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Doctor insights on: Progeria

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Dr. Elizabeth Guardiani
43 doctors shared insights

Progeria (Overview)

Progeria is a rare hereditary condition affecting the blood vessels, skin and musculoskeletal system that creates the impression of accelerated aging. Some aging processes are truly accelerated such as atherosclerosis of the coronary and carotid arteries, resulting early death. Most of the other illnesses of aging such as cancer, cataracts, and dementia do not occur but deposition of a substance associated with aging, liposuction, in vital organs leads to impairment of the liver, heart, adrenal glands, brain and skeletal system. Another protein, progeria, leads to defective DNA expression and repair. This protein also enhances the development of atherosclerosis. Children with Progeria have brittle bones, pathological fractures, feeding problems, dental abnormalities, hearing loss, growth failure, hairless, and clotting problems. Characteristic facial features are described.


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I want to know my options for treating progeria?

I want to know my options for treating progeria?

Become informed: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care.They can also help you find support groups & other parents in the same situation. ...Read more

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Dr. Elizabeth Guardiani
43 doctors shared insights

Progeria (Overview)

Progeria is a rare hereditary condition affecting the blood vessels, skin and musculoskeletal system that creates the impression of accelerated aging. Some aging processes are truly accelerated such as atherosclerosis of the coronary and carotid arteries, resulting early death. Most of the other illnesses of aging such as cancer, cataracts, and dementia do not occur but deposition of a substance associated with aging, liposuction, in vital organs leads to impairment of the liver, heart, adrenal glands, brain and skeletal system. Another protein, progeria, leads to defective DNA expression and repair. This protein also enhances the development of atherosclerosis. Children with Progeria have brittle bones, pathological fractures, feeding problems, dental abnormalities, hearing loss, growth failure, hairless, and clotting problems. Characteristic facial features are described.


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How exactly does progeria cause heart disease?

How exactly does progeria cause heart disease?

Abnormal metabolism: The accelerated aging syndrome known as progeria truly accelerates the patients aging and illness profile.Their metabolism is marked by the same abnormalities in cholesterol and fat metabolism in childhood as that seen in adult stroke and heart attack victims.Most succumb to complications of coronary heart disease as early as their teens. ...Read more

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What are the symptoms of progeria?

Resources: Please check with the geneticist involved in your child's care. Also, the following website may be useful http://www.Progeriaresearch.Org/progeria_101.Html. ...Read more

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What are the tests for progeria?

What are the tests for progeria?

See below: The gene responsible for progeria has been identified (lamin a) in april 2003. A blood test can now be performed progeria is due to a point mutation in this gene. It is not usually passed down in families. The gene change is a chance, rare occurrence. ...Read more

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What is the cause of progeria?

What is the cause of progeria?

Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists.Most don't survive their teens. ...Read more

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What is progeria and how is it treated?

What is progeria and how is it treated?

Supportive care: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care.They can also help you find support groups & other parents in the same situation. ...Read more

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What is the cause, symptoms, treatment of progeria?

What is the cause, symptoms, treatment of progeria?

Supportive care: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks ; provide guidence for your local source of care.They can also help you find support groups ; other parents in the same situation. ...Read more

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It happens that a cure for progeria syndrome lead to the "fountain of youth"?

Neither are likely: Given that progeria is so rare & hard to study, the likelihood of some treatment to reverse the metabolic consequence of this disease is remote. If it were, it would simply bring the kid up to the longevity of normal humans. ...Read more

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What is the genetic disorder progeria caused by? Is it a simple recessive trait?

What is the genetic disorder progeria caused by?  Is it a simple recessive trait?

Two likely forms: Progeria syndrome is considered a sporadic (new mutation) phenomenon that has few prenatal indicators. At an average birth wt of 6lb (2.7kg), the relatively small size during gestation is not specific to this disorder. There are rare instances of siblings to normal parents, showing that an autosomal recessive form exists.Most begin to show signs by 6-18mo. ...Read more