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Doctor insights on: Progeria

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Dr. Elizabeth Guardiani
44 Doctors shared insights

Progeria (Overview)

A rare hereditary condition affecting the blood vessels, skin and musculoskeletal system that creates the impression of accelerated aging. Some aging processes are truly accelerated such as atherosclerosis of the coronary and carotid arteries, resulting early death. Most of the other illnesses of aging such as cancer, cataracts, and dementia do not occur but deposition of a substance associated with aging, liposuction, in vital organs leads to impairment of the liver, heart, adrenal glands, brain and skeletal system. Another protein, progeria, leads to defective DNA expression and repair. This protein also enhances the development of atherosclerosis. Children with progeria have brittle bones, pathological fractures, feeding problems, dental abnormalities, hearing loss, growth failure, hairless, and clotting problems.


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I want to know my options for treating progeria?

I want to know my options for treating progeria?

Become informed: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

Dr. Elizabeth Guardiani
44 Doctors shared insights

Progeria (Overview)

A rare hereditary condition affecting the blood vessels, skin and musculoskeletal system that creates the impression of accelerated aging. Some aging processes are truly accelerated such as atherosclerosis of the coronary and carotid arteries, resulting early death. Most of the other illnesses of aging such as cancer, cataracts, and dementia do not occur but deposition of a substance associated with aging, liposuction, in vital organs leads to impairment of the liver, heart, adrenal glands, brain and skeletal system. Another protein, progeria, leads to defective DNA expression and repair. This protein also enhances the development of atherosclerosis. Children with progeria have brittle bones, pathological fractures, feeding problems, dental abnormalities, hearing loss, growth failure, hairless, and clotting problems.


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How exactly does progeria cause heart disease?

How exactly does progeria cause heart disease?

Abnormal metabolism: The accelerated aging syndrome known as progeria truly accelerates the patients aging and illness profile. Their metabolism is marked by the same abnormalities in cholesterol and fat metabolism in childhood as that seen in adult stroke and heart attack victims. Most succumb to complications of coronary heart disease as early as their teens. ...Read more

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What are the symptoms of progeria?

Resources: Please check with the geneticist involved in your child's care. Also, the following website may be useful http://www. Progeriaresearch. Org/progeria_101.Html. ...Read more

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What are the tests for progeria?

What are the tests for progeria?

See below: The gene responsible for progeria has been identified (lamin a) in april 2003. A blood test can now be performed progeria is due to a point mutation in this gene. It is not usually passed down in families. The gene change is a chance, rare occurrence. ...Read more

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What is the cause of progeria?

What is the cause of progeria?

Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. ...Read more

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What is progeria and how is it treated?

What is progeria and how is it treated?

Supportive care: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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What is the cause, symptoms, treatment of progeria?

What is the cause, symptoms, treatment of progeria?

Supportive care: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks ; provide guidence for your local source of care. They can also help you find support groups ; other parents in the same situation. ...Read more

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It happens that a cure for progeria syndrome lead to the "fountain of youth"?

Neither are likely: Given that progeria is so rare & hard to study, the likelihood of some treatment to reverse the metabolic consequence of this disease is remote. If it were, it would simply bring the kid up to the longevity of normal humans. ...Read more

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What is the genetic disorder progeria caused by? Is it a simple recessive trait?

What is the genetic disorder progeria caused by? Is it a simple recessive trait?

Two likely forms: Progeria syndrome is considered a sporadic (new mutation) phenomenon that has few prenatal indicators. At an average birth wt of 6lb (2.7kg), the relatively small size during gestation is not specific to this disorder. There are rare instances of siblings to normal parents, showing that an autosomal recessive form exists. Most begin to show signs by 6-18mo. ...Read more

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What is progeria?

What is progeria?

Supportive care: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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Is there backwards progeria?

No: I think it would be great if we could reverse the clock to some degree, but unfortunately, brad pitt's benjamin button, is only fiction. ...Read more

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What is the cause of progeria?

Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. ...Read more

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What are the tests for progeria?

See below: The gene responsible for progeria has been identified (lamin a) in april 2003. A blood test can now be performed progeria is due to a point mutation in this gene. It is not usually passed down in families. The gene change is a chance, rare occurrence. ...Read more

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How can progeria be transmitted?

Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. ...Read more

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Waht is the prognosis of progeria?

Progeria: A genetic disease which leads to premature cell death, progeria has no known cure. The average life expectancy is around the early teens though a few patients have survived into their twenties. ...Read more

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What is progeria? Can it be cured?

What is progeria? Can it be cured?

Most new mutations: Progeria is a self limited geneticnprocess with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. There is no known cure. ...Read more

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What are the symptoms of progeria?

Resources: Please check with the geneticist involved in your child's care. Also, the following website may be useful http://www. Progeriaresearch. Org/progeria_101.Html. ...Read more

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What is progeria and what causes it?

What is progeria and what causes it?

Supportive care: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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How many cases of progeria are there?

