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Doctor insights on: Prion Diseases

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Dr. Thomas Montine
76 doctors shared insights

Prion Diseases (Overview)

An infection agent consisting only of protein. They behave in very much as slow viral infections do clinically. Many are neurodegenerative; think mad cow disease, scapie, there are others.


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Describe prion diseases?

Describe prion diseases?

Rare diseases: Prion diseases are rare disorders that the effected and transmitted by misfolded proteins. Read the site below for more information. http://ghr.nlm.nih.gov/condition/prion-disease. ...Read more

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Dr. Thomas Montine
76 doctors shared insights

Prion Diseases (Overview)

An infection agent consisting only of protein. They behave in very much as slow viral infections do clinically. Many are neurodegenerative; think mad cow disease, scapie, there are others.


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What are the symptoms of a prion disease?

What are the symptoms of a prion disease?

Neuro: Decline in mental function, rapid over a few months. The hallmark symptom, often present, is myoclonic jerks while fully conscious. Lack of coordination is common if the cerebellum is involved. ...Read more

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Managing Peripheral Vascular Disease (Checklist)

Try to continue walking
Once
Make sure risk factors are addressed (blood pressure, cholesterol)
Once
Inspect your feet daily -- call your MD with any wounds
Daily
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Could organ and blood donation cause prion disease?

Could organ and blood donation cause prion disease?

Not for donor: A donor of an organ or blood cannot be infected with a prion disease. An organ recipient can become infected with a prion disease if the donor suffered from that disease. For example, until this was recognized and screening initiatted, it was possible to transmit creutzfeld-jacob disease through cornea transplant. ...Read more

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Why do prion diseases have such long incubation periods? Can they be stopped at all?

Why do prion diseases have such long incubation periods?  Can they be stopped at all?

Supportive care only: The duration of incubation of prions is probably related to the folding state of the inoculum and the sequence of the host prion protein. At present, there is no effective treatment for prion diseases, and all are universally fatal. ...Read more

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Living with Lyme Disease (Checklist)

Consult an infectious disease doctor.
once
Treat symptoms
once
See a specialist to treat the area where the symptoms are worst
once
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Can you get a prion diseases from gm food?

Can you get a prion diseases from gm food?

No: There is no evidence--nor reason to think--that gm food should or could generate or increase infectious prions. Without comment on whether gm foods are a boon or a bane, the only way i could imagine this happening would be if some evil scientists deliberately created a gm food to generate bad prions in order to eliminate their own financial base ;). ...Read more

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How can prion diseases be prevented?

Not much: There's not much we can do at present as some forms of prion diseases have to do with genetic mutations. Prion diseases can be transmitted by exposure to prion-contaminated tissues during a medical procedure. Another type of prion disease in humans, vcjd, is acquired by eating beef products obtained from cattle with prion disease. So stay away from beef from places with endemic prion disease. ...Read more

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Living with Polycystic Kidney Disease (Checklist)

Reduce stress in your life: Stress causes cysts to grow faster
daily
Adequate daily fluid intake is a requirement for all patients with PKD
daily
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How do I know if I am at risk for prion disease? Pet scan?

How do I know if I am at risk for prion disease? Pet scan?

Why r u concerned?: No one eats human brains anymore, so human "prion disease" = cjd. There are 3 types: sporadic, familial & variant. Sporadic is impossible to predict. Familial runs in families; it's genetic and can be tested for but genotype does not predict phenotype. Variant is contracted by eating contaminated beef. Check out www.Cjdsurveillance.Com. My advice: find something else to worry about. ...Read more

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Describe prion diseases?

Rare diseases: Prion diseases are rare disorders that the effected and transmitted by misfolded proteins. Read the site below for more information. http://ghr.nlm.nih.gov/condition/prion-disease. ...Read more

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Coping with Disease Outbreaks (Checklist)

Wash hands
6x day
Cover nose and mouth
daily
Avoid unnecessary contact
daily
Alert providers of contagion
daily
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How common are prion diseases?

Not very: Hi, the most common prion disease is CJD, with a uniform incidence of approximately 1 case per million population both in the United States and internationally. Familial forms of prion diseases, such as GSS and fatal familial insomnia (FFI), are much more rare. About 10% of cases of CJD are familial, with an autosomal dominant pattern of inheritance linked to mutations in the PRNP gene. ...Read more

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What is the definition or description of: Prion diseases?

Prion: An infection agent consisting only of protein. They behave in very much as slow viral infections do clinically. Many are neurodegenerative; think mad cow disease, scapie, there are others. ...Read more

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Living with Coronary Artery Disease (Checklist)

Take meds as prescribed
Once
Exercise daily as recommended by your doctor or trainer
daily
Limit meat, dairy, and fats as much as possible
Once
Eat whole grains only - not white bread
Once
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Can you get a prion diseases from gm food?

No: There is no evidence--nor reason to think--that gm food should or could generate or increase infectious prions. Without comment on whether gm foods are a boon or a bane, the only way i could imagine this happening would be if some evil scientists deliberately created a gm food to generate bad prions in order to eliminate their own financial base ;). ...Read more

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Are the prion diseases going to ever cause a pandemic?

Are the prion diseases going to ever cause a pandemic?

Never say never: Not something i would lose sleep over as a citizen; something i would pay a lot of attention to as as beef inspector. So far, safeguards seem solid. Yet, 1/3 of the wild elk population in the us west is "infected" with prion disease, without illness. Is this a problem, or normal nature? Prudence says pay attention, but don't panic. ...Read more

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Living with Addison's Disease (Checklist)

Wear a medic alert
Once
Take additional hydrocortisone/prednisone for fever or injury
Once
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Can you get prion diseases by eating anything other than brains?

Can you get prion diseases by eating anything other than brains?

Yes: Infectious types of prions have even been found in muscle tissue. But it's not that they could concentrate there adequately to cause infection. The entire biosphere has a substratum of prions with which all biological systems are in equilibrium. For infection to occur, this equilibrium must be tipped adversely which is hard to do. Feeding prion infected beef back to cattle can do, or cannibalism. ...Read more

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How can prion diseases be prevented?

Not much: There's not much we can do at present as some forms of prion diseases have to do with genetic mutations. Prion diseases can be transmitted by exposure to prion-contaminated tissues during a medical procedure. Another type of prion disease in humans, vcjd, is acquired by eating beef products obtained from cattle with prion disease. So stay away from beef from places with endemic prion disease. ...Read more

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