Doctor insights on:
Pro Ana Laxatives
What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more
An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more
Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?
Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more
Please can someone explain these ANA results - ANA positive (centromere 0.2) an ENA revealed positive ssa and ssa60 (4.5) I am grateful for any advice?
Sjogrens Syndrome: Anti centromere antibody is associated with limited scleroderma. A positive ANA and ss-a, ss-b antibodies are associated with sjogrens syndrome. These tests are not diagnostic by themselves and have to be evaluated along with your symptoms and physical examination to get a definite diagnosis. ...Read more
If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)
? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more
ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?
Yes: 1:320 along with positive ssDNA Ab and the symptoms you are having makes Systemic Lupus a strong possibility. I suggest seeing a Rheumatologist so they can also evaluate and potentially initiate treatments. ...Read more
What would diagnosis be with test results 1:160
C4 Complement- 13 mg
Anti-DS-DNA - 3 IU
SM antib- 7 Index
Part of the picture: those lab results should be put in perspective, what are the symptoms and signs present, the best to judge / give a diagnosis is the doctor who ordered the blood tests, all these results can just be insignificant in absence of other criteria, best wishes ...Read more
Normal C-RP, Sed Rate, CBC, CMP, Rheumatoid fac., C3/C4 Complement and Cyclic Citrul peptide. ANA was negative. Does this rule out any auto-immune?
Not necessarily: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, Lab test do not equate to disease or the lack of it. It is good that all the test results are negative. It reduces your risk of an auto-immune disease to very very low, but does not exclude it 100%. ...Read more
Lab results as follows: ANA w/titre and pattern 1:320 and thyroid peroxidase ab 484.0....Are the two related? Would hashimoto's cause high ANA level?
19month old, lab work Celicax AB profile, HX of diarrhea, all negative but t-Transglutaminase (tTG) IgG. 7 weak positive, what does this mean?
Not clear: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, form the incomplete information you provided, the child is not likely to have Celiac disease but may need follow up testing. ...Read more
What do you think?
Ana-positive, titer >1:640, speckled/ana titer 2-1:32, ANA pattern 2-homogeneous
c3 180.8, rnpab, IgG 1.5, CRP 1.9.
Possible MCTD: The highly positive ANA in a speckled pattern suggests mixed connective tissue disease. Mctd is a close cousin of lupus but usually has a better prognosis. The anti-rnp is usually be elevated in mctd. Interpreting the results of autoantibody studies can confusing. You should discuss these findings with a rheumatologist. ...Read more
Spouse has IBS & UC. Doc ordered Prometheus panel. Expensive. Worth it?Lialda & Canasa current Meds
Yes: Another cause of similar symptoms to to irritable bowel and ulcerative colitis can be celiac disease or gluten sensitivity. The test is very accurate to rule gluten sensitivity in or out. It would be nice to know that since gluten intolerance is very treatable by dietary avoidance of gluten. ...Read more
Autoimmune pancreatitis how dx? random lipase spikes & do not drink/do drugs. positive ANA - igG1 is low -facial bx chronic swelling -vit d defcnt
Biopsy Needed: Autoimmune pancreatitis is a rare type of chronic pancreatitis. On CAT scan, it sometimes looks like a pancreatic mass. I saw a patient who was thought to have pancreatic cancer. but her biopsy showed autoimmune pancreatitis. Sometimes autoimmune pancreatitis is part of IGG4-related systemic disease, and can mimic other diseases like sjogrens. Since you also have facial swelling, consider this dx ...Read more
Chronic joint pain swelling. Ra factor 11.9, sed rate 7, ANA positive and high 1:160, ccp antibodies high 250, CRP 0.4, any ideas drs? Thanks.
Son 10 chronic constipation miralax (polyethylene glycol) 5+ years Dr's always say take miralax (polyethylene glycol) need more answers what causes chronic constipation since toddler ?
Needs consultation: You need to consult with a developmental pediatrician and/or pediatric gastroenterologist.Chronic stool retention/constipation is a difficult problem to manage and most often fails when the program is inconsistent. There are long term changes in your kids bowel which should respond to a disciplined treatment plan but may take a year or more to be effective. Find the best help available. ...Read moreSee 1 more doctor answer
30yrs 5'3" 180lbs, 1 child. Main issues, Weight/ Fatigue/ Heart Palp./LowTemp/Eyebrowloss/Cold TSH 3.59,FT4 .9, TPO 1, ANA ifa, POS 1:320titer?
Is chronic constipation (daily miralax, (polyethylene glycol) frequent senna, glyc. Supp's aren't enough. Enemas needed often) in
toddlers considered a Motility issue?
Stool retention: This is more an accident than a motility issue. When/if the kid decides one day not to poop, and the next day has a hard painful stool, they may try to stop having them. Over time stool retention causes physical changes in the large bowel causing poor emptying. Parents try short treatments that fail & the problem continues. This often requires a developmental ped or pedi GI working for a year . ...Read moreSee 1 more doctor answer
Severe constipation, use laxido & bisacodyl. Tests for coeliac mixed results. Awaiting endoscopy appt. Trying to concieve, will these affect chances?
Low positive ana, dual pattern speckled, centromere. Positive aca and positive histone ab igg. After c/o skin rash and moderate right hip pain.
Need to be evaluated: A low titer (concentration) ANA test is not particularly helpful to make a diagnosis. Even with a particular pattern (speckled) and anti-centromere antibodies and anti-histone antibodies. Your rash and hip pain are more important as well as inflammatory markers like an ESR and a CBC if they are normal or not. See your doctor and ask for a referral to a rheumatologist if you are concerned. ...Read more