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Doctor insights on: Problems Freezing Embryos Ivf

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What causes frozen embryo thawing failure?

What causes frozen embryo thawing failure?

Why do: Embryos not thaw successfully? Traditionally many sub-standard embryos have been frozen that probably should not have; these often die in thawing. The usual cause of embryo death in the past with traditional slow-freeze techniques is formation and shattering of ice crystals within the embryo. ...Read more

Dr. Mark Pack
3 doctors shared insights

Ivf (Definition)

In vitro fertilization is an assisted reproductive technology. Ivf is a procedure used to treat fertility problems and assist with the conception of a child. During ivf mature eggs are retrieved from the ovaries and fertilized by sperm in a lab. A few days later, the fertilized egg (embryo) or eggs are implanted into the uterus. One cycle of in vitro fertilization ...Read more


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How are embryos eggs monitored in the IVF treatment?

How are embryos eggs monitored in the IVF treatment?

In an embryology lab: The eggs go from the body directly into the IVF lab. Today, the lab is specially designed for air handling, lighting and temperature to support embryo growth. The embryos are cultured for 3-6 days before transfer into the uterus. Embryos receive a score for implantation potential. Sometimes checked for the number of chromosomes and even time-lapse photography. # transferred based on age&quality ...Read more

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40yrs.Old, pcos, 1st IVF cycle w/genetic testing. Four day 5 embryos - all chromosomally abnormal. Worth another try? 39 eggs were retrieved, 19 fert.

40yrs.Old, pcos, 1st IVF cycle w/genetic testing. Four day 5 embryos - all chromosomally abnormal. Worth another try? 39 eggs were retrieved, 19 fert.

Talk to the prenatal: Genetic counselor at the fertility clinic. Age-related odds are greater than 50% that each of your embryos has aneuploidy, an abnormal number of chromosomes, many of which either won't implant or wion't be carried to term. Age-related risk of having a child with autistic spectrum disorder is also high. Discuss options with your tac doctor to make an informed decision. It's a personal choice. ...Read more

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Ivf day 4 embryo transfer success rate?

Ivf  day 4 embryo transfer success rate?

Huge NumberVariables: including: age, person receiving, donors, those helping & their methods, food, emotional issues & the list goes on & on. All meaningful medical rates are after the fact data; not reliable future predictions. Why? The issues are far too complex & beyond everyone's reasonable understanding. Suggest studying: http://goo.gl/ubDC9h & http://goo.gl/FSjqDn for important issues not commonly covered. ...Read more

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IVF egg removal. 32 follicles only 7 eggs retrieved. Did Lupron (leuprolide) trigger and Hcg. Why so few?

IVF egg removal. 32 follicles only 7 eggs retrieved. Did Lupron (leuprolide) trigger and Hcg. Why so few?

Ask your doc: Many possibilities: incorrect timing (too early OR too late) or administration of hCG, bad batch of hCG, surgeon had difficulty with TVA, maybe only 7 mature follicles and the others were mid-to-small...your doctor and your embryology team are only ones who can answer what happened. Good luck with the 7, sounds good! ...Read more

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Are pgd and ivf(in vitro fertilization) the same thing?

Are pgd and ivf(in vitro fertilization) the same thing?

No but related : Ivf refers to the procedures we use the remove the eggs from your body, fertilize them in a laboratory and transfer them back into the uterus. Pgd refers to testing those embryos for genetic abnormalities before we return them back to your womb. Most ivf is done without pgd but pgd cannot be done without ivf. ...Read more

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3 failed ivf. Blocked tube. Reports ok. Age factor so donor egg. Et cancelled - poor lining. Suggested cryocautery before FET in same cycle?Is it ok?

Cervical cryo?: In the same cycle as an fet? That would not be acceptable in the United States is all i can say. Or are you asking about another form of cryo? ...Read more

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For IVF, what benefits are there for freezing embryos, vs just freezing eggs? Is freezing embryos the recommended action vs eggs?

Yes: Freezing embryos is more reliable than freezing eggs. Eggs are more likely to be damaged in the freezing process, however, improvements in freezing techniques have improved egg survival and function after thaw. Despite advancements, embryo freezing remains superior to egg freezing. ...Read more

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Will art or IVF (in vitro fertilization) cause any birth defects in the baby?

