wrote are very normal for a cycle day 2. Your Estradiol will slowly rise to about 150-250pg around the time of ovulation and your Progesterone doesn't increase until after you ovulate. If your cycles are regular, then those numbers are ok. ...Read more

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What is the side effect of progesterone treatment in a post-menopausal woman with endometrial thickness of 11mm?

What is the side effect of progesterone treatment in a post-menopausal woman with endometrial thickness of 11mm?

Need biopsy: A uterine lining, called "endometrial stripe" or "thickness", of 11 mm measured on ultrasound is not normal after menopause. Experts recommend biopsy for stripe >5 mm. Thickening can be sign of xs estrogen effect on uterus.Progesterone can reverse this & prevent uterine cancer. Side effects of Progesterone can be weight gain, mood swings , skin changes & unknown effects on breast health. ...Read more

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