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Doctor insights on: Primidone

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Dr. Andrew Seibert
14 doctors shared insights

Primidone (Overview)

Primidone is a seizure agent which is a kind of brain and nerve drug.


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Pat. With essential tremor not response to propranolol and primidone .What is next management?

Pat. With essential tremor not response to propranolol and primidone .What is next management?

Many: Propranolol can be incr to as much as 320 mg a day if hr and BP permit. Primidone can be increased to as much as 750 mg/day, limited initially by n, v, and ataxia (incoordination). Other drugs are: gabapentin, alprazolam, topiramate and finally, deep brain stimulation. Tremor that does not cause impairment or embarrassment does not require treatment. ...Read more

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Dr. Andrew Seibert
14 doctors shared insights

Primidone (Overview)

Primidone is a seizure agent which is a kind of brain and nerve drug.


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Why would someone need a primidone blood measurement?

Why would someone  need a primidone blood measurement?

To prevent toxicity: Primidone has a complex metabolism and active metabolites. It is affected by failure of other organ systems so levels must be monitored. ...Read more

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Mysoline (primidone) -- how long does it take to work?

Mysoline (primidone) -- how long does it take to work?

15 minutes plus: Mysoline (primidone) is only available for oral use. Therefore it will take at least 15 minutes before a useful blood level can be reached. It can take much much longer depending on factors such as person's age, general health, weight, fever, type of condition treated, etc. ...Read more

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Can primidone 100mg/day cause cognitive deficits?

Can primidone 100mg/day cause cognitive deficits?

Maybe: Primidone does have sedative properties which can cause cognitive deficits but not permanently. However, i cannot speak for the original condition the drug has been prescribed which may cause cognitive deficits. ...Read more

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Why would someone need a primidone blood measurement?

To prevent toxicity: Primidone has a complex metabolism and active metabolites. It is affected by failure of other organ systems so levels must be monitored. ...Read more

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Can I take primidone while breastfeeding?

Can I take primidone while breastfeeding?

Yes: Caution should be taken if breastfeeding while on this med. Both primadone and a metabolite Phenobarbital will pass to baby and can produce sedation in the neonatal period. Relative transfer <9% of mothers dose, with serum levels from trace to <1/2 therapuetic for both. Harriet lane c2-caution, hale L3 moderately safe. See medications and mothers milk 14ed. Hale, 2010. ...Read more

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Taking primidone and alkaline phosphatase is going up. Do I care?

Alk Phos: While Primidone may be the culprit, bone or liver disease must be ruled out. I would recommend a fractionated alk phos (shows which isoenzyme is elevated) and then proceed accordingly -- you may benefit from a right upper quadrant ultrasound (if liver isoenzyme is elevated) or a bone scan (if bone isoenzyme is elevated). ...Read more

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Please tell me about mysoline (primidone) tabs? Is it for seizures?

Yes: Mysoline, generically known as primidone, is an anti-convulsive drug. It is also useful for treating certain types of tremor. This is an "old" drug, but still useful in the right situations. ...Read more

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My hands jerk n i don't know if it's from my medication? Please help, i take primidone 250mg n it's not working.

Get diagnosed: Your jerks might represent myoclonus, and unlikely that Primidone is culprit, as it usually suppresses tremors, and focal seizures. But in some cases, older anti-epileptic drugs, especially those metabolized to barbiturates, could worsen myoclonus. Get this phenomenon diagnosed, and revise therapy as needed. Get referred to a neurologist. ...Read more

Dr. James Dukelow
13 doctors shared insights

Mysoline (Definition)

Mysoline is a seizure agent which is a kind of ...Read more