100: Over the century (1886-7) since identified. Incidence is 1 in 4 million/some report up to 8 million. ...Read more

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What is the disease progeria caused by?

What is the disease progeria caused by?

Excellent website...: For an excellent website on progeria, visit the progeria research foundation at:
http://www. Progeriaresearch. Org/progeria_101.Html. ...Read more

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What is progeria? How do people get it?

What is progeria? How do people get it?

Aging defect: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks ; provide guidence for your local source of care. They can also help you find support groups ; other parents in the same situation. ...Read more

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What is progeria and how is it treated?

Supportive care: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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What is progeria? How do people get it?

What is progeria? How do people get it?

Aging defect: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks ; provide guidence for your local source of care. They can also help you find support groups ; other parents in the same situation. ...Read more

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What disease is the opposite of progeria?

What disease is the opposite of progeria?

None yet: There are at least three people who showed slower aging than normal. One, Brooke, was evaluated and her DNA examined. The genes responsible for Progeria were unaffected in her and the cause of her poor growth was never found, Another, now over 40 years old and depicted here, is physically like a ten year old but has no language and so far has had no etiology found for his growth ...Read more

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How long can children with progeria live?

Record is 27y: The accelerated aging syndrome known as progeria truly accelerates the patients aging and illness profile. Most succumb to complications of coronary heart disease as early as their teens. ...Read more

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What are the chances of getting progeria?

What are the chances of getting progeria?

1 in 4 million: For parents who have never has a child with progeria. It is a "sporadic autosomal dominant" mutation-sporadic because it is a new change in that family-dominant since only 1 copy of the gene needs to be change in order to have the syndrome. ...Read more

Dr. Jay Park Dr. Park
2 doctors agreed:
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How rare is progeria in the world right now?

Dr. Jay Park Dr. Park
2 doctors agreed:
How rare is progeria in the world right now?

See below: The incidence of progeria is approximately 1 in 8 million. ...Read more

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I want to know my options for treating progeria?

Become informed: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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What can be done to help children with progeria?

What can be done to help children with progeria?

Supportive care: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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Please advise what is the importance to progeria?

Please advise what is the importance to progeria?

Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. It helps many of us appreciate the miracle of life when we see how many normal kids avoid such outcomes. ...Read more

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What is the record age for a person with progeria?

I found one @ 27y: The progeria syndrome is marked by early onset of ageing & noted in the written literature as far back as 1886. The life expectancy quoted in a study of 13 patients ranged from 7-27y with average of14.2 y.For a recent review of information go to:
www. Ncbi. Nlm. Nih. Gov/pmc/articles/pmc2940940/? Tool=pmcentrez. ...Read more

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How does Progeria affect the individual who has it?

How does Progeria affect the individual who has it?

Ageing quickly: The progeria syndrome is marked by early onset of ageing & noted in the written literature as far back as 1886. The life expectancy quoted in a study of 13 patients ranged from 7-27y with average of 14.2 y.Coronary artery disease and other features of ageing are the main morbidity. For a recent review of information go to:
www. Ncbi. Nlm. Nih. Gov/pmc/articles/pmc2940940/? Tool=pmcentrez. ...Read more

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What is the definition or description of: Progeria?

What is the definition or description of: Progeria?

A rare condition: Progeria is a rare hereditary condition affecting the blood vessels, skin and musculoskeletal system that creates the impression of accelerated aging. Some aging processes are truly accelerated such as atherosclerosis of the coronary and carotid arteries, resulting early death. Most of the other illnesses of aging such as cancer, cataracts, and dementia do not occur but deposition of a substance associated with aging, liposuction, in vital organs leads to impairment of the liver, heart, adrenal glands, brain and skeletal system. Another protein, progeria, leads to defective DNA expression and repair. This protein also enhances the development of atherosclerosis. Children with Progeria have brittle bones, pathological fractures, feeding problems, dental abnormalities, hearing loss, growth failure, hairless, and clotting problems. Characteristic facial features are described. ...Read more

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Can the symptoms of progeria be treated or reversed?

Can the symptoms of progeria be treated or reversed?

No: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They seldom live past their teens & often die of advanced heart disease. ...Read more

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Could you give me some information on the disease progeria?

Could you give me some information on the disease progeria?

Progeria: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. The oldest on record died at 27. Death is often due to advanced heart disease. ...Read more

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Could you explain what is progeria and how do people get it?

Could you explain what is progeria and how do people get it?

Supportive care: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks ; provide guidence for your local source of care. They can also help you find support groups ; other parents in the same situation. ...Read more

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Is there such a thing as backwards progeria like in that movie?

Not that I know.: Interesting movie with brad pitt-but purely fiction! ...Read more

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Is progeria curable?

Is progeria curable?

No: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They seldom live past their teens & often die of advanced heart disease. ...Read more

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How is progeria caused in the chromosomes?

New mutation of gene: There is no particular pattern like autosomal dominant, recessive or x-linked. It is new mutation go genes ...Read more