Will art or IVF (in vitro fertilization) cause any birth defects in the baby?

Not likely.: See recent impactful publcation in the new england journal of medicine [n engl j med. 2012 may 10;366(19):1803-13. Epub 2012 may 5]. The increased risk of birth defects associated with ivf was no longer significant after adjustment for parental factors. The risk of birth defects associated with icsi remained increased after multivariate adjustment. ...Read more

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Why embryo positive, uterus is normal, but still fail implants with frozen donor egg 3dft?

Why embryo positive, uterus is normal, but still fail implants with frozen donor egg 3dft?

Conception: Most likely your hormones are not at the level. Required for implantation in the uterine wall. ...Read more

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What hormones are used during IVF (in-vitro fertilization)?

IVF: An unusual question at your age. Surely if you are seeing an obstetrician for IVF, that doctor would be explaining that to you? If you are asking on behalf of someone else, she too must discuss this with her obstetrician. There should be little, if anything, to be concerned about. ...Read more

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Frozen sperm. Fresh eggs. Both proven donors. Nulligravid 42 yo woman. Odds of conception after et with 3?

Frozen sperm. Fresh eggs. Both proven donors. Nulligravid 42 yo woman. Odds of conception after et with 3?

Very good: The odds are excellent as long as all other aspects of your workup have been negative. Pregnancy rate with 2 embryos can give a 70% chance. Replacing 3 embryos in this situation would not be suggested as long as the egg donor was 21-28. Most donors are not accepted over 30. The risk of triplets is quite high and would cause significant obstetrical issues such as prematurity, decreased fetal size.. ...Read more

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Having endometriosis stage 4 went trough IVF fresh nd frozen..Still 11 embryos are freezed..Should i continue to IVF or get laparoscopic treatment?

Couple Options: If you have a hydrosalpinx on the fallopian tube it might be a good idea to remove the fallopian tube(s) affected. It may be worthwhile to do pgd on the embryos to see if they are genetically normal. Despite your age likely many if not most of the embryos are not genetically normal given the situation so that may prevent you from transferring embryos that will not lead to pregnancy. ...Read more

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Can one give donor egg as infertility treatment?

Can one give donor egg as infertility treatment?

Probably: Donor eggs are used to treat severe female infertility caused by poor egg quality. Female age is the most common cause of poor eggs. Donor eggs are also useful for women after cancer chemo and some genetic causes. I am not sure i completely understood your question but hope this helps. Donor egg ivf is extremely successful with success rates as high as 60-80% on first try. ...Read more

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How many artificial inseminations (IUI) are usually recommended before trying in vitro fertilization?

How many artificial inseminations (IUI) are usually recommended before trying in vitro fertilization?

It varies: But it’s often around 3 cycles. It can be more or fewer depending on how the IUI cycles have gone, patient age, doctor or patient agenda. ...Read more

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Can fibroids cause implantation failures during IVF procedures?

Yes: Fibroids that protrude into the uterine cavity and distorts the shape (submucous fibroid) can interfere with implantation and cause early miscarriage. ...Read more

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Doctor says two eggs they retrieved failed to fertilize by ICSI due to bad egg quality all hormone reports Ok including AMH(2.99pg/ml). isit possible?

Doctor says two eggs they retrieved failed to fertilize by ICSI due to bad egg quality  all hormone reports Ok including AMH(2.99pg/ml). isit possible?

Several reasons: There are several reasons fertilization fails. Could be egg, sperm or laboratory environment. Unfortunately, many times its hard to pin point the problem given the normal findings in the evaluation. Talk to your doctor to see what they think and how to avoid this outcome in the future. Good luck. ...Read more

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When is IVF or in vitro fertilization treatment recommended ?

When is IVF or in vitro fertilization treatment recommended ?

Infertility: Ivf today has 75% success rates and can be offered anyone who wants a pregnancy and baby even a single woman or surrogate woman for a male customer. Usually for a heterosexual couple who have tried for over a year and can find no reason for not conceiving or who have found an incorrect able problem will be able to conceive with ivf. ...Read more

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For IVF, what benefits are there for freezing embryos, vs just freezing eggs? Is freezing embryos the recommended action vs eggs?

