Doctor insights on:
Once the corpus: Luteum (maturing egg) starts producing estrogen/progesterone, it feedbacks to the hypothalamus and pituitary gland to inhibit gnrh/lh/fsh production. Clomid (clomiphene) selectively inhibits the estrogen receptor in the hypothalmus which 'tricks' the body to release more fsh, which inturn causes growth of more ovarian follicles, and subsequently rupture of follicles resulting in ovulation to increase fertility. ...Read more
Interesting question: Nocturnal secretion of melatonin has been shown to affect secretion of prolactin. To my knowledge melatonin can exacerbate mild hyperprolactinemia. The relationship between Progesterone and prolactin i think is more unclear. We know thatprogesterone can affect prolactin in various ways. I'm curious to know in what context you would like to know the answer to this question? ...Read more
When prometrium (micronized progesterone) stimulates instead of sedates a perimenopausal woman what should be taken? Estrogen in combo with prometrium (micronized progesterone)?
Go see your doctor: While our impression of estrogen for perimenopausal women has changed dramatically over the last decade, it still should be used for right reason, and sedation is not one of them. So go see your prescribing doctor & tell her/him about your side effects so that s/he can offer you some alternatives (rather than just throw more medications at you). ...Read more
Pcos woman on clomid (clomiphene) ,then hcg injection is taken to trigger ovulation,what is required thickness of uterus before triggering ovulation?
Yes: Prometrium (micronized progesterone) doe not inhibit your own ovulation. And it is safe to take in pregnancy so that is why it is a nice medicine. I assume you are taking it to regulate your periods. But since it is generally a low does it wont usually suppress your own body from ovulating. ...Read more
2nd cycle clomid (clomiphene). Blood test 7days after HCG trigger shot shows:
Estradiol 807 Pmol/l
LH 21.48 Miu/ml
Progesterone 89.57 Nmol/l
Does this look good?
Levels are good: These look great, but be aware that does not predict "yes" or "no" this early. Good luck this cycle. ...Read more
Clomid (clomiphene) is an estro receptor.Brain needs estrogen surge to release lh.Which means ppl on Clomid (clomiphene) don't have LH surge?How egg burst out?
Got confused?: You are getting yourself confused. Clomid (clomiphene) is not an 'estro receptor' at all; it is mainly an estrogen receptor antagonist, but it has pro-estrogenic actions in some tissues and anti-estrogenic actions in others. Women on Clomiphene do mostly have an lh surge; not surging means the Clomiphene dose was likely too low. ...Read more
Yes: After taking Clomid (clomiphene) fsh levels may rise - this is the basis of the Clomid (clomiphene) challenge test (cct, also known as the ccct) which is a test of ovarian reserve or 'egg supply'. For this test you get an fsh level and Estradiol blood test on day 2 or 3, take 100 mg or two pills of Clomid (clomiphene) a day from days 5 to 9, then repeat the fsh test on day 10. Clomid (clomiphene) does not affect day 2 or 3 fsh levels though. ...Read more
Yes: Any of these hormones can be affected by exercise. What matters most is the amount of fat you have in your body, because fat stores estrogen, which can affect the signaling for ovulation in your body, which can really affect the amount of progesterone that would be found on a blood test. ...Read more
When adding estrogen to prometrium (micronized progesterone) for perimenopausal relief how is amt. Determined?
Starting dose: Most people will use 1-2 mg which are the lowest doses for effectiveness, sometime we go higher if symptoms are persistant. ...Read more
Clomid (clomiphene) help to increase FSH and LH to trigger ovulation, FSH and LH produce estrogen for lining , but why some drs say Clomid (clomiphene) will thin lining?
Antiestrogen: Clomid (clomiphene) works by blocking estrogen in your brain and pituitary gland. This makes the hormones rise which stimulate your eggs to grow. Unfortunately, it also blocks estrogen at the cervix and at your uterine lining. This can harm cervical mucus and make your uterus less receptive. ...Read more