Yes: Freezing embryos is more reliable than freezing eggs. Eggs are more likely to be damaged in the freezing process, however, improvements in freezing techniques have improved egg survival and function after thaw. Despite advancements, embryo freezing remains superior to egg freezing. ...Read more

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I am 39 and like to share my frozen embryos in return for ivf?

Probably not: You could always donate your embryos to another couple anonymously or it can even be a known situation. But, honestly, most couples needing donor embryos will choose younger embryos and it would not be in their best interest to pay for half your ivf to get 39+ year old embryos. ...Read more

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I have abortion IVF .I have 2 frozen embryos left.If abortion was couse by chromozal abnormaliti does that mean that 2 embryo left has same abnormali?

I have abortion IVF .I have 2 frozen embryos left.If abortion was couse by chromozal abnormaliti does that mean that 2 embryo left has same abnormali?

Not necessarily : Every person's situation is different so you should sit down and discuss details with your doctor, but from what you are telling me you should have an overall good chance for success. It is very possible that one of your frozen embryos could have normal chromosomes. If not, you still should have a reasonable chance for success with another cycle. Best of luck to you! ...Read more

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I hv a girl from ivf. Nw want a boy,from the 6 frozen embryos tht i had only 3 were normal and they all were girl. Can u manually attach x wid y 4 boy?

I hv a girl from ivf. Nw want a boy,from the 6 frozen embryos tht i had only 3 were normal and they all were girl. Can u manually attach x wid y 4 boy?

No: Depends on the sperm which fertilizes the egg. PIGD is the technique used to know the gender and other facts before implantation, ask your fertility doctors ...Read more

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I had my IVF on 31 October 2014 embryo transfer with frozen egg and test on. 11-11 -2014 and the test came negative what could happen?

Talk to your RE: You need to talk to your Reproductive Endocrinologist. It might be a little early, so they might want to recheck in a couple of days. ...Read more

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Hw can asprine affect growth of embryo. I have to take one 100 mg every morning for my memory problem. Should i stop taking it while going for ivf?

Hw can asprine affect growth of embryo. I have to take one 100 mg every morning for my memory problem. Should i stop taking it while going for ivf?

Low-dose aspirin is : used by some to slow memory loss in women > 65, but not reversal of memory loss in any age. It is a Class D drug in pregnancy, per the US Federal Drug Administration, as it has known adverse risks in pregnancy. Stop it now unless your Fertility Specialist okays it. Start daily folate (folic acid) supplement at least 3 mos. before conception; have a flu shot at least 2 mos. before conception. ...Read more

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Hi, 2 frozen embryos afyer ivf. Is frozen transfer better then fresh? Bmi is 29 does this go against me. Is there anything can do 2 better chances.

Hi, 2 frozen embryos afyer ivf. Is frozen transfer better then fresh? Bmi is 29 does this go against me. Is there anything can do 2 better chances.

Possibly: There are studied top suggest higher pregnancy rates from fet rather than fresh ivf, comparing of course similar quality embryos. This stems from lower hormone levels during fet cycles. You bmi should not have any significant impact. ...Read more

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I have 11mm endometrium & FET is after 7days.It will grow further.What is the maximum endometrium thickness for frozen embryo transfer in IVF ?

Perfect lining: I assume you will start Progesterone replacement soon as part of your protocol before your fet. Once Progesterone begins you will not see much growth (and possibly some thining) of the endometrial lining. Ideally you want the lining above 8 mm and triple line in appearance before start of the progesterone. There is no hard data on maximum thickness but some feel its around 18 mm. ...Read more

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Trnasfrd 2 embryos grd 1 ,8 cell.endimitrium excellent.no health problem except mild anemia(hemglbn10.5).ivf failed.can anemia cause it or othr reasn?

Trnasfrd 2 embryos grd 1 ,8 cell.endimitrium  excellent.no health problem except mild anemia(hemglbn10.5).ivf failed.can anemia cause it or othr reasn?

Not likely: I'm sorry the transfer was not successful. Mild anemia is not likely the reason the transfer failed. Unfortunately infertility issues are stressful, and transfers are often unsuccessful for no obvious reason. Talk with your doctor to see what your next options might be. ...Read more

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I m 41yrs, this is my 5th IVF with doner eggs & 4 frozen embryos transfer after 14 days test my hCG level is 598.95. what i should expect?

Fertility Specialist: Please discuss your specific concerns with more details with a qualified fertility specialist. It's a very personal and private situation. I would not share such confidential info in this forum. You are not statistics. Please understand my meaning. ...Read more

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35 yr old, stage 4 endometriosis, 2nd ivf cycle, 1BB embryo frozen. embryo transfer will occur within 2 weeks, what diet do i eat to improve chances?

35 yr old, stage 4 endometriosis, 2nd ivf cycle, 1BB embryo frozen. embryo transfer will occur within 2 weeks, what diet do i eat to improve chances?

Pregnancy diet: Once there is preparation towards conception and embryo transfer, a balanced diet with all the basic minerals and vitamins are necessary.
In your case, a balanced diet with daily dose of prenatal vitamins will be of great importance for you.
Good luck with embryo transfer. ...Read more

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I finish my herceptin (trastuzumab) treatment in 20th november 2012 and will have IVF to have my frozen embryos replaced. When would be the earliest I can do this?

I finish my herceptin (trastuzumab) treatment in 20th november 2012 and will have IVF to have my frozen embryos replaced. When would be the earliest I can do this?

Depends: The timing of pregnancy after cancer treatment varies considerably. Please discuss this with your oncologist. In most cases you will need a period of time, sometimes years without cancer before proceeding with pregnancy. In some cases it may be safer to avoid pregnancy and use a gestational surrogate. Again, these are issues that you should discuss with your oncologist. ...Read more

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Is there anything i can do to inprove my chances for a frozen embryo transfer? 2 failed fresh IVF and icsi but did get pregnant on icsi 2-3 weeks

Is there anything i can do to inprove my chances for a frozen embryo transfer? 2 failed fresh IVF and icsi but did get pregnant on icsi 2-3 weeks

Yes: Ask the clinic how successful they are at thawing embryos. Different clinics have different success rates. If you are still not getting pregnant we suggest dna damage testing on the husband's sperm. ...Read more

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What is the usual reason a frozen embryo transplant through IVF doesn't implant ?

What is the usual reason a frozen embryo transplant through IVF doesn't implant
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Don't know: Many speculative reasons can be given that are very complicated. But in actuality the true reason that implantation fails is the "black box" question that still alludes us. ...Read more

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I'm 29, have pcos and am planning on doing IVF with my own frozen eggs. What would my success chances be? How many eggs should I thaw for 5-7 embryos?

Depends: The standard therapy is the freezing of embryos (fertilized eggs). Usually 40% of retrieved eggs result in good embryos. Egg freezing is still experimental and thus you would have to expect that the embryo yield is lower than with standard ivf. If your clinic has experience with egg freezing, then ask what their success is to create embryos and most importantly, a live birth from frozen eggs. ...Read more

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I have endometriosis w/ 1 failed IVF and 3 frozen embryos left. Would another laparoscopy to remove endo help implantation with an fet? Last lap 2/13

Not likely: I think for years we were more concerned about things like that. Now we known in the absence of specific problems with the uterus lining or cavity, that most ivf cycles fail because the embryos were genetically abnormal. So at age 31 likely half of all good day 5 embryos are genetically abnormal. Hopefully on of the frozen ones is good quality and genetically normal! ...Read more

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I hadbreast cancer, thinking removing my ovaries-cancer was hormone responsive.B4 chemo had ivf&embryos frozen.Can i still carry baby without ovaries?

Yes: It would be a frozen embryo transfer. You would require a limited amounts of hormones prior to pregnancy but as long as your uterus is present that is fine. But i would speak to your fertility specialist about your frozen embryos before proceeding. ...Read more

Freezing (Definition)

Freezing is to mean turning liquid into solid form by lowering the temperature. Water begins to freeze at 32 degree f or 0 degree celsius. Freezing reduces the movement of the substance/object--solid. Also commonly used in daily communication--police says to a perpetraitor "freeze" and hopefully the bad boy/girl stays solid/still (just for fun :-)). Have ...Read more


Embryo (Definition)

An embryo is a developing human being from between 1- ...